KEGG   Homo sapiens (human): 8997
Entry
8997              CDS       T01001                                 
Symbol
KALRN, ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, KALNC2, TRAD
Name
(RefSeq) kalirin RhoGEF kinase
  KO
K15048  kalirin [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Disease
H01742  Coronary artery disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    8997 (KALRN)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    8997 (KALRN)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    8997 (KALRN)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     8997 (KALRN)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  Trio family [OT]
   8997 (KALRN)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    8997 (KALRN)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   8997 (KALRN)
SSDB
Motif
Pfam: RhoGEF Pkinase Spectrin SH3-RhoG_link PK_Tyr_Ser-Thr I-set PH Ig_3 fn3 ig CRAL_TRIO_2 IQ_SEC7_PH PH_10 SH3_2 SH3_1 PH_19 CRAL_TRIO Ig_2 PH_13 SH3_9 V-set Pur_ac_phosph_N RL11D T4_Rnl2_C
Other DBs
NCBI-GeneID: 8997
NCBI-ProteinID: NP_001019831
OMIM: 604605
HGNC: 4814
Ensembl: ENSG00000160145
UniProt: O60229
Structure
Position
3:124033369..124726325
AA seq 2986 aa
MTDRFWDQWYLWYLRLLRLLDRGSFRNDGLKASDVLPILKEKVAFVSGGRDKRGGPILTF
PARSNHDRIRQEDLRKLVTYLASVPSEDVCKRGFTVIIDMRGSKWDLIKPLLKTLQEAFP
AEIHVALIIKPDNFWQKQKTNFGSSKFIFETSMVSVEGLTKLVDPSQLTEEFDGSLDYNH
EEWIELRLSLEEFFNSAVHLLSRLEDLQEMLARKEFPVDVEGSRRLIDEHTQLKKKVLKA
PVEELDREGQRLLQCIRCSDGFSGRNCIPGSADFQSLVPKITSLLDKLHSTRQHLHQMWH
VRKLKLDQCFQLRLFEQDAEKMFDWISHNKELFLQSHTEIGVSYQYALDLQTQHNHFAMN
SMNAYVNINRIMSVASRLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILAMSAVF
HQKAEQFLSGVDAWCKMCSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKALLD
VLQRPLSPGNSESLTATANYSKAVHQVLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCV
FQQDVQQVLDWIENHGEAFLSKHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEA
AEQLAQTGECDPEEIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDL
QKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGEDLIQQLRSAPPSLGEPSE
ARDSAVSNNKTPHSSSISHIESVLQQLDDAQVQMEELFHERKIKLDIFLQLRIFEQYTIE
VTAELDAWNEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIT
EVQASGIELICEKDIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVK
QVLGWIRNGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQ
QKAEVLLQAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE
SLEQEYRRDEDWCGGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYI
HRNNVSMPSVASHTRGPEQQVKAILSELLQRENRVLHFWTLKKRRLDQCQQYVVFERSAK
QALDWIQETGEFYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVE
KGHIHATEIRKWVTTVDKHYRDFSLRMGKYRYSLEKALGVNTEDNKDLELDIIPASLSDR
EVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPP
GILNKEHIIFGNIQEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKP
DSNQLILEHAGTFFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK
DGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFL
FEISLVFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVL
KASNIETKQEWIKNIREVIQERIIHLKGALKEPLQLPKTPAKQRNNSKRDGVEDIDSQGD
GSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPS
ERPGWCLVRTTERSPPLEGLVPSSALCISHSRSSVEMDCFFPLVKDAYSHSSSENGGKSE
SVANLQAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSF
DLGSPKPGDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLL
AARQASTEVPTAADLVNAIEKLVKNKLSLEGSSYRGSLKDPAGCLNEGMAPPTPPKNPEE
EQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGNIH
QIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYIVAEYDAYFE
EVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLVPKR
CNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFLFEQIVIFSELL
RKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFALMNRETSERVVLQAANADIQQAWVQD
INQVLETQRDFLNALQSPIEYQRKERSTAVMRSQPARLPQASPRPYSSVPAGSEKPPKGS
SYNPPLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEI
CVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLTKATAAESSDGSIKKS
CSWHTLRMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEI
LNPNFIQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSAT
YTVSSCDSGEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQER
SCTSVILRWLPPSSTGNCTISGYTVEYREEGSQIWQQSVASTLDTYLVIEDLSPGCPYQF
RVSASNPWGISLPSEPSEFVRLPEYDAAADGATISWKENFDSAYTELNEIGRGRFSIVKK
CIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPTSYILILELM
DDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPVPRV
KLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF
LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQP
HNGSYSKIPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQGT
NT seq 8961 nt   +upstreamnt  +downstreamnt
atgacggaccgcttctgggaccagtggtatctctggtatctccgcttgctccggctgctg
gatcgagggtcttttcggaatgatggtttgaaagcttctgatgtccttcctatcctaaag
gaaaaggtggccttcgtgtctgggggtcgtgataagcgaggcggacccatcctgaccttc
cctgctcgcagcaatcatgacagaataagacaggaagacctgcggaaactcgtgacgtat
ttggccagcgtgccaagtgaggacgtgtgcaaacgtggcttcactgtcatcatcgacatg
cggggctccaagtgggacctcatcaagcccctcctcaaaacgctgcaggaagcctttcca
gctgagatccatgtggccctcatcattaaacccgacaacttctggcagaaacagaagacc
aactttggcagctccaaattcatctttgagacgagcatggtatctgtggagggcctcaca
aagctggtggacccctcccagctgacggaggagtttgatggctccctggactacaaccat
gaggagtggatcgaactgcggctctccctggaggagttcttcaacagcgccgtgcacctg
ctctcgcgcctcgaggacctccaggagatgctagcccggaaggagtttcctgtggatgtg
gagggctctcggcggctcattgacgaacacacacagctcaagaaaaaggtgctgaaggcc
cctgtggaggagctggaccgggaggggcagcggctgctgcagtgcatccgctgcagcgac
ggcttctcaggacgcaactgcatcccgggcagtgctgacttccagagcctggtgcccaag
atcaccagtctcctggacaagctgcactccacccggcagcacctgcaccagatgtggcat
gtgcgcaagctcaagctggaccagtgctttcagctgcggctcttcgagcaggatgctgag
aagatgtttgactggataagccacaacaaggagttattcctccagagccacacggagatc
ggagtcagctaccagtacgcccttgacctccagacgcagcacaatcactttgccatgaac
