KEGG   Homo sapiens (human): 9025
Entry
9025              CDS       T01001                                 
Symbol
RNF8, hRNF8
Name
(RefSeq) ring finger protein 8
  KO
K10667  E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
Organism
hsa  Homo sapiens (human)
Network
nt06506  Double-strand break repair
  Element
N01439  Double-strand break signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9025 (RNF8)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9025 (RNF8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     9025 (RNF8)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    9025 (RNF8)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   Other DSBR factors
    Ubiquitin ligases
     9025 (RNF8)
SSDB
Motif
Pfam: FHA zf-C3HC4_3 zf-C3HC4 zf-C3HC4_2 zf-RING_2 zf-RING_UBOX zf-C3HC4_4 zf-rbx1 zf-RING_5 Prok-RING_4 Yop-YscD_cpl zf-ANAPC11 zf-RING_6 zf-RING_10 Peptidase_S76 DUF6594
Other DBs
NCBI-GeneID: 9025
NCBI-ProteinID: NP_003949
OMIM: 611685
HGNC: 10071
Ensembl: ENSG00000112130
UniProt: O76064
Structure
Position
6:37353983..37394734
AA seq 485 aa
MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS
RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY
EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS
CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS
ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC
AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD
FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAH
SFCSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCINKMVNNLSSEVKERRIVLIRERK
AKRLF
NT seq 1458 nt   +upstreamnt  +downstreamnt
atgggggagcccggcttcttcgtcacaggagaccgcgccggtggccggagctggtgcctg
cggcgggtggggatgagcgccgggtggctgctgctggaagatgggtgcgaggtgactgta
ggacgaggatttggtgtcacataccaactggtatcaaaaatctgccccctgatgatttct
cgaaaccactgtgttttgaagcagaatcctgagggccaatggacaattatggacaacaag
agtctaaatggtgtttggctgaacagagcgcgtctggaacctttaagggtctattccatt
catcagggagactacatccaacttggagtgcctctggaaaataaggagaatgcggagtat
gaatatgaagttactgaagaagactgggagacaatatatccttgtctttccccaaagaat
gaccaaatgatagaaaaaaataaggaattgagaactaaaaggaaattcagtttggatgaa
ttagcaggtcctggagctgaaggcccctcaaatttgaaatccaaaataaataaagtgtct
tgtgaatctggtcagccagtgaaatcacaggggaaaggtgaagtggccagtacaccctct
gacaatttggatcctaagttgactgcccttgagccaagtaagaccacaggggctcccatt
taccctggcttccccaaagtcacagaggttcatcatgagcagaaagcctcaaactcttca
gcatctcagagaagcttacagatgtttaaggtgaccatgtccaggattctgaggctcaaa
atacagatgcaggaaaaacatgaagccgttatgaatgtgaaaaagcagacccaaaagggg
aactcaaagaaagttgtgcaaatggagcaggaacttcaggacttacagtcccagctgtgt
gcagagcaggctcagcagcaggcaagagtggagcaactagagaagactttccaggaagag
gaacagcatcttcagggtttggagatagcccaaggagaaaaggacctgaagcaacagctg
gcccaggctctgcaggagcattgggctctaatggaagagctaaatcgcagcaagaaggac
tttgaagcaatcattcaagccaagaacaaagaattagagcagaccaaggaagagaaggag
aagatgcaagcacagaaggaagaagttcttagccacatgaatgatgtgctagagaatgag
ctccaatgtattatttgttcagaatacttcattgaggctgtcaccttgaactgtgcccac
agtttctgctcctactgtatcaatgaatggatgaagcggaagatagaatgccccatttgt
cggaaggacattaagtccaaaacgtactctttggttctggacaattgcattaataagatg
gtaaataatctgagctcagaagtgaaagaacgacgaattgttctcattagggaacgaaaa
gcaaagagattgttctga

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Ontology (4)   
   KEGG BRITE (4)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (33)   
   RefSeq(nuc) (3)   
   GenBank (15)   
   EMBL (15)   
3D Structure (5)   
   PDB (5)   
Protein domain (16)   
   Pfam (16)   
All databases (93)   

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