KEGG   Homo sapiens (human): 90268
Entry
90268             CDS       T01001                                 
Symbol
OTULIN, AIPDS, FAM105B, GUM, IMD107
Name
(RefSeq) OTU deubiquitinase with linear linkage specificity
  KO
K18343  ubiquitin thioesterase otulin [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Network
nt06516  TNF signaling
  Element
N01546  Regulation of TNF-NFKB signaling pathway, OTULIN/TNFAIP3-mediated deubiquitination
Disease
H02414  Autoinflammation, panniculitis, and dermatosis syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    90268 (OTULIN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     90268 (OTULIN)
Ubiquitin system [BR:hsa04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   OTU
    90268 (OTULIN)
SSDB
Motif
Pfam: Peptidase_C101 Peptidase_C65 SRCR_2
Other DBs
NCBI-GeneID: 90268
NCBI-ProteinID: NP_612357
OMIM: 615712
HGNC: 25118
Ensembl: ENSG00000154124
UniProt: Q96BN8
Structure
Position
5:14664718..14716525
AA seq 352 aa
MSRGTMPQPEAWPGASCAETPAREAAATARDGGKAAASGQPRPEMQCPAEHEEDMYRAAD
EIEKEKELLIHERGASEPRLSVAPEMDIMDYCKKEWRGNTQKATCMKMGYEEVSQKFTSI
RRVRGDNYCALRATLFQAMSQAVGLPPWLQDPELMLLPEKLISKYNWIKQWKLGLKFDGK
NEDLVDKIKESLTLLRKKWAGLAEMRTAEARQIACDELFTNEAEEYSLYEAVKFLMLNRA
IELYNDKEKGKEVPFFSVLLFARDTSNDPGQLLRNHLNQVGHTGGLEQVEMFLLAYAVRH
TIQVYRLSKYNTEEFITVYPTDPPKDWPVVTLIAEDDRHYNIPVRVCEETSL
NT seq 1059 nt   +upstreamnt  +downstreamnt
atgagtcgggggactatgccccagcccgaagcgtggccaggcgcgagctgcgccgagacg
ccggcgcgggaggcggcggccacggcgcgggacggcgggaaggcggcggccagcgggcag
ccgcggcccgagatgcagtgcccggccgagcatgaggaggacatgtaccgtgctgcagat
gaaatagaaaaggagaaagaattgcttatacatgaaagaggggcatcagaaccgagatta
agcgtagctcctgaaatggatatcatggactactgcaaaaaagaatggagaggaaataca
cagaaagcaacgtgtatgaaaatgggctatgaagaggtttctcagaagttcacctccata
cggcgagtccgtggtgataattactgtgcactgagggccacgctgttccaggccatgagc
caggctgtggggctgccgccctggctgcaggacccggagctcatgctgttaccagaaaaa
ctcataagcaaatacaactggatcaagcaatggaaacttggactgaaatttgatgggaag
aatgaggacctggttgataaaattaaagagtcccttactctgctgaggaagaagtgggca
ggcttggctgaaatgagaactgctgaagcaagacagatagcttgtgatgaactattcaca
aatgaggcggaggaatatagcctctatgaagctgtaaaatttctaatgctaaacagagcc
attgaactatataatgataaagagaaaggaaaggaagtaccatttttctctgtgcttctg
tttgctcgggacacatcaaatgacccaggacagcttctgaggaaccacctcaaccaggtg
ggacacactggtggtcttgaacaggttgaaatgttccttcttgcctatgctgtgcgccac
accatccaggtgtaccggctctccaagtacaacacggaagaattcatcacagtctacccc
accgacccacccaaggactggccagtggtaacgctcattgctgaggacgatcggcactat
aacatccccgtcagagtgtgtgaggagaccagtctatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (24)   
   RefSeq(nuc) (10)   
   GenBank (7)   
   EMBL (7)   
3D Structure (11)   
   PDB (11)   
Protein domain (3)   
   Pfam (3)   
All databases (80)   

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