KEGG   Homo sapiens (human): 8874
Entry
8874              CDS       T01001                                 
Symbol
ARHGEF7, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Name
(RefSeq) Rho guanine nucleotide exchange factor 7
  KO
K13710  Rho guanine nucleotide exchange factor 7
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
hsa05135  Yersinia infection
Network
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
  Element
N01070  ITGA/B-FAK-CDC42 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    8874 (ARHGEF7)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    8874 (ARHGEF7)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8874 (ARHGEF7)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    8874 (ARHGEF7)
SSDB
Motif
Pfam: RhoGEF67_u2 RhoGEF SH3_2 SH3_1 SH3_9 RhoGEF67_u1 PH CH
Other DBs
NCBI-GeneID: 8874
NCBI-ProteinID: NP_001106983
OMIM: 605477
HGNC: 15607
Ensembl: ENSG00000102606
UniProt: Q14155 Q5W9H1
Structure
Position
13:111114619..111305734
AA seq 803 aa
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEP
RSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNK
VLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMT
DNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVRE
VKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRP
LQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL
YLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKEL
ERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNV
TYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSE
NHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSH
PVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPP
LRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAY
CTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIW
TAHSYRMGSTSRKSCCSYISHQN
NT seq 2412 nt   +upstreamnt  +downstreamnt
atgaattccgccgagcaaaccgttacgtggctcatcactctgggggtgctggagtcgccc
aaaaaaaccatctcggacccggagggctttctgcaggcgtcgctgaaggatggggtggtc
ctctgcaggctgctggagcgcctgctccccgggaccatcgagaaagtctaccccgagccc
cggagcgagagcgagtgcctgagcaacatccgcgagttcctgcgcggctgcggggcttcc
ctgcggctggagctcctgtttcctccttcccagcctcctcagcatctggtaaccaccatt
ctcttgtctgcttctacgtttgatgcaaatgatttgtatcaggggcagaattttaacaag
gtcctcagttccttagtgactctaaataaagtaacagcagacatcgggctggggagtgac
tccgtgtgtgcccggccctcgtctcaccgcataaagtcttttgactcccttggatcacag
tctttgcacactcggacttcaaaactgttccagggccagtatcggagtttggacatgacc
gataatagcaacaatcaactggtagtaagagcaaagtttaacttccagcagaccaatgag
gacgagctttccttctcaaaaggagacgtcatccatgtcacccgtgtggaagagggaggc
tggtgggagggcacactcaacggccggaccggctggttccccagcaactacgtgcgcgag
gtcaaggccagcgagaagcctgtgtctcccaaatcaggaacactgaagagccctcccaaa
ggatttgatacgactgccataaacaaaagctattacaatgtggtgctacagaatatttta
gaaacagaaaatgaatattctaaagaacttcagactgtgctttcaacgtacctacggcca
ttgcagaccagtgagaagttaagttcagcaaacatttcatatttaatgggaaatctagaa
gaaatatgttctttccagcaaatgctcgtacagtctttagaagaatgcaccaagttgccc
gaagctcagcagagagtcggaggctgctttttaaacctgatgccacagatgaaaaccctg
tacctcacgtattgtgccaatcacccttctgcagtgaatgtcctcacggaacacagtgag
gagttgggggagttcatggagaccaaaggtgccagcagccctgggattctcgtgctgacc
acgggcctgagcaaacccttcatgcgcctggataaataccctacgctgctcaaagagctc
gagagacacatggaggattatcatacagatagacaagatattcaaaaatccatggctgcc
ttcaaaaacctttcagcccaatgtcaagaagtccggaagaggaaagagcttgagctgcag
atcctgacggaagccatccggaactgggagggcgatgacattaaaactctgggcaacgtc
acttacatgtcccaggtcctgattcagtgtgccggaagtgaggaaaagaatgaaagatat
cttctactcttcccaaatgttttgctaatgttgtctgccagtcctaggatgagtggcttt
atctatcagggaaagcttccaacgacaggaatgacaatcacaaagcttgaggacagtgaa
aatcatagaaatgcatttgaaatatcagggagcatgattgagcggatattagtgtcgtgc
aacaaccagcaggatctgcaggaatgggtggagcacctacagaagcaaacgaaggtcacg
tctgtgggaaaccccaccataaagcctcattcagtgccatctcataccctcccctcccac
ccggtcactccgtccagcaagcacgcagacagcaagcccgcgccgctgacgcccgcctac
cacacgctgccccacccctcccaccacggcaccccgcacaccaccatcaactggggaccc
ctggagcctccgaaaacacccaagccctggagcctgagctgcctgcggcccgcgcctccc
ctccggccctcagctgctctctgctacaaggaggatcttagtaagagccctaagaccatg
aaaaagctgctgcccaagcgcaaacctgaacggaagccttcagatgaggagttcgcgtcc
cggaaaagcacagctgctttggaagaagatgctcagattctgaaagtcattgaagcttac
tgcaccagcgccaaaacaaggcaaacactcaattcaacatggcaaggcactgacctgatg
cataatcacgtcttggctgatgatgaccaaccaagcctagactccctggggcgtcgcagt
agcctttctcgtttggagccttcagacctctcggaagactctgactatgacagtatatgg
acagcccatagttacagaatgggttctacatctcgtaagagctgttgctcatatatctct
caccagaactaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (93)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (90)   
DNA sequence (158)   
   RefSeq(nuc) (92)   
   GenBank (33)   
   EMBL (33)   
3D Structure (4)   
   PDB (4)   
Protein domain (8)   
   Pfam (8)   
All databases (292)   

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