KEGG   Homo sapiens (human): 8743
Entry
8743              CDS       T01001                                 
Symbol
TNFSF10, APO2L, Apo-2L, CD253, TANCR, TL2, TNLG6A, TRAIL
Name
(RefSeq) TNF superfamily member 10
  KO
K04721  tumor necrosis factor ligand superfamily member 10
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04068  FoxO signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa04650  Natural killer cell mediated cytotoxicity
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05164  Influenza A
hsa05417  Lipid and atherosclerosis
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06231  Apoptosis (cancer)
nt06263  Hepatocellular carcinoma
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
nt06527  Necroptosis
  Element
N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
N01631  TNFSF10-RIPK1/3 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    8743 (TNFSF10)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    8743 (TNFSF10)
   04061 Viral protein interaction with cytokine and cytokine receptor
    8743 (TNFSF10)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    8743 (TNFSF10)
   04217 Necroptosis
    8743 (TNFSF10)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    8743 (TNFSF10)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    8743 (TNFSF10)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    8743 (TNFSF10)
   05132 Salmonella infection
    8743 (TNFSF10)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    8743 (TNFSF10)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8743 (TNFSF10)
   04052 Cytokines and neuropeptides [BR:hsa04052]
    8743 (TNFSF10)
   04090 CD molecules [BR:hsa04090]
    8743 (TNFSF10)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   8743 (TNFSF10)
Cytokines and neuropeptides [BR:hsa04052]
 Cytokines
  Tumor necrosis fators
   8743 (TNFSF10)
CD molecules [BR:hsa04090]
 Proteins
  8743 (TNFSF10)
SSDB
Motif
Pfam: TNF
Other DBs
NCBI-GeneID: 8743
NCBI-ProteinID: NP_003801
OMIM: 603598
HGNC: 11925
Ensembl: ENSG00000121858
UniProt: P50591 Q6IBA9
Structure
Position
3:complement(172505508..172523430)
AA seq 281 aa
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKE
DDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQ
RVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKG
FYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLY
SIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
NT seq 846 nt   +upstreamnt  +downstreamnt
atggctatgatggaggtccaggggggacccagcctgggacagacctgcgtgctgatcgtg
atcttcacagtgctcctgcagtctctctgtgtggctgtaacttacgtgtactttaccaac
gagctgaagcagatgcaggacaagtactccaaaagtggcattgcttgtttcttaaaagaa
gatgacagttattgggaccccaatgacgaagagagtatgaacagcccctgctggcaagtc
aagtggcaactccgtcagctcgttagaaagatgattttgagaacctctgaggaaaccatt
tctacagttcaagaaaagcaacaaaatatttctcccctagtgagagaaagaggtcctcag
agagtagcagctcacataactgggaccagaggaagaagcaacacattgtcttctccaaac
tccaagaatgaaaaggctctgggccgcaaaataaactcctgggaatcatcaaggagtggg
cattcattcctgagcaacttgcacttgaggaatggtgaactggtcatccatgaaaaaggg
ttttactacatctattcccaaacatactttcgatttcaggaggaaataaaagaaaacaca
aagaacgacaaacaaatggtccaatatatttacaaatacacaagttatcctgaccctata
ttgttgatgaaaagtgctagaaatagttgttggtctaaagatgcagaatatggactctat
tccatctatcaagggggaatatttgagcttaaggaaaatgacagaatttttgtttctgta
acaaatgagcacttgatagacatggaccatgaagccagtttttttggggcctttttagtt
ggctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (15)   
   KEGG NETWORK (15)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (30)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (36)   
   RefSeq(nuc) (4)   
   GenBank (16)   
   EMBL (16)   
3D Structure (7)   
   PDB (7)   
Protein domain (1)   
   Pfam (1)   
All databases (123)   

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