KEGG   Homo sapiens (human): 8940
Entry
8940              CDS       T01001                                 
Symbol
TOP3B, TOP3B1
Name
(RefSeq) DNA topoisomerase III beta
  KO
K03165  DNA topoisomerase III [EC:5.6.2.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    8940 (TOP3B)
   03460 Fanconi anemia pathway
    8940 (TOP3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    8940 (TOP3B)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    8940 (TOP3B)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.1  DNA topoisomerase
     8940 (TOP3B)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Topoisomerases
   8940 (TOP3B)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Bloom's syndrome complex (BTR)
     8940 (TOP3B)
   FA (Fanconi anemia) pathway
     8940 (TOP3B)
SSDB
Motif
Pfam: Topoisom_bac Toprim
Other DBs
NCBI-GeneID: 8940
NCBI-ProteinID: NP_001269041
OMIM: 603582
HGNC: 11993
Ensembl: ENSG00000100038
UniProt: O95985
Structure
Position
22:complement(21957025..21982787)
AA seq 862 aa
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH
VMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDK
EGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDA
RQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETY
WVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLA
LNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANH
PYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATV
SHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGE
VKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNL
GIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSI
AGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKL
YKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSM
LGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLD
VDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARR
PPGKPNPRRPKDKMSALAAYFV
NT seq 2589 nt   +upstreamnt  +downstreamnt
atgaagactgtgctcatggttgctgaaaagccgtccttggcacagtcaattgccaaaatc
ctctctagagggagcctgtcctcacacaaagggctgaacggggcctgctcagtccacgag
tacactgggacctttgctggccagccagtgcgcttcaagatgacgtctgtctgtggtcac
gtgatgaccctggatttcctgggaaaatacaacaaatgggacaaagtggaccccgcagaa
ctgttcagccaagctcccacggagaagaaagaagctaaccccaagctgaacatggtgaag
ttcctgcaggtggagggcagaggctgcgactacatcgtgctgtggctggactgcgacaag
gagggggagaacatctgctttgaggttcttgatgctgttctgcccgtcatgaacaaggcc
catggtggcgagaagaccgtgttccgggccaggtttagctccatcacggacacagacatc
tgtaatgccatggcctgcctaggcgagcctgaccacaacgaggcgctctcagtggatgct
cgccaggagctggacctgcgaatcggctgtgcattcaccaggtttcagactaaatatttc
caggggaaatacggtgatttagacagctctctcatctcctttgggccgtgtcagactcca
accctgggattctgtgtggagagacatgataaaatccagtccttcaaaccagagacctac
tgggtgctgcaggccaaggttaacactgacaaagacagatctctccttttggactgggac
cgagtaagagtgtttgaccgggagatcgcacagatgtttttaaacatgacaaagctggag
aaggaagcccaggtggaggccacaagcaggaaagaaaaggccaagcagaggcccctggcc
ctgaacactgtggagatgctgcgtgtggccagctcttctctgggcatggggccgcagcac
gccatgcagacggctgagcggctctacacgcaaggctacatcagctacccacggacagag
accacccactaccctgagaactttgacctgaagggctctctgcggcagcaggccaaccac
ccctactgggccgacacggtgaagcggttgttagcagaaggtatcaaccgcccgcggaaa
ggccatgacgccggcgaccatccccccatcacccccatgaagtctgccacagaggccgaa
ttagggggtgacgcgtggcggctctatgagtacatcaccagacacttcatcgccacggtc
agccatgactgcaagtacctgcagagcaccatctccttcagaattgggcccgagctcttc
acctgctccgggaagaccgtcctctcaccaggcttcacggaggtcatgccctggcagagc
gtgcccctggaggagagcctgcccacttgccagcggggtgatgccttccctgtgggcgag
gtgaagatgctggagaagcagacgaacccacccgactacctgacggaggccgagctcatc
acgctcatggagaagcatggcatcggcacggatgccagcatccctgtgcatatcaacaac
atctgccagcgcaactatgtcacggtggagagcgggcgccggctcaagcccaccaacctc
ggcatcgtcctggtgcacggctactataagattgatgcagagctggtgctccccaccatc
cgcagtgcagtggagaagcagctgaacctgatcgcccagggcaaggccgactaccgccag
gtcctgggccacaccctggacgtgttcaagaggaagttccactactttgtcgactccatt
gctggcatggatgagttgatggaggtgtctttctcgcccctggcggccacaggcaagccc
ctctcacgctgtgggaagtgccaccgcttcatgaagtacatccaggccaagccaagccgc
ctgcactgctcccactgcgatgagacctacacgctcccccagaacggcaccatcaagctc
tacaaggagctccgctgccctctggatgacttcgagctggtcctgtggtcatcaggctct
cggggcaagagctacccgctgtgcccctactgctacaaccacccacccttccgagacatg
aagaaaggcatgggctgcaacgagtgtacgcacccctcctgccagcactcgctgagcatg
ctgggcatcggccagtgcgtggaatgtgagagcggggtgctggtgctggaccccacctcg
ggccccaagtggaaggtggcctgcaacaagtgcaacgtggtagcgcactgcttcgagaac
gcccaccgcgtgcgggtgtccgccgacacctgcagtgtctgtgaggccgccttgcttgat
gtggacttcaacaaggccaagtccccactcccgggcgatgagacgcagcacatgggctgc
gtcttttgtgaccccgtcttccaggagctggtggagctgaagcatgcggcctcctgccac
cccatgcaccgcggtggaccagggagaaggcagggtcgagggcggggccgggccaggagg
ccccctgggaagcccaaccccagacggcccaaggacaagatgtcagccctggccgcctac
tttgtatga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (66)   
   RefSeq(nuc) (10)   
   GenBank (28)   
   EMBL (28)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (107)   

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