| Entry |
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| Symbol |
AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS
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| Name |
(RefSeq) aldo-keto reductase family 1 member C3
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| KO |
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| Organism |
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| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
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| Module |
| hsa_M00976 | C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone |
| hsa_M00977 | C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone |
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| Network |
nt06019 Steroid hormone biosynthesis nt06226 KEAP1-NRF2 signaling (cancer) nt06251 CYP-mediated ROS formation (cancer) |
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| Element |
| N01401 | Benzo[a]pyrenre to CYP-mediated metabolism |
| N01413 | Metals to KEAP1-NRF2 signalig pathway |
| N01541 | Testosterone biosynthesis |
| N01802 | Dihydrotestosterone biosynthesis |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
8644 (AKR1C3)
00590 Arachidonic acid metabolism
8644 (AKR1C3)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
8644 (AKR1C3)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
8644 (AKR1C3)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
8644 (AKR1C3)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
8644 (AKR1C3)
1.1.1.188 prostaglandin-F synthase
8644 (AKR1C3)
1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
8644 (AKR1C3)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
8644 (AKR1C3)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
10:5048781..5107686
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| AA seq |
323 aa
MDSKHQCLKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM
SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD
RNLHYFNSDSFASHPNYPYSDEY |
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| NT seq |
972 nt +upstreamnt +downstreamnt
atggattcaaaacatcagtgtttgaagctaaatgatggtcacttcatgcctgtcctggga
tttggcacctatgcacctccagaggttccgagaagtaaagctttggaggtcacaaaatta
gcaatagaagctgggttccgccatatagattctgctcatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtccacttttcatcgaccagagttggtccgaccagccttggaa
aactcactgaagaaagctcaattggactatgttgacctctatcttattcattctccaatg
tctctaaagccaggtgaggaactttcaccaacagatgaaaatggaaaagtaatatttgac
atagtggatctctgtaccacctgggaggccatggagaagtgtaaggatgcaggattggcc
aagtccattggggtgtcaaacttcaaccgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccgtatttcaaccggagt
aaattgctagatttctgcaagtcgaaagatattgttctggttgcctatagtgctctggga
tctcaacgagacaaacgatgggtggacccgaactccccggtgctcttggaggacccagtc
ctttgtgccttggcaaaaaagcacaagcgaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcgcatcagacagaac
gtgcaggtttttgagttccagttgactgcagaggacatgaaagccatagatggcctagac
agaaatctccactattttaacagtgatagttttgctagccaccctaattatccatattca
gatgaatattaa |
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