tccatgaatgcctatgtcaacatcaaccgcatcatgtccgtggcttcccgcctctctgag
gccggtcattatgcctcacaacaaatcaagcagatctccacccagctggaccaggagtgg
aagagcttcgctgctgccctggatgaacgcagcaccatcctcgccatgtctgctgtgttc
caccagaaggctgagcagttcctgtcgggagtggatgcctggtgcaagatgtgcagtgaa
ggtggtctgccatccgagatgcaagacctagagctggcaatccaccaccaccagaccttg
tatgagcaggtgacccaagcctacacagaggtcagccaggatggcaaagcactacttgat
gtgctgcagcggcccctgagccctgggaactccgaatccctcacggccacagccaactac
tccaaggcagtgcaccaggtgctggacgtggtgcatgaggtgttacatcaccagcgacgg
ctggagagcatctggcagcaccgcaaggtgcggctccaccagcggctgcagctctgcgtc
ttccagcaggatgtacagcaggtgttggactggattgaaaaccatggtgaggcctttctc
agcaaacacactggagttgggaagtccctacatcgagcccgggccctgcagaagaggcat
gatgactttgaagaggtggctcagaatacgtacaccaatgcggacaagctcctagaagca
gcagagcagttggctcagacgggggaatgtgaccccgaggagatctacaaggcagctcga
cacctggaggtgcgcatccaagacttcgtgcgcagggtggagcagcggaagcttctcctg
gacatgtctgtttccttccacacacacaccaaagagttgtggacatggatggaagacctt
cagaaggagatgttggaggatgtctgtgcagattctgtggatgcagtccaggaactgatc
aagcagttccagcagcagcagaccgccactctagatgccacactcaatgtcatcaaggaa
ggcgaagaccttatccagcagctcaggtcagcgcctccctccctcggggagcccagcgag
gccagggactcggctgtgtccaacaacaaaacaccccacagcagctccatcagccacatc
gagtcggtcctgcagcagcttgatgatgcccaggtgcagatggaggagctgttccacgag
cggaagatcaagctggacatcttcctgcaactgcgcatctttgagcagtacaccatcgag
gtgacagcagagctagacgcctggaatgaagacttgcttcggcagatgaatgacttcaac
acagaggacctaaccctggcagaacagcggctgcagcgccacacagaacggaagctagcc
atgaacaacatgacctttgaggttatccagcagggacaggatctgcaccagtacatcacg
gaggtccaggcatcaggaattgagttgatctgtgaaaaagacattgatctggcagcccag
gtgcaagagttattggaatttctccatgagaagcagcatgaattggagctcaatgcagag
cagactcataagcggctagagcagtgcctccaattacgtcacctccaggctgaagtcaaa
caggttctgggatggatccgcaatggagagtcaatgctcaacgccagcctggtcaatgcc
agctctttgtcggaagcagagcagctgcagcgggagcacgagcagttccaactggccatc
gagtccctctttcatgccacttccttgcagaagacgcaccagagtgccctgcaggtacag
cagaaagccgaggtgctgctccaggccggccactacgatgccgatgccatccgggaatgt
gctgagaaggtggccctccactggcagcagctcatgctgaagatggaagaccggctaaaa
ttggtcaatgcctctgtggccttttacaaaacttctgaacaggtgtgtagtgtcctggag
agcttagagcaagaataccggagagatgaggactggtgtggtggacgagataagctgggg
ccagcagcagagatcgaccatgtcattcccctcatcagcaaacatttggaacaaaaggag
gcctttcttaaggcctgcaccctggctcggcggaatgctgaggtgtttctcaagtacatc
cacaggaacaacgtcagcatgcccagtgtcgccagccacactcggggacccgagcaacaa
gtgaaagccatcctgagtgagctcctgcagagggagaatcgcgtgctgcatttctggacc
ttgaagaagcggcggttagaccaatgccagcaatatgtggtgttcgagcgcagcgctaag
caggcgcttgactggatccaagaaacaggtgaattttacctctcaacacatacctccact
ggagagaccacagaggagactcaggaactgctgaaagaatatggggaattcagggtgcct
gccaagcaaacaaaggagaaggtgaagcttctgattcagctggccgatagctttgtggaa
aaaggccacattcatgccacggagataaggaaatgggtgaccacggtggacaagcactac
agagatttctccctgaggatgggaaagtaccgatactcactggagaaagccctaggagtc
aacacagaggataataaggacctggagctggatattatcccagcaagcctttcggatcgg
gaggtcaagctgcgggacgccaaccacgaagtcaatgaagagaagcggaagtcagcccgg
