KEGG   Homo sapiens (human): 8974
Entry
8974              CDS       T01001                                 
Symbol
P4HA2, MYP25, lncRNA-PE
Name
(RefSeq) prolyl 4-hydroxylase subunit alpha 2
  KO
K00472  prolyl 4-hydroxylase [EC:1.14.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
Disease
H02041  Myopia
Drug target
Lufironil: D04793
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    8974 (P4HA2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.2  procollagen-proline 4-dioxygenase
     8974 (P4HA2)
SSDB
Motif
Pfam: P4Ha_N 2OG-FeII_Oxy_3 TPR_2 TPR_14 SPO22 Fis1_TPR_C
Other DBs
NCBI-GeneID: 8974
NCBI-ProteinID: NP_001136071
OMIM: 600608
HGNC: 8547
Ensembl: ENSG00000072682
UniProt: O15460 Q05DA4
Structure
Position
5:complement(132190147..132227853)
AA seq 535 aa
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKS
WANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQR
QFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEG
DYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSH
ERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVK
LTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK
LARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVAN
YGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKK
GTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD
NT seq 1608 nt   +upstreamnt  +downstreamnt
atgaaactctgggtgtctgcattgctgatggcctggtttggtgtcctgagctgtgtgcag
gccgaattcttcacctctattgggcacatgactgacctgatttatgcagagaaagagctg
gtgcagtctctgaaagagtacatccttgtggaggaagccaagctttccaagattaagagc
tgggccaacaaaatggaagccttgactagcaagtcagctgctgatgctgagggctacctg
gctcaccctgtgaatgcctacaaactggtgaagcggctaaacacagactggcctgcgctg
gaggaccttgtcctgcaggactcagctgcaggttttatcgccaacctctctgtgcagcgg
cagttcttccccactgatgaggacgagataggagctgccaaagccctgatgagacttcag
gacacatacaggctggacccaggcacaatttccagaggggaacttccaggaaccaagtac
caggcaatgctgagtgtggatgactgctttgggatgggccgctcggcctacaatgaaggg
gactattatcatacggtgttgtggatggagcaggtgctaaagcagcttgatgccggggag
gaggccaccacaaccaagtcacaggtgctggactacctcagctatgctgtcttccagttg
ggtgatctgcaccgtgccctggagctcacccgccgcctgctctcccttgacccaagccac
gaacgagctggagggaatctgcggtactttgagcagttattggaggaagagagagaaaaa
acgttaacaaatcagacagaagctgagctagcaaccccagaaggcatctatgagaggcct
gtggactacctgcctgagagggatgtttacgagagcctctgtcgtggggagggtgtcaaa
ctgacaccccgtagacagaagaggcttttctgtaggtaccaccatggcaacagggcccca
cagctgctcattgcccccttcaaagaggaggacgagtgggacagcccgcacatcgtcagg
tactacgatgtcatgtctgatgaggaaatcgagaggatcaaggagatcgcaaaacctaaa
cttgcacgagccaccgttcgtgatcccaagacaggagtcctcactgtcgccagctaccgg
gtttccaaaagctcctggctagaggaagatgatgaccctgttgtggcccgagtaaatcgt
cggatgcagcatatcacagggttaacagtaaagactgcagaattgttacaggttgcaaat
tatggagtgggaggacagtatgaaccgcacttcgacttctctaggaatgatgagcgagat
actttcaagcatttagggacggggaatcgtgtggctactttcttaaactacatgagtgat
gtagaagctggtggtgccaccgtcttccctgatctgggggctgcaatttggcctaagaag
ggtacagctgtgttctggtacaacctcttgcggagcggggaaggtgactaccgaacaaga
catgctgcctgccctgtgcttgtgggctgcaagtgggtctccaataagtggttccatgaa
cgaggacaggagttcttgagaccttgtggatcaacagaagttgactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (35)   
   KEGG ORTHOLOGY (1)   
   RefGene (24)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (12)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (29)   
   RefSeq(nuc) (9)   
   GenBank (10)   
   EMBL (10)   
3D Structure (6)   
   PDB (6)   
Protein domain (6)   
   Pfam (6)   
All databases (105)   

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