KEGG   Homo sapiens (human): 8654
Entry
8654              CDS       T01001                                 
Symbol
PDE5A, CGB-PDE, CN5A, PDE5
Name
(RefSeq) phosphodiesterase 5A
  KO
K13762  cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04022  cGMP-PKG signaling pathway
Drug target
Avanafil: D03217<US>
Caffeine (DG00974): D00528<JP> D01453<JP> D07603<US>
Dasantafil: D03657
Dipyridamole: D00302<JP/US>
Gisadenafil (DG01258): D09621 D09622
Sildenafil (DG00484): D02229<JP/US> D08514
Tadalafil: D02008<JP/US>
Udenafil: D10027
Vardenafil (DG00487): D02731 D03260<JP/US> D08668 D09989
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    8654 (PDE5A)
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    8654 (PDE5A)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     8654 (PDE5A)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2
Other DBs
NCBI-GeneID: 8654
NCBI-ProteinID: NP_001074
OMIM: 603310
HGNC: 8784
Ensembl: ENSG00000138735
UniProt: O76074
Structure
Position
4:complement(119494403..119628804)
AA seq 875 aa
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
NT seq 2628 nt   +upstreamnt  +downstreamnt
atggagcgggccggccccagcttcgggcagcagcgacagcagcagcagccccagcagcag
aagcagcagcagagggatcaggactcggtcgaagcatggctggacgatcactgggacttt
accttctcatactttgttagaaaagccaccagagaaatggtcaatgcatggtttgctgag
agagttcacaccatccctgtgtgcaaggaaggtatcagaggccacaccgaatcttgctct
tgtcccttgcagcagagtcctcgtgcagataacagtgcccctggaacaccaaccaggaaa
atctctgcctctgaatttgaccggcctcttagacccattgttgtcaaggattctgaggga
actgtgagcttcctctctgactcagaaaagaaggaacagatgcctctaacccctccaagg
tttgatcatgatgaaggggaccagtgctcaagactcttggaattagtgaaggatatttct
agtcatttggatgtcacagccttatgtcacaaaattttcttgcatatccatggactgata
tctgctgaccgctattccctgttccttgtctgtgaagacagctccaatgacaagtttctt
atcagccgcctctttgatgttgctgaaggttcaacactggaagaagtttcaaataactgt
atccgcttagaatggaacaaaggcattgtgggacatgtggcagcgcttggtgagcccttg
aacatcaaagatgcatatgaggatcctcggttcaatgcagaagttgaccaaattacaggc
tacaagacacaaagcattctttgtatgccaattaagaatcatagggaagaggttgttggt
gtagcccaggccatcaacaagaaatcaggaaacggtgggacatttactgaaaaagatgaa
aaggactttgctgcttatttggcattttgtggtattgttcttcataatgctcagctctat
gagacttcactgctggagaacaagagaaatcaggtgctgcttgaccttgctagtttaatt
tttgaagaacaacaatcattagaagtaattttgaagaaaatagctgccactattatctct
ttcatgcaagtgcagaaatgcaccattttcatagtggatgaagattgctccgattctttt
tctagtgtgtttcacatggagtgtgaggaattagaaaaatcatctgatacattaacaagg
gaacatgatgcaaacaaaatcaattacatgtatgctcagtatgtcaaaaatactatggaa
ccacttaatatcccagatgtcagtaaggataaaagatttccctggacaactgaaaataca
ggaaatgtaaaccagcagtgcattagaagtttgctttgtacacctataaaaaatggaaag
aagaataaagttataggggtttgccaacttgttaataagatggaggagaatactggcaag
gttaagcctttcaaccgaaatgacgaacagtttctggaagcttttgtcatcttttgtggc
ttggggatccagaacacgcagatgtatgaagcagtggagagagccatggccaagcaaatg
gtcacattggaggttctgtcgtatcatgcttcagcagcagaggaagaaacaagagagcta
cagtcgttagcggctgctgtggtgccatctgcccagacccttaaaattactgactttagc
ttcagtgactttgagctgtctgatctggaaacagcactgtgtacaattcggatgtttact
gacctcaaccttgtgcagaacttccagatgaaacatgaggttctttgcagatggatttta
agtgttaagaagaattatcggaagaatgttgcctatcataattggagacatgcctttaat
acagctcagtgcatgtttgctgctctaaaagcaggcaaaattcagaacaagctgactgac
ctggagatacttgcattgctgattgctgcactaagccacgatttggatcaccgtggtgtg
aataactcttacatacagcgaagtgaacatccacttgcccagctttactgccattcaatc
atggaacaccatcattttgaccagtgcctgatgattcttaatagtccaggcaatcagatt
ctcagtggcctctccattgaagaatataagaccacgttgaaaataatcaagcaagctatt
ttagctacagacctagcactgtacattaagaggcgaggagaattttttgaacttataaga
aaaaatcaattcaatttggaagatcctcatcaaaaggagttgtttttggcaatgctgatg
acagcttgtgatctttctgcaattacaaaaccctggcctattcaacaacggatagcagaa
cttgtagcaactgaattttttgatcaaggagacagagagagaaaagaactcaacatagaa
cccactgatctaatgaacagggagaagaaaaacaaaatcccaagtatgcaagttgggttc
atagatgccatctgcttgcaactgtatgaggccctgacccacgtgtcagaggactgtttc
cctttgctagatggctgcagaaagaacaggcagaaatggcaggcccttgcagaacagcag
gagaagatgctgattaatggggaaagcggccaggccaagcggaactga

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