KEGG   Homo sapiens (human): 8549
Entry
8549              CDS       T01001                                 
Symbol
LGR5, FEX, GPR49, GPR67, GRP49, HG38
Name
(RefSeq) leucine rich repeat containing G protein-coupled receptor 5
  KO
K04308  leucine-rich repeat-containing G protein-coupled receptor 5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04310  Wnt signaling pathway
Network
nt06505  WNT signaling
  Element
N01440  Wnt signaling modulation, LGR/RSPO
Drug target
Petosemtamab: D12416
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    8549 (LGR5)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    8549 (LGR5)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   R-spondin
    8549 (LGR5)
SSDB
Motif
Pfam: LRR_8 LRR_4 LRR_5 LRR_1 LRR_9 7tm_1 LRRNT
Other DBs
NCBI-GeneID: 8549
NCBI-ProteinID: NP_003658
OMIM: 606667
HGNC: 4504
Ensembl: ENSG00000139292
UniProt: O75473 A0A0A8K8C7
Structure
Position
12:71439129..71586310
AA seq 907 aa
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSEL
PSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM
LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ
AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD
LNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA
FQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS
YNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFST
LPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCC
AFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQ
CSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIA
AVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAAL
ERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEP
STMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNC
PVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYV
WTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSS
VAFVPCL
NT seq 2724 nt   +upstreamnt  +downstreamnt
atggacacctcccggctcggtgtgctcctgtccttgcctgtgctgctgcagctggcgacc
gggggcagctctcccaggtctggtgtgttgctgaggggctgccccacacactgtcattgc
gagcccgacggcaggatgttgctcagggtggactgctccgacctggggctctcggagctg
ccttccaacctcagcgtcttcacctcctacctagacctcagtatgaacaacatcagtcag
ctgctcccgaatcccctgcccagtctccgcttcctggaggagttacgtcttgcgggaaac
gctctgacatacattcccaagggagcattcactggcctttacagtcttaaagttcttatg
ctgcagaataatcagctaagacacgtacccacagaagctctgcagaatttgcgaagcctt
caatccctgcgtctggatgctaaccacatcagctatgtgcccccaagctgtttcagtggc
ctgcattccctgaggcacctgtggctggatgacaatgcgttaacagaaatccccgtccag
gcttttagaagtttatcggcattgcaagccatgaccttggccctgaacaaaatacaccac
ataccagactatgcctttggaaacctctccagcttggtagttctacatctccataacaat
agaatccactccctgggaaagaaatgctttgatgggctccacagcctagagactttagat
ttaaattacaataaccttgatgaattccccactgcaattaggacactctccaaccttaaa
gaactaggatttcatagcaacaatatcaggtcgatacctgagaaagcatttgtaggcaac
ccttctcttattacaatacatttctatgacaatcccatccagtttgttgggagatctgct
tttcaacatttacctgaactaagaacactgactctgaatggtgcctcacaaataactgaa
tttcctgatttaactggaactgcaaacctggagagtctgactttaactggagcacagatc
tcatctcttcctcaaaccgtctgcaatcagttacctaatctccaagtgctagatctgtct
tacaacctattagaagatttacccagtttttcagtctgccaaaagcttcagaaaattgac
ctaagacataatgaaatctacgaaattaaagttgacactttccagcagttgcttagcctc
cgatcgctgaatttggcttggaacaaaattgctattattcaccccaatgcattttccact
ttgccatccctaataaagctggacctatcgtccaacctcctgtcgtcttttcctataact
gggttacatggtttaactcacttaaaattaacaggaaatcatgccttacagagcttgata
tcatctgaaaactttccagaactcaaggttatagaaatgccttatgcttaccagtgctgt
gcatttggagtgtgtgagaatgcctataagatttctaatcaatggaataaaggtgacaac
agcagtatggacgaccttcataagaaagatgctggaatgtttcaggctcaagatgaacgt
gaccttgaagatttcctgcttgactttgaggaagacctgaaagcccttcattcagtgcag
tgttcaccttccccaggccccttcaaaccctgtgaacacctgcttgatggctggctgatc
agaattggagtgtggaccatagcagttctggcacttacttgtaatgctttggtgacttca
acagttttcagatcccctctgtacatttcccccattaaactgttaattggggtcatcgca
gcagtgaacatgctcacgggagtctccagtgccgtgctggctggtgtggatgcgttcact
tttggcagctttgcacgacatggtgcctggtgggagaatggggttggttgccatgtcatt
ggttttttgtccatttttgcttcagaatcatctgttttcctgcttactctggcagccctg
gagcgtgggttctctgtgaaatattctgcaaaatttgaaacgaaagctccattttctagc
ctgaaagtaatcattttgctctgtgccctgctggccttgaccatggccgcagttcccctg
ctgggtggcagcaagtatggcgcctcccctctctgcctgcctttgccttttggggagccc
agcaccatgggctacatggtcgctctcatcttgctcaattccctttgcttcctcatgatg
accattgcctacaccaagctctactgcaatttggacaagggagacctggagaatatttgg
gactgctctatggtaaaacacattgccctgttgctcttcaccaactgcatcctaaactgc
cctgtggctttcttgtccttctcctctttaataaaccttacatttatcagtcctgaagta
attaagtttatccttctggtggtagtcccacttcctgcatgtctcaatccccttctctac
atcttgttcaatcctcactttaaggaggatctggtgagcctgagaaagcaaacctacgtc
tggacaagatcaaaacacccaagcttgatgtcaattaactctgatgatgtcgaaaaacag
tcctgtgactcaactcaagccttggtaacctttaccagctccagcatcacttatgacctg
cctcccagttccgtgccatcaccagcttatccagtgactgagagctgccatctttcctct
gtggcatttgtcccatgtctctaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (42)   
   RefSeq(nuc) (8)   
   GenBank (17)   
   EMBL (17)   
3D Structure (7)   
   PDB (7)   
Protein domain (7)   
   Pfam (7)   
All databases (95)   

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