KEGG   Homo sapiens (human): 84867
Entry
84867             CDS       T01001                                 
Symbol
PTPN5, PTPSTEP, STEP, STEP61
Name
(RefSeq) protein tyrosine phosphatase non-receptor type 5
  KO
K18018  tyrosine-protein phosphatase non-receptor type 5 [EC:3.1.3.48]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
Network
nt06526  MAPK signaling
  Element
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    84867 (PTPN5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    84867 (PTPN5)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     84867 (PTPN5)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    84867 (PTPN5)
SSDB
Motif
Pfam: Y_phosphatase DSPc Y_phosphatase3
Other DBs
NCBI-GeneID: 84867
NCBI-ProteinID: NP_008837
OMIM: 176879
HGNC: 9657
Ensembl: ENSG00000110786
UniProt: P54829 Q86TL3
Structure
Position
11:complement(18727928..18792721)
AA seq 565 aa
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPP
PPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLV
SSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPED
RRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQ
ERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLL
QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIR
GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYD
GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQ
TCEQYQFVHHVMSLYEKQLSHQSPE
NT seq 1698 nt   +upstreamnt  +downstreamnt
atgaattatgagggagccaggagtgagagagagaaccacgctgctgatgactccgaggga
ggggccctggacatgtgctgcagtgagaggctaccgggtctcccccagccgatagtgatg
gaggcactggacgaggctgaagggctccaggactcacagagagagatgccgccaccccct
cctccctcgccgccctcagatccagctcagaagccaccacctcgaggcgctgggagccac
tccctcactgtcaggagcagcctgtgcctgttcgctgcctcacagttcctgcttgcctgt
ggggtgctctggttcagcggttatggccacatctggtcacagaacgccacaaacctcgtc
tcctctttgctgacgctcctgaaacagctggaacccacggcctggcttgactctgggacg
tggggagtccccagtctgctgctggtctttctgtccgtgggcctggtcctcgttaccacc
ctggtgtggcacctcctgaggacacccccagagccacccaccccactgccccctgaggac
aggcgccagtcagtgagccgccagccctccttcacctactcagagtggatggaggagaag
atcgaggatgacttcctggacctcgacccggtgcccgagactcctgtgtttgattgtgtg
atggacatcaagcctgaggctgaccccacctcactcaccgtcaagtccatgggtctgcag
gagaggaggggttccaatgtctccctgaccctggacatgtgcactccgggctgcaacgag
gagggctttggctatctcatgtccccacgtgaggagtccgcccgcgagtacctgctcagc
gcctcccgtgtcctccaagcagaagagcttcatgaaaaggccctggaccctttcctgctg
caggcggaattctttgaaatccccatgaactttgtggatccgaaagagtacgacatccct
gggctggtgcggaagaaccggtacaaaaccatacttcccaaccctcacagcagagtgtgt
ctgacctcaccagaccctgacgaccctctgagttcctacatcaatgccaactacatccgg
ggctatggtggggaggagaaggtgtacatcgccactcagggacccatcgtcagcacggtc
gccgacttctggcgcatggtgtggcaggagcacacgcccatcattgtcatgatcaccaac
atcgaggagatgaacgagaaatgcaccgagtattggccggaggagcaggtggcgtacgac
ggtgttgagatcactgtgcagaaagtcattcacacggaggattaccggctgcgactcatc
tccctcaagagtgggactgaggagcgaggcctgaagcattactggttcacatcctggccc
gaccagaagaccccagaccgggcccccccactcctgcacctggtgcgggaggtggaggag
gcagcccagcaggaggggccccactgtgcccccatcatcgtccactgcagtgcagggatt
gggaggaccggctgcttcattgccaccagcatctgctgccagcagctgcggcaggagggt
gtggtggacatcctgaagaccacgtgccagctccgtcaggacaggggcggcatgatccag
acatgcgagcagtaccagtttgtgcaccacgtcatgagcctctacgaaaagcagctgtcc
caccagtccccagaatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (21)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (18)   
DNA sequence (42)   
   RefSeq(nuc) (18)   
   GenBank (12)   
   EMBL (12)   
3D Structure (10)   
   PDB (10)   
Protein domain (3)   
   Pfam (3)   
All databases (103)   

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