KEGG   Homo sapiens (human): 9054
Entry
9054              CDS       T01001                                 
Symbol
NFS1, COXPD52, HUSSY-08, IscS, NIFS
Name
(RefSeq) NFS1 cysteine desulfurase
  KO
K04487  cysteine desulfurase [EC:2.8.1.7]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00730  Thiamine metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04122  Sulfur relay system
Disease
H00891  Combined oxidative phosphorylation deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    9054 (NFS1)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04122 Sulfur relay system
    9054 (NFS1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    9054 (NFS1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    9054 (NFS1)
  09183 Protein families: signaling and cellular processes
   02048 Prokaryotic defense system [BR:hsa02048]
    9054 (NFS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.1  Sulfurtransferases
    2.8.1.7  cysteine desulfurase
     9054 (NFS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA modification factors
   Thiolation factors
    9054 (NFS1)
 Prokaryotic type
    9054 (NFS1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Proteins involved in Fe-S cluster biogenesis
    9054 (NFS1)
Prokaryotic defense system [BR:hsa02048]
 DNA phosphothiolation system
  Sulfur modification proteins
   9054 (NFS1)
SSDB
Motif
Pfam: Aminotran_5 Beta_elim_lyase DegT_DnrJ_EryC1 Pyridoxal_deC
Other DBs
NCBI-GeneID: 9054
NCBI-ProteinID: NP_066923
OMIM: 603485
HGNC: 15910
Ensembl: ENSG00000244005
UniProt: Q9Y697 Q53FP3
Structure
Position
20:complement(35668052..35699352)
AA seq 457 aa
MLLRAAWRRAAVAVTAAPGPKPAAPTRGLRLRVGDRAPQSAVPADTAAAPEVGPVLRPLY
MDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPRE
IIFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQK
SGIIDLKELEAAIQPDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKI
PLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPL
VVGLGAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCINLSFAY
VEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSSIRFGIGRFTTEEEVD
YTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWTQH
NT seq 1374 nt   +upstreamnt  +downstreamnt
atgctgctccgagccgcttggaggcgggcggcagtggcggtgacagcggctccagggccg
aagcccgcggcgcccactcgggggctgcgcctgcgcgttggagaccgtgctcctcagtct
gcggttcccgcagatacagccgctgccccggaggtggggccagtgctgcgacctctctat
atggatgtgcaagctacaactcctctggacccccgggtgcttgatgccatgctcccttac
ctaatcaactactatgggaacccacactcccggacacatgcttatggctgggagagtgag
gcagccatggaacgtgctcgtcagcaagtagcatctctgattggagctgatcctcgtgag
atcatttttactagtggtgctactgaatccaacaacatagcaattaagggggtggcccga
ttctacaggtcacggaaaaagcacttgatcaccacccagacagaacacaaatgtgtcttg
gactcctgccgttcactggaagctgagggctttcaggtcacctacctcccagtgcagaag
agtgggatcattgacctaaaggaactagaggctgctatccagccagatactagcctggtg
tcagtcatgactgtgaacaatgagattggagtgaagcagcctattgcagaaatagggcgg
atttgcagttccagaaaggtatatttccatactgatgcagcccaggctgttggaaaaatc
ccacttgatgtcaatgacatgaaaattgatctcatgagcattagtggtcacaaaatctac
ggtcccaaaggggttggtgccatctacatccgtcgccggccccgtgtgcgtgtggaggcc
ctgcagagtggaggggggcaggagcggggtatgcggtctgggacagtgcccacaccctta
gtggtggggctgggggctgcgtgtgaggtggcacagcaagagatggagtatgaccacaag
cgaatctcaaagttgtcagagcggctgatacagaatataatgaagagccttccagatgtg
gtgatgaatggggaccctaagcaccattatcccggctgtatcaacctctcctttgcatat
gtggaaggggaaagtctgctgatggcactgaaggacgttgccttatcctcagggagtgcc
tgcacctctgcatccctggagccctcttatgtgcttagagcaattggcactgatgaggat
ttagcgcactcttctatcaggtttggaattggccgcttcactacagaggaggaagtggac
tacacagtggagaaatgcattcagcatgtgaagcgtcttcgagaaatgagccctctctgg
gagatggttcaggatggcattgacctcaagagcatcaagtggacccaacactag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (36)   
   RefSeq(nuc) (4)   
   GenBank (16)   
   EMBL (16)   
3D Structure (11)   
   PDB (11)   
Protein domain (4)   
   Pfam (4)   
All databases (95)   

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