KEGG   Homo sapiens (human): 8797
Entry
8797              CDS       T01001                                 
Symbol
TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1
Name
(RefSeq) TNF receptor superfamily member 10a
  KO
K04722  tumor necrosis factor receptor superfamily member 10A/B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
hsa04217  Necroptosis
hsa04650  Natural killer cell mediated cytotoxicity
hsa05130  Pathogenic Escherichia coli infection
hsa05132  Salmonella infection
hsa05164  Influenza A
hsa05417  Lipid and atherosclerosis
Network
nt06527  Necroptosis
  Element
N01631  TNFSF10-RIPK1/3 signaling pathway
Drug target
Mapatumumab: D04858
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    8797 (TNFRSF10A)
   04061 Viral protein interaction with cytokine and cytokine receptor
    8797 (TNFRSF10A)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    8797 (TNFRSF10A)
   04217 Necroptosis
    8797 (TNFRSF10A)
   04115 p53 signaling pathway
    8797 (TNFRSF10A)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    8797 (TNFRSF10A)
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    8797 (TNFRSF10A)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    8797 (TNFRSF10A)
   05132 Salmonella infection
    8797 (TNFRSF10A)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    8797 (TNFRSF10A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors [BR:hsa04050]
    8797 (TNFRSF10A)
   04090 CD molecules [BR:hsa04090]
    8797 (TNFRSF10A)
Cytokine receptors [BR:hsa04050]
 Tumor necrosis factor receptors
  TNF receptor superfamily
   8797 (TNFRSF10A)
CD molecules [BR:hsa04090]
 Proteins
  8797 (TNFRSF10A)
SSDB
Motif
Pfam: Death TNFR_c6 DUF6721
Other DBs
NCBI-GeneID: 8797
NCBI-ProteinID: NP_003835
OMIM: 603611
HGNC: 11904
Ensembl: ENSG00000104689
UniProt: O00220
Structure
Position
8:complement(23190452..23225102)
AA seq 468 aa
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMG
QHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGT
QQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPC
TTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNI
WVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEIL
SNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADP
TETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTG
RNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
NT seq 1407 nt   +upstreamnt  +downstreamnt
atggcgccaccaccagctagagtacatctaggtgcgttcctggcagtgactccgaatccc
gggagcgcagcgagtgggacagaggcagccgcggccacacccagcaaagtgtggggctct
tccgcggggaggattgaaccacgaggcgggggccgaggagcgctccctacctccatggga
cagcacggacccagtgcccgggcccgggcagggcgcgccccaggacccaggccggcgcgg
gaagccagccctcggctccgggtccacaagaccttcaagtttgtcgtcgtcggggtcctg
ctgcaggtcgtacctagctcagctgcaaccatcaaacttcatgatcaatcaattggcaca
cagcaatgggaacatagccctttgggagagttgtgtccaccaggatctcatagatcagaa
catcctggagcctgtaaccggtgcacagagggtgtgggttacaccaatgcttccaacaat
ttgtttgcttgcctcccatgtacagcttgtaaatcagatgaagaagagagaagtccctgc
accacgaccaggaacacagcatgtcagtgcaaaccaggaactttccggaatgacaattct
gctgagatgtgccggaagtgcagcagagggtgccccagagggatggtcaaggtcaaggat
tgtacgccctggagtgacatcgagtgtgtccacaaagaatcaggcaatggacataatata
tgggtgattttggttgtgactttggttgttccgttgctgttggtggctgtgctgattgtc
tgttgttgcatcggctcaggttgtggaggggaccccaagtgcatggacagggtgtgtttc
tggcgcttgggtctcctacgagggcctggggctgaggacaatgctcacaacgagattctg
agcaacgcagactcgctgtccactttcgtctctgagcagcaaatggaaagccaggagccg
gcagatttgacaggtgtcactgtacagtccccaggggaggcacagtgtctgctgggaccg
gcagaagctgaagggtctcagaggaggaggctgctggttccagcaaatggtgctgacccc
actgagactctgatgctgttctttgacaagtttgcaaacatcgtgccctttgactcctgg
gaccagctcatgaggcagctggacctcacgaaaaatgagatcgatgtggtcagagctggt
acagcaggcccaggggatgccttgtatgcaatgctgatgaaatgggtcaacaaaactgga
cggaacgcctcgatccacaccctgctggatgccttggagaggatggaagagagacatgca
agagagaagattcaggacctcttggtggactctggaaagttcatctacttagaagatggc
acaggctctgccgtgtccttggagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (78)   

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