aagaaagaatttattatggctgaactactccagacagagaaggcttatgtaagggatttg
catgagtgcttagagacctacctgtgggaaatgaccagtggtgtggaggagatcccccct
gggatcctcaataaagagcatatcatctttggcaacatccaagagatctacgatttccat
aacaacatcttcctcaaagagctggagaagtacgagcaactgcctgaggatgtgggacac
tgctttgttacctgggcagacaaatttcagatgtatgtcacctactgtaaaaacaagcct
gattccaaccagcttatcctggagcatgcgggcaccttctttgatgagatacaacagcgg
catggtctggccaactccatctcttcctacctaattaagcctgtccaaaggatcaccaaa
tatcaactgctcctgaaggaacttttaacttgctgtgaagaagggaaaggggagctcaag
gatggcctggaggtgatgctcagtgtcccaaagaaagccaatgatgccatgcatgtcagc
atgctggaagggttcgacgagaacctggatgtgcagggggagttgattctccaggatgcc
tttcaagtgtgggacccgaagtcgctgatccggaaggggcgggagcggcacttgttcctc
tttgagatctccttggtttttagcaaggagatcaaagattcttcaggacacacgaaatat
gtttacaagaacaagctactgacctcagagctgggtgtgaccgagcacgtggagggcgat
ccctgcaaattcgccttgtggtctgggcgcaccccatcctcagacaataaaacagtgctg
aaagcctccaacattgaaaccaagcaggagtggatcaagaacattcgagaagtgattcaa
gaaaggatcattcacctgaaaggagctttaaaggagccacttcagctccccaaaacacca
gccaaacagaggaacaatagtaagagggatggagtggaggatattgacagccagggggat
gggagcagccaaccagacaccatctccattgcttctaggacctctcagaacacagtggac
agtgacaagctctctggtggatgtgagctgacagtggtcctccaggacttcagtgcgggc
cacagcagtgagctgaccatccaggtggggcagacggtagagctgctggagcggcccagc
gagcggcctggttggtgtctggtccgtaccaccgaacggagcccgcccttggagggtctg
gtccccagcagcgccctgtgcatctcacactcccgaagcagcgtggagatggactgcttc
ttccccttggtgaaagatgcatactctcattcctcaagcgagaatggaggcaagtccgag
tccgtggccaacctgcaggcccagccctccctgaactccatccacagttccccgggtccc
aagcgctccaccaacactcttaagaagtggctgacgagtcctgtgcgtcggcttaacagc
gggaaggcagatggaaacatcaaaaagcagaagaaagttcgcgatggtcggaagagcttt
gacctgggatctcccaagcctggggatgaaacaacccctcagggagacagcgctgatgag
aagagcaagaaaggttggggtgaagatgagccggatgaagagtcacacacacccctccca
ccacctatgaagatttttgacaacgaccctacacaggatgaaatgtcctcctctttgcta
gcagcccggcaggcttccactgaagtacctactgctgcagaccttgtcaatgcaatagaa
aagttggtcaaaaacaagctgagtctagaaggaagctcataccgggggagcttgaaagac
cctgcaggctgcctgaatgaggggatggccccacccacacctcctaaaaacccagaagaa
gaacagaaagccaaggccctgagaggcaggatgtttgtcctgaatgagctggtacagaca
gagaaagactatgtcaaggatctgggcattgtggtggagggcttcatgaagagaatagaa
gaaaagggtgtccctgaggatatgcgaggaaaggacaaaatcgtgtttggaaatattcat
cagatttatgactggcataaggattttttcctggcggaactggaaaagtgtatccaggag
caagacagattggcacagctctttattaagcacgagcggaagctgcacatctacgtgtgg
tattgtcagaataagccgcgctcagagtacatcgttgctgagtatgacgcctactttgag
gaggtaaaacaggagataaatcagaggctgacactgagtgacttcctcatcaagcccatt
cagagaataacaaaataccagttgctcctcaaggacttcctgagatacagtgagaaggct
ggtttggagtgttcagatattgagaaagcagtggagttaatgtgccttgttcccaaacgc
tgcaatgacatgatgaatctaggacgtctgcagggctttgagggcactctgactgctcag
gggaagctgctgcagcaggacacattctatgtgatcgagctggatgcaggcatgcagtcc
cggaccaaagagaggcgcgtgttcctcttcgagcagattgtcatcttcagtgaactgctc
aggaagggatccctcacccctggctacatgttcaaaaggagcatcaagatgaattacttg
gtcctggaggagaatgtggacaatgatccctgcaagtttgcactcatgaacagagagact
