KEGG   Homo sapiens (human): 920
Entry
920               CDS       T01001                                 
Symbol
CD4, CD4mut, IMD79, Leu-3, OKT4D, T4
Name
(RefSeq) CD4 molecule
  KO
K06454  T-cell surface glycoprotein CD4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa03260  Virion - Human immunodeficiency virus
hsa04060  Cytokine-cytokine receptor interaction
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05135  Yersinia infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340  Primary immunodeficiency
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H02526  Disorders of adaptive immunity
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Cedelizumab: D03420
Ibalizumab: D09575<US>
Lifileucel: D12833<US>
Priliximab: D05610
Zanolimumab: D06356
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    920 (CD4)
   03260 Virion - Human immunodeficiency virus
    920 (CD4)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    920 (CD4)
   04514 Cell adhesion molecules
    920 (CD4)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    920 (CD4)
   04612 Antigen processing and presentation
    920 (CD4)
   04660 T cell receptor signaling pathway
    920 (CD4)
   04658 Th1 and Th2 cell differentiation
    920 (CD4)
   04659 Th17 cell differentiation
    920 (CD4)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    920 (CD4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    920 (CD4)
   05170 Human immunodeficiency virus 1 infection
    920 (CD4)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    920 (CD4)
  09163 Immune disease
   05340 Primary immunodeficiency
    920 (CD4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    920 (CD4)
CD molecules [BR:hsa04090]
 Proteins
  920 (CD4)
SSDB
Motif
Pfam: CD4-extracel C2-set ig Tcell_CD4_C V-set I-set Ig_3 Ig_2 Receptor_2B4
Other DBs
NCBI-GeneID: 920
NCBI-ProteinID: NP_000607
OMIM: 186940
HGNC: 1678
Ensembl: ENSG00000010610
UniProt: P01730 B4DT49 A0A4Y5UGE4
Structure
Position
12:6789528..6820799
AA seq 458 aa
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIK
ILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQL
LVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSG
TWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWW
QAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLA
LEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWV
LNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCV
RCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
NT seq 1377 nt   +upstreamnt  +downstreamnt
atgaaccggggagtcccttttaggcacttgcttctggtgctgcaactggcgctcctccca
gcagccactcagggaaagaaagtggtgctgggcaaaaaaggggatacagtggaactgacc
tgtacagcttcccagaagaagagcatacaattccactggaaaaactccaaccagataaag
attctgggaaatcagggctccttcttaactaaaggtccatccaagctgaatgatcgcgct
gactcaagaagaagcctttgggaccaaggaaactttcccctgatcatcaagaatcttaag
atagaagactcagatacttacatctgtgaagtggaggaccagaaggaggaggtgcaattg
ctagtgttcggattgactgccaactctgacacccacctgcttcaggggcagagcctgacc
ctgaccttggagagcccccctggtagtagcccctcagtgcaatgtaggagtccaaggggt
aaaaacatacagggggggaagaccctctccgtgtctcagctggagctccaggatagtggc
acctggacatgcactgtcttgcagaaccagaagaaggtggagttcaaaatagacatcgtg
gtgctagctttccagaaggcctccagcatagtctataagaaagagggggaacaggtggag
ttctccttcccactcgcctttacagttgaaaagctgacgggcagtggcgagctgtggtgg
caggcggagagggcttcctcctccaagtcttggatcacctttgacctgaagaacaaggaa
gtgtctgtaaaacgggttacccaggaccctaagctccagatgggcaagaagctcccgctc
cacctcaccctgccccaggccttgcctcagtatgctggctctggaaacctcaccctggcc
cttgaagcgaaaacaggaaagttgcatcaggaagtgaacctggtggtgatgagagccact
cagctccagaaaaatttgacctgtgaggtgtggggacccacctcccctaagctgatgctg
agtttgaaactggagaacaaggaggcaaaggtctcgaagcgggagaaggcggtgtgggtg
ctgaaccctgaggcggggatgtggcagtgtctgctgagtgactcgggacaggtcctgctg
gaatccaacatcaaggttctgcccacatggtccaccccggtgcagccaatggccctgatt
gtgctggggggcgtcgccggcctcctgcttttcattgggctaggcatcttcttctgtgtc
aggtgccggcaccgaaggcgccaagcagagcggatgtctcagatcaagagactcctcagt
gagaagaagacctgccagtgtcctcaccggtttcagaagacatgtagccccatttga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Network (3)   
   KEGG NETWORK (3)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Drug (6)   
   KEGG DRUG (6)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (13)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (60)   
   RefSeq(nuc) (10)   
   GenBank (25)   
   EMBL (25)   
3D Structure (77)   
   PDB (77)   
Protein domain (9)   
   Pfam (9)   
All databases (208)   

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