| Entry |
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| Symbol |
AURKB, AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2
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| Name |
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| KO |
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| Organism |
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| Pathway |
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| Network |
nt06512 Chromosome cohesion and segregation nt06515 Regulation of kinetochore-microtubule interactions |
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| Element |
| N01485 | Cohesin dissociation in prophase |
| N01499 | Modifying of condensin II subunits |
| N01500 | Modifying of condensin I subunits |
| N01526 | Organization of the outer kinetochore |
| N01529 | Recruitment and formation of the MCC |
| N01531 | CENPE interaction with NDC80 complex |
| N01536 | Dephosphorylation of kinetochore |
| N01561 | Microtubule depolymerization |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09126 Chromosome
03083 Polycomb repressive complex
9212 (AURKB)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
9212 (AURKB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
9212 (AURKB)
01009 Protein phosphatases and associated proteins [BR:hsa01009]
9212 (AURKB)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:hsa03036]
9212 (AURKB)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
9212 (AURKB)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: AGC group
AUR family [OT]
9212 (AURKB)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
PP1-interacting proteins (PIPs)
9212 (AURKB)
Chromosome and associated proteins [BR:hsa03036]
Eukaryotic type
Centromeric chromatin formation proteins
Kinetochore proteins
CPC (chromosomal passenger complex)
9212 (AURKB)
SAC (spindle assembly checkpoint) factors
Protein kinases
9212 (AURKB)
Sister chromatid separation proteins
Aurora kinases
9212 (AURKB)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
17:complement(8204731..8210575)
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| AA seq |
344 aa
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA |
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| NT seq |
1035 nt +upstreamnt +downstreamnt
atggcccagaaggagaactcctacccctggccctacggccgacagacggctccatctggc
ctgagcaccctgccccagcgagtcctccggaaagagcctgtcaccccatctgcacttgtc
ctcatgagccgctccaatgtccagcccacagctgcccctggccagaaggtgatggagaat
agcagtgggacacccgacatcttaacgcggcacttcacaattgatgactttgagattggg
cgtcctctgggcaaaggcaagtttggaaacgtgtacttggctcgggagaagaaaagccat
ttcatcgtggcgctcaaggtcctcttcaagtcccagatagagaaggagggcgtggagcat
cagctgcgcagagagatcgaaatccaggcccacctgcaccatcccaacatcctgcgtctc
tacaactatttttatgaccggaggaggatctacttgattctagagtatgccccccgcggg
gagctctacaaggagctgcagaagagctgcacatttgacgagcagcgaacagccacgatc
atggaggagttggcagatgctctaatgtactgccatgggaagaaggtgattcacagagac
ataaagccagaaaatctgctcttagggctcaagggagagctgaagattgctgacttcggc
tggtctgtgcatgcgccctccctgaggaggaagacaatgtgtggcaccctggactacctg
cccccagagatgattgaggggcgcatgcacaatgagaaggtggatctgtggtgcattgga
gtgctttgctatgagctgctggtggggaacccaccctttgagagtgcatcacacaacgag
acctatcgccgcatcgtcaaggtggacctaaagttccccgcttccgtgcccatgggagcc
caggacctcatctccaaactgctcaggcataacccctcggaacggctgcccctggcccag
gtctcagcccacccttgggtccgggccaactctcggagggtgctgcctccctctgccctt
caatctgtcgcctga |
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