tctgagagggttgttctgcaagccgccaacgctgacatccagcaggcctgggtgcaggac
atcaatcaagtcttagaaacacagcgagactttttgaatgcactgcaatcgcccattgag
tatcaacggaaagaaaggagcacagctgtgatgaggtctcaacctgccaggcttccccaa
gccagccccaggccctactcctctgttcctgcgggctcagagaagcccccaaagggctcc
agctataacccacctctgcctcccctgaagatatctacctccaatggcagtccagggttt
gaataccaccagcctggggacaagttcgaagccagcaagcagaacgacctgggaggctgc
aatgggacctcgtccatggccgtgatcaaagattactatgcactgaaggagaatgaaatc
tgtgtgagccaaggtgaggtggtccaggtcctcgccgtcaaccagcagaacatgtgtctg
gtgtaccagcctgccagcgaccattcccccgccgccgagggctgggtcccaggcagcatc
ctggcgcccctcaccaaagccacagcagcagaaagtagtgacgggagcatcaagaagtca
tgttcatggcatactctacgcatgagaaagcgggcggaagtggagaacacgggtaaaaat
gaagccacagggcctcgtaaacccaaggatattctgggcaacaaagtctctgttaaagag
acgaacagttccgaggaatcagagtgtgatgatcttgaccctaatactagcatggagatc
ttaaatccaaatttcatccaagaagtggccccagaattccttgtgcccttggtggatgtg
acctgcttgcttggggacacagtgatactgcagtgcaaagtctgtgggcggccaaagccc
accatcacttggaagggtccagaccagaacatccttgacactgataacagctcagccaca
tacacggtctcctcttgtgattctggagaaatcaccctgaagatctgtaatctgatgccc
caagacagtgggatttatacctgcatagcaacaaatgaccacgggaccacatcaacgtct
gcaacagtcaaagtgcaaggtgttccagcagcccctaaccgccccattgcccaggagaga
agctgcacctccgtgattctccgctggctgcccccctccagcacaggaaactgcactatt
tctggttacactgtggagtacagagaggaaggttctcagatctggcagcagtcagtggct
tcgaccttggacacttacctcgtcatcgaagaccttagtcccgggtgtccttatcagttc
agagtcagtgccagtaacccctggggaatcagccttcccagcgagccctcggagtttgtg
cgacttccagaatatgatgctgctgctgatggtgccaccatttcttggaaggaaaatttt
gactcagcttacactgagctgaatgaaattggaagaggccgtttctctatagtaaagaaa
tgcattcacaaagctacccgcaaagatgtggctgtgaaatttgttagcaaaaaaatgaag
aagaaagaacaggctgcccacgaggctgccctgcttcagcacctacagcacccccagtac
atcactctccatgacacctatgagtcccccacatcctacatcctgatcttggaactgatg
gatgatggccggctcttagactaccttatgaatcatgatgaactgatggaggaaaaagta
gctttctatatccgagacatcatggaggctctgcagtaccttcacaactgcagggttgca
catttggacataaagcctgaaaacctgctcattgacctacggattccagtgcctcgagtg
aagctcattgacttggaggatgctgtccagatctcgggtcacttccacattcaccacctg
ctggggaaccctgagtttgctgccccagaagtcattcaaggcatccccgtctccctgggg
acagacatctggagcatcggggttctgacatatgtcatgctgagtggggtctcccccttc
ttggatgagagcaaagaggagacatgtatcaacgtatgcagggtggatttcagcttcccc
catgaatacttctgtggtgtgagcaatgctgccagagatttcatcaatgtgatcttacag
gaagattttcggaggcggcccacagcagccacatgcttgcagcatccatggctgcagccc
cataatggcagctactctaagatccccctggacacctcccgcctagcatgcttcatagaa
cgtcgcaagcaccagaatgatgtgcggcctattcccaatgtcaagagctacattgtcaac
cgggtgaaccaagggacgtag

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Ontology (5)   
   KEGG BRITE (5)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (73)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (71)   
DNA sequence (128)   
   RefSeq(nuc) (74)   
   GenBank (27)   
   EMBL (27)   
3D Structure (12)   
   PDB (12)   
Protein domain (24)   
   Pfam (24)   
All databases (280)   

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