KEGG   Homo sapiens (human): 9320
Entry
9320              CDS       T01001                                 
Symbol
TRIP12, MRD49, TRIP-12, TRIPC, ULF
Name
(RefSeq) thyroid hormone receptor interactor 12
  KO
K10590  E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Disease
H00773  Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    9320 (TRIP12)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9320 (TRIP12)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     9320 (TRIP12)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   9320 (TRIP12)
SSDB
Motif
Pfam: HECT WWE UNC45-central HEAT_2 Maestro_HEAT
Other DBs
NCBI-GeneID: 9320
NCBI-ProteinID: NP_004229
OMIM: 604506
HGNC: 12306
Ensembl: ENSG00000153827
UniProt: Q14669
Structure
Position
2:complement(229763837..229923186)
AA seq 1992 aa
MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKT
GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ
QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLAS
KSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSP
SPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLA
SLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPE
SNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLG
PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKS
VVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE
QALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFV
ADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTP
PILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRS
PQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDS
RIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFG
VLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVV
GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSV
SSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRD
DDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKD
TISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAEC
LVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPG
EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKