KEGG   Homo sapiens (human): 8972
Entry
8972              CDS       T01001                                 
Symbol
MGAM, MG, MGA
Name
(RefSeq) maltase-glucoamylase
  KO
K12047  maltase-glucoamylase [EC:3.2.1.20 3.2.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00052  Galactose metabolism
hsa00500  Starch and sucrose metabolism
hsa01100  Metabolic pathways
hsa04973  Carbohydrate digestion and absorption
Network
nt06017  Glycogen metabolism
  Element
N00720  Glycogen degradation (amylase)
Drug target
Acarbose: D00216<JP/US>
Emiglitate: D09779
Miglitol: D00625<JP/US>
Voglibose: D01665<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00052 Galactose metabolism
    8972 (MGAM)
   00500 Starch and sucrose metabolism
    8972 (MGAM)
 09150 Organismal Systems
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    8972 (MGAM)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.2  Glycosylases
   3.2.1  Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
    3.2.1.3  glucan 1,4-alpha-glucosidase
     8972 (MGAM)
    3.2.1.20  alpha-glucosidase
     8972 (MGAM)
SSDB
Motif
Pfam: Glyco_hydro_31_2nd Glyco_hydro_31_3rd Trefoil Gal_mutarotas_2
Other DBs
NCBI-GeneID: 8972
NCBI-ProteinID: NP_004659
OMIM: 154360
HGNC: 7043
Ensembl: ENSG00000257335
UniProt: O43451
Structure
Position
7:141986518..142106747
AA seq 1857 aa
MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTP
DPGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWN
PQGAVSVPWCYYSKNHSYHVEGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTS
NRFHFKLTDQTNNRFEVPHEHVQSFSGNAAASLTYQVEISRQPFSIKVTRRSNNRVLFDS
SIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNWKTWPIFNRDTTPNGNGTNLY
GAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYVFLGNTPEQVV
QEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDER
RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNS
SDGVTPLIGEVWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGS
VSGCSTNNLNNPPFTPRILDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKT
VFPNKRSFILTRSTFAGSGKFAAHWLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICG
FALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLL
PYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAY
VPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGL
IIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFN
EIKILGTEEPSNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRD
EEKIDCYPDENGASAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADIS
LKSSVYANAFPSTPVNPLRLDVTYHKNEMLQFKIYDPNKNRYEVPVPLNIPSMPSSTPEG
QLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFIRISTRLPSKYLYGFGETEHR
SYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPL
PALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIA
SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAI
SGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYV
AFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDAS
LNHPPYMPHLESRDRGLSSKTLCMESQQILPDGSLVQHYNVHNLYGWSQTRPTYEAVQEV
TGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYTGADICGFF
QDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQTRYTLLPYLY
TLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRA
RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIAL
DDEGTAGGWLFWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIE
IWGVGSVPVTSVSISVSGMVITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL
NT seq 5574 nt   +upstreamnt  +downstreamnt
atggcaagaaagaagctgaaaaaatttactactttggagattgtgctcagtgttcttctg
cttgtgttgtttatcatcagtattgttctaattgtgcttttagccaaagagtcactgaaa
tcaacagccccagatcctgggacaactggtaccccagatcctgggacaactggtacccca
gatcctggaacaactggtaccacacatgctaggacaacgggtcccccagatcctggaaca
actggtaccactcctgtttctgctgaatgtccagtggtaaatgaattggaacgaattaat
tgcatccctgaccagccgccaacaaaggccacatgtgaccaacgtggctgttgctggaat
ccccagggagctgtaagtgttccctggtgctactattccaagaatcatagctaccatgta
gagggcaaccttgtcaacacaaatgcaggattcacagcccggttgaaaaatctgccttct
tcaccagtgtttggaagcaatgttgacaatgttcttctcacagcagaatatcagacatct
aatcgtttccactttaagttgactgaccaaaccaataacaggtttgaagtgccccacgaa
cacgtgcagtccttcagtggaaatgctgctgcttctttgacctaccaagttgaaatctcc
agacagccatttagcatcaaagtgaccagaagaagcaacaatcgtgttttgtttgactcg
agcattgggcccctactgtttgctgaccagttcttgcagctctccactcgactgcctagc
actaacgtgtatggcctgggagagcatgtgcaccagcagtatcggcatgatatgaattgg
aagacctggcccatatttaacagagacacaactcccaatggaaacggaactaatttgtat
ggtgcgcagacattcttcttgtgccttgaagatgctagtggattgtcctttggggtgttt
ctgatgaacagcaatgccatggaggttgtccttcagcctgcgccagccatcacttaccgc
accattgggggcattctcgacttctatgtgttcttgggaaacactccagagcaagttgtt
caagaatatctagagctcattgggcggccagcccttccctcctactgggcgcttggattt
cacctcagtcgttacgaatatggaaccttagacaacatgagggaagtcgtggagagaaat
cgcgcagcacagctcccttatgatgttcagcatgctgatattgattatatggatgagaga
agggacttcacttatgattcagtggattttaaaggcttccctgaatttgtcaacgagtta
cacaataatggacagaagcttgtcatcattgtggatccagccatctccaacaactcttcc
tcaagtaaaccctatggcccatatgacaggggttcagatatgaagatatgggtgaatagt
tcagatggagtgactccactcattggggaggtctggcctggacaaactgtgtttcctgat
tataccaatcccaactgtgctgtttggtggacaaaggaatttgagctttttcacaatcaa
gtagagtttgatggaatctggattgatatgaatgaagtctccaactttgttgatggttcg
gtctcaggatgttccacaaacaacctaaataatcccccattcactcccagaatcctggat
gggtacctgttctgcaagactctctgtatggatgcagtgcagcactggggcaagcagtat
gacattcacaatctgtatggctactccatggcggtcgccacagcagaagctgccaagact
gtgttccctaataagagaagcttcattctgacccgttctacctttgcgggctctggcaag
tttgcagcacattggttaggagacaacactgccacctgggatgacctgagatggtccatc
cctggcgtgcttgagttcaacctttttggcatcccaatggtgggtcctgacatatgtggc
tttgctttggacacccctgaggagctctgtaggcggtggatgcagttgggtgcattttat
ccgttttctagaaatcacaatggccaaggctacaaggaccaggatcctgcctcctttgga
gctgactccctgctgttgaattcctccaggcactaccttaacatccgctatactctattg
ccctacctatacaccctcttcttccgtgctcacagccgaggggacacggtggccaggccc
cttttgcatgagttctacgaggacaacagcacttgggatgtgcaccaacagttcttatgg
gggcccggcctcctcatcactccagttctggatgaaggtgcagagaaagtgatggcatat
gtgcctgatgctgtctggtatgactacgagactgggagccaagtgagatggaggaagcaa
aaagtcgagatggaacttcctggagacaaaattggacttcaccttcgaggaggctacatc
ttccccacacagcagccaaatacaaccactctggccagtcgaaagaaccctcttggtctt
atcattgccctagatgagaacaaagaagcaaaaggagaacttttctgggataatggggaa
acgaaggatactgtggccaataaagtgtatcttttatgtgagttttctgtcactcaaaac
cgcttggaggtgaatatttcacaatcaacctacaaggaccccaataatttagcatttaat
gagattaaaattcttgggacggaggaacctagcaatgttacagtgaaacacaatggtgtc
ccaagtcagacttctcctacagtcacttatgattctaacctgaaggttgccattatcaca
gatattgatcttctcctgggagaagcatacacagtggaatggagcataaagataagggat
gaagaaaaaatagactgttaccctgatgagaatggtgcttctgccgaaaactgcactgcc
cgtggctgtatctgggaggcatccaattcttctggagtccctttttgctattttgtcaac
gacctatactctgtcagtgatgttcagtataattcccatggggccacagctgacatctcc
ttaaagtcttccgtttatgccaatgccttcccctccacacccgtgaacccccttcgcctg
gatgtcacttaccataagaatgaaatgctgcagttcaagatttatgatcccaacaagaat
cggtatgaagttccagtccctctgaacatacccagcatgccatccagcacccctgagggt
caactctatgatgtgctcattaagaagaatccatttgggattgaaattcgccggaagagt
acaggcactataatttgggactctcagctccttggctttaccttcagtgacatgtttatc
cgcatctccacccgccttccctccaagtacctctatggctttggggaaactgagcacagg
tcctataggagagacttggagtggcacacttgggggatgttctcccgagaccagccccca
gggtacaagaagaattcctatggtgtccacccctactacatggggctggaggaggacggc
agtgcccatggagtgctcctgctgaacagcaatgccatggatgtgacgttccagcccctg
cctgccttgacataccgcaccacagggggagttctggacttttatgtgttcttggggccg
actccagagcttgtcacccagcagtacactgagttgattggccggcctgtgatggtacct
tactggtctttggggttccagctgtgtcgctatggctaccagaatgactctgagatcgcc
agcttgtatgatgagatggtggctgcccagatcccttatgatgtgcagtactcagacatc
gactacatggagcggcagctggacttcaccctcagccccaagtttgctgggtttccagct
ctgatcaatcgcatgaaggctgatgggatgcgggtcatcctcattctggatccagccatt
tctggcaatgagacacagccttatcctgccttcactcggggcgtggaggatgacgtcttc
atcaaatacccaaatgatggagacattgtctggggaaaggtctggcctgattttcctgat
gttgttgtgaatgggtctctagactgggacagccaagtggagctatatcgagcttatgtg
gccttcccagactttttccgtaattcaactgccaagtggtggaagagggaaatagaagaa
ctatacaacaatccacagaatccagagaggagcttgaagtttgatggcatgtggattgat
atgaatgaaccatcaagcttcgtgaatggggcagtttctccaggctgcagggacgcctct
ctgaaccaccctccctacatgccacatttggagtccagggacaggggcctgagcagcaag
accctttgtatggagagtcagcagatcctcccagacggctccctggtgcagcactacaac
gtgcacaacctgtatgggtggtcccagaccagacccacatacgaagccgtgcaggaggtg
acgggacagcgaggggtcgtcatcacccgctccacatttccctcttctggccgctgggca
ggacattggctgggagacaacacggccgcatgggatcagctgaagaagtctatcattggc
atgatggagttcagcctcttcggcatatcctatacgggagcagatatctgtgggttcttt
caagatgctgaatatgagatgtgtgttcgctggatgcagctgggggccttttaccccttc
tcaagaaaccacaacaccattgggaccaggagacaagaccctgtgtcctgggatgttgct
tttgtgaatatttccagaactgtcctgcagaccagatacaccctgttgccatatctgtat
accttgatgcataaggcccacacggagggcgtcactgttgtgcggcctctgctccatgag
tttgtgtcagaccaggtgacatgggacatagacagtcagttcctgctgggcccagccttc
ctggtcagccctgtcctggagcgtaatgccagaaatgtcactgcatatttccctagagcc
cgctggtatgattactacacgggtgtggatattaatgcaagaggagagtggaagaccttg
ccagcccctcttgaccacattaatcttcatgtccgtgggggctacatcctgccctggcaa
gagcctgcactgaacacccacttaagccgccagaaattcatgggcttcaaaattgccttg
gatgatgaaggaactgctgggggctggctcttctgggatgatgggcaaagcattgatacc
tatgggaaaggactctattacttggccagcttttctgccagccagaatacgatgcaaagc
catataattttcaacaattacatcactggtacaaatcctttgaaactgggctacattgaa
atctggggagtgggcagtgtccccgttaccagtgtcagcatctctgtgagtggcatggtc
ataacaccctccttcaacaatgaccccacgacacaggtattaagcatcgatgtgactgac
agaaacatcagcctacataattttacttcattgacgtggataagcactctgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (4)   
   KEGG DRUG (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG ORTHOLOGY (1)   
   RefGene (36)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (22)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (20)   
DNA sequence (26)   
   RefSeq(nuc) (20)   
   GenBank (3)   
   EMBL (3)   
3D Structure (12)   
   PDB (12)   
Protein domain (4)   
   Pfam (4)   
All databases (139)   

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