KEGG   Homo sapiens (human): 8600
Entry
8600              CDS       T01001                                 
Symbol
TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, sOdf
Name
(RefSeq) TNF superfamily member 11
  KO
K05473  tumor necrosis factor ligand superfamily member 11
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04380  Osteoclast differentiation
hsa04917  Prolactin signaling pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa05207  Chemical carcinogenesis - receptor activation
hsa05224  Breast cancer
hsa05323  Rheumatoid arthritis
Network
nt06227  Nuclear receptor signaling (cancer)
nt06516  TNF signaling
  Element
N01362  Nuclear-initiated progesterone signaling pathway
N01798  TNFSF11-TNFRSF11A signaling pathway
Disease
H00436  Osteopetrosis
H01470  Giant cell tumor of bone
Drug target
Denosumab: D03684<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    8600 (TNFSF11)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    8600 (TNFSF11)
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    8600 (TNFSF11)
   04928 Parathyroid hormone synthesis, secretion and action
    8600 (TNFSF11)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    8600 (TNFSF11)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    8600 (TNFSF11)
  09162 Cancer: specific types
   05224 Breast cancer
    8600 (TNFSF11)
  09163 Immune disease
   05323 Rheumatoid arthritis
    8600 (TNFSF11)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    8600 (TNFSF11)
   04090 CD molecules [BR:hsa04090]
    8600 (TNFSF11)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Tumor necrosis fators
   8600 (TNFSF11)
CD molecules [BR:hsa04090]
 Proteins
  8600 (TNFSF11)
SSDB
Motif
Pfam: TNF DisA DUF6264 DUF6621
Other DBs
NCBI-GeneID: 8600
NCBI-ProteinID: NP_003692
OMIM: 602642
HGNC: 11926
Ensembl: ENSG00000120659
UniProt: O14788 Q5T9Y4
Structure
Position
13:42562736..42608013
AA seq 317 aa
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV
VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK
QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH
KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV
YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD
PDQDATYFGAFKVRDID
NT seq 954 nt   +upstreamnt  +downstreamnt
atgcgccgcgccagcagagactacaccaagtacctgcgtggctcggaggagatgggcggc
ggccccggagccccgcacgagggccccctgcacgccccgccgccgcctgcgccgcaccag
ccccctgccgcctcccgctccatgttcgtggccctcctggggctggggctgggccaggtt
gtctgcagcgtcgccctgttcttctatttcagagcgcagatggatcctaatagaatatca
gaagatggcactcactgcatttatagaattttgagactccatgaaaatgcagattttcaa
gacacaactctggagagtcaagatacaaaattaatacctgattcatgtaggagaattaaa
caggcctttcaaggagctgtgcaaaaggaattacaacatatcgttggatcacagcacatc
agagcagagaaagcgatggtggatggctcatggttagatctggccaagaggagcaagctt
gaagctcagccttttgctcatctcactattaatgccaccgacatcccatctggttcccat
aaagtgagtctgtcctcttggtaccatgatcggggttgggccaagatctccaacatgact
tttagcaatggaaaactaatagttaatcaggatggcttttattacctgtatgccaacatt
tgctttcgacatcatgaaacttcaggagacctagctacagagtatcttcaactaatggtg
tacgtcactaaaaccagcatcaaaatcccaagttctcataccctgatgaaaggaggaagc
accaagtattggtcagggaattctgaattccatttttattccataaacgttggtggattt
tttaagttacggtctggagaggaaatcagcatcgaggtctccaacccctccttactggat
ccggatcaggatgcaacatactttggggcttttaaagttcgagatatagattga

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