KEGG   Homo sapiens (human): 8526
Entry
8526              CDS       T01001                                 
Symbol
DGKE, AHUS7, DAGK5, DAGK6, DGK, NPHS7
Name
(RefSeq) diacylglycerol kinase epsilon
  KO
K00901  diacylglycerol kinase (ATP) [EC:2.7.1.107]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00561  Glycerolipid metabolism
hsa00564  Glycerophospholipid metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
hsa04072  Phospholipase D signaling pathway
hsa05231  Choline metabolism in cancer
Disease
H01657  Nephrotic syndrome
H01726  Membranoproliferative glomerulonephritis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    8526 (DGKE)
   00564 Glycerophospholipid metabolism
    8526 (DGKE)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    8526 (DGKE)
   04072 Phospholipase D signaling pathway
    8526 (DGKE)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    8526 (DGKE)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.107  diacylglycerol kinase (ATP)
     8526 (DGKE)
SSDB
Motif
Pfam: DAGK_acc DAGK_cat C1_1 YegS_C
Other DBs
NCBI-GeneID: 8526
NCBI-ProteinID: NP_003638
OMIM: 601440
HGNC: 2852
Ensembl: ENSG00000153933
UniProt: P52429 A1L4Q0
Position
17:56834151..56869567
AA seq 567 aa
MEAERRPAPGSPSEGLFADGHLILWTLCSVLLPVFITFWCSLQRSRRQLHRRDIFRKSKH
GWRDTDLFSQPTYCCVCAQHILQGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKNDTKVL
DAMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKNEKCDFG
EFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSGTNMGEGLLGEF
RILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEK
YIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYY
NLRKPKEFTMNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQEC
KDLNKKVELELDGERVALPSLEGIIVLNIGYWGGGCRLWEGMGDETYPLARHDDGLLEVV
GVYGSFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHA
MMLYFSGEQTDDDISSTSDQEDIKATE
NT seq 1704 nt   +upstreamnt  +downstreamnt
atggaagcggagaggcggccggcgccgggctcgccctccgagggcctgtttgcggacggg
cacctgatcttgtggacgctgtgctcggtcctgctgccggtgttcatcaccttctggtgt
agcctccagcggtcgcgccggcagctgcaccgcagggacatcttccgcaagagcaagcac
gggtggcgcgacacggacctgttcagccagcccacctactgctgcgtgtgcgcgcagcac
attctgcagggcgccttctgcgactgctgcgggctccgcgtggacgagggctgcctcagg
aaggccgacaagcgcttccagtgcaaggagattatgctcaagaatgacaccaaggtcctg
gacgccatgccccaccactggatccggggcaacgtgcccctgtgcagttactgtatggtt
tgcaagcagcagtgtggctgtcaacccaagctttgcgattacaggtgcatttggtgccag
aaaacagtacatgatgagtgcatgaaaaatagtttaaagaatgaaaaatgtgattttgga
gaattcaaaaacctaatcattccaccaagttatttaacatccattaatcagatgcgtaaa
gacaaaaaaacagattatgaagtgctagcctctaagcttggaaagcagtggaccccatta
ataatcctggccaactctcgtagtggaactaatatgggagaaggactgttgggagaattt
aggatcttgttgaatccagtccaggtttttgatgtaactaaaactcctcctatcaaagcc
ctacaactctgtactcttctcccatattattcagctcgagtacttgtttgtggaggggat
gggactgtagggtgggtcctggatgcagttgatgacatgaagattaagggacaagaaaag
tacattccacaagttgcagttttgcctctgggaacaggcaacgatctatccaatacattg
ggttggggtacaggttatgctggagaaattccagttgcgcaggttttgcgaaatgtaatg
gaagcagatggaattaaactagatcgatggaaagttcaagtaacaaataaaggatactac
aacttaagaaaacccaaggaattcacaatgaacaactatttttctgttggacctgatgct
ctcatggctctcaattttcatgctcatcgtgagaaggcaccatctctgttttctagcaga
attcttaataaggcggtttacttattctatggaaccaaagattgtttagtgcaagaatgt
aaagatttgaataaaaaagttgagctagaactggatggtgagcgagtagcactgcccagc
ttggaaggtattatagttctgaacatcggatactggggcggtggctgcagactatgggaa
gggatgggggacgagacttaccctctagccaggcatgacgatggtctgctggaagtcgtt
ggagtatatgggtctttccactgtgctcagattcaagtaaaactggctaatccttttcga
ataggacaggcacatacagtgaggctgattttgaagtgctccatgatgccaatgcaggtg
gatggggagccttgggcccaagggccctgcactgtcaccataactcacaagacacatgca
atgatgttatatttctctggagaacaaacagatgatgacatctctagtacttcggatcaa
gaagatataaaggcgactgaatag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (15)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (38)   
   RefSeq(nuc) (14)   
   GenBank (12)   
   EMBL (12)   
Protein domain (4)   
   Pfam (4)   
All databases (88)   

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