KEGG   Homo sapiens (human): 873
Entry
873               CDS       T01001                                 
Symbol
CBR1, CBR, PG-9-KR, SDR21C1, hCBR1
Name
(RefSeq) carbonyl reductase 1
  KO
K00079  carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00790  Folate biosynthesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05208  Chemical carcinogenesis - reactive oxygen species
Network
nt06250  DNA adduct formation (cancer)
  Element
N01381  NNK to DNA adducts
N01382  NNK to DNA adducts
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    873 (CBR1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    873 (CBR1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    873 (CBR1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    873 (CBR1)
   05208 Chemical carcinogenesis - reactive oxygen species
    873 (CBR1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.184  carbonyl reductase (NADPH)
     873 (CBR1)
    1.1.1.189  prostaglandin-E2 9-reductase
     873 (CBR1)
    1.1.1.197  15-hydroxyprostaglandin dehydrogenase (NADP+)
     873 (CBR1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR
Other DBs
NCBI-GeneID: 873
NCBI-ProteinID: NP_001748
OMIM: 114830
HGNC: 1548
Ensembl: ENSG00000159228
UniProt: P16152 A0A384NL53
Structure
Position
21:36070024..36073164
AA seq 277 aa
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
NT seq 834 nt   +upstreamnt  +downstreamnt
atgtcgtccggcatccatgtagcgctggtgactggaggcaacaagggcatcggcttggcc
atcgtgcgcgacctgtgccggctgttctcgggggacgtggtgctcacggcgcgggacgtg
acgcggggccaggcggccgtacagcagctgcaggcggagggcctgagcccgcgcttccac
cagctggacatcgacgatctgcagagcatccgcgccctgcgcgacttcctgcgcaaggag
tacgggggcctggacgtgctggtcaacaacgcgggcatcgccttcaaggttgctgatccc
acaccctttcatattcaagctgaagtgacgatgaaaacaaatttctttggtacccgagat
gtgtgcacagaattactccctctaataaaaccccaagggagagtggtgaacgtatctagc
atcatgagcgtcagagcccttaaaagctgcagcccagagctgcagcagaagttccgcagt
gagaccatcactgaggaggagctggtggggctcatgaacaagtttgtggaggatacaaag
aagggagtgcaccagaaggagggctggcccagcagcgcatacggggtgacgaagattggc
gtcaccgttctgtccaggatccacgccaggaaactgagtgagcagaggaaaggggacaag
atcctcctgaatgcctgctgcccagggtgggtgagaactgacatggcgggacccaaggcc
accaagagcccagaagaaggtgcagagacccctgtgtacttggcccttttgcccccagat
gctgagggtccccatggacaatttgtttcagagaagagagttgaacagtggtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (7)   
   KEGG ENZYME (3)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (28)   
   RefSeq(nuc) (2)   
   GenBank (13)   
   EMBL (13)   
3D Structure (6)   
   PDB (6)   
Protein domain (3)   
   Pfam (3)   
All databases (85)   

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