KEGG   Homo sapiens (human): 91801
Entry
91801             CDS       T01001                                 
Symbol
ALKBH8, ABH8, MRT71, TRM9, TRMT9, TRMT9A
Name
(RefSeq) alkB homolog 8, tRNA methyltransferase
  KO
K10770  alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229]
Organism
hsa  Homo sapiens (human)
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    91801 (ALKBH8)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.229  tRNA (carboxymethyluridine34-5-O)-methyltransferase
     91801 (ALKBH8)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA modification factors
   Methyltransferases
    91801 (ALKBH8)
SSDB
Motif
Pfam: 2OG-FeII_Oxy_2 Methyltransf_11 ALKBH8_N Methyltransf_25 Methyltransf_12 Methyltransf_31 Methyltransf_23 Methyltransf_8 RRM_1 2OG-FeII_Oxy Ubie_methyltran MetW
Other DBs
NCBI-GeneID: 91801
NCBI-ProteinID: NP_001287939
OMIM: 613306
HGNC: 25189
Ensembl: ENSG00000137760
UniProt: Q96BT7
Structure
Position
11:complement(107502727..107565735)
AA seq 664 aa
MDSNHQSNYKLSKTEKKFLRKQIKAKHTLLRHEGIETVSYATQSLVVANGGLGNGVSRNQ
LLPVLEKCGLVDALLMPPNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFV
EKVQWKELRPQALPPGLMVVEEIISSEEEKMLLESVDWTEDTDNQNSQKSLKHRRVKHFG
YEFHYENNNVDKDKPLSGGLPDICESFLEKWLRKGYIKHKPDQMTINQYEPGQGIPAHID
THSAFEDEIVSLSLGSEIVMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFD
TVQASESLKSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKETPPSF
PESDKEASRLEQEYVHQVYEEIAGHFSSTRHTPWPHIVEFLKALPSGSIVADIGCGNGKY
LGINKELYMIGCDRSQNLVDICRERQFQAFVCDALAVPVRSGSCDACISIAVIHHFATAE
RRVAALQEIVRLLRPGGKALIYVWAMEQEYNKQKSKYLRGNRNSQGKKEEMNSDTSVQRS
LVEQMRDMGSRDSASSVPRINDSQEGGCNSRQVSNSKLPVHVNRTSFYSQDVLVPWHLKG
NPDKGKPVEPFGPIGSQDPSPVFHRYYHVFREGELEGACRTVSDVRILQSYYDQGNWCVI
LQKA
NT seq 1995 nt   +upstreamnt  +downstreamnt
atggacagcaaccatcaaagtaattacaaactcagtaaaactgagaagaagttcttaagg
aaacagattaaagccaagcatactttgctgagacatgaaggcattgagacagtatcctat
gccactcagagcctggttgttgccaatggtggtttgggtaatggtgtgagtcggaaccag
ctgctcccggttttagagaaatgtggactggtggatgctctcttaatgccacctaacaag
ccgtactcatttgcaagatacagaactacagaagaatctaagagagcctatgttaccctc
aatggaaaagaagtagtggatgatttaggacaaaagatcactctgtatttgaattttgtg
gaaaaagtgcagtggaaggagttgaggcctcaagccttaccaccaggactcatggtagta
gaagaaataatttcttctgaggaggagaaaatgcttttggaaagtgttgattggacagaa
gatacagacaatcaaaactctcaaaaatccttaaaacacagaagagtaaagcattttggt
tatgagttccactatgagaacaacaatgtagataaagataagccattatctgggggtctt
cctgacatttgtgaaagctttttggagaaatggttgaggaaaggttacattaaacataaa
cctgatcaaatgaccataaatcagtatgaacctgggcaaggaattcccgctcatattgat
acacattccgcttttgaggatgagatcgtttctctcagtttggggtcagagattgtcatg
gattttaagcacccagatggcattgcagtgccagttatgttgcctcgtcggagtttgctg
gtgatgacaggagaatctagatacctttggacccatggaatcacgtgcagaaaatttgat
actgttcaagcatctgagagtcttaaaagtggaattatcaccagtgatgttggagactta
actttaagcaagaggggactacgaacatcatttacatttaggaaagtgaggcaaacacct
tgtaactgtagttacccgttggtctgtgatagccagaggaaagagactcccccctcattt
ccagagagtgataaagaagcctcacggctggagcaagagtacgtccatcaggtttatgaa
gagattgctgggcacttcagcagcacaagacataccccttggccgcacattgtggagttt
ttgaaggctttgccaagtggttcaatagtggctgatattggatgtggtaatggaaagtat
cttggcatcaataaggagttatatatgattggttgtgatcgtagccaaaaccttgtggac
atttgtagagagaggcaatttcaggcttttgtctgtgatgcattggcagtaccagtccgc
agtgggtcttgtgatgcctgcatctccattgctgttattcatcattttgcaacagcagag
cgtagagtggcagctctccaagaaattgttcgactcctgagaccaggtgggaaggcactc
atttatgtctgggcaatggaacaagaatataataagcagaagtccaagtatcttagagga
aacagaaatagccaaggaaagaaagaggagatgaacagtgatacctcagtgcagaggtca
cttgtggagcaaatgcgtgacatgggcagtcgagactcggcatcttctgtcccccgcatt
aatgactctcaggaaggaggatgtaattcaaggcaagtttctaattccaagctgcctgtt
catgttaacaggacttctttttattctcaagatgtactggttccctggcaccttaaggga
aatcctgataaaggcaaacctgttgagccatttggtcccataggatcccaggacccaagt
cctgtgtttcatcgttactaccatgtgttccgtgagggagaactggaaggtgcctgcagg
actgtgagtgatgtcagaattctgcaaagctactacgatcaaggaaactggtgtgtgatt
cttcaaaaggcctga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (31)   
   RefSeq(nuc) (15)   
   GenBank (8)   
   EMBL (8)   
3D Structure (3)   
   PDB (3)   
Protein domain (12)   
   Pfam (12)   
All databases (77)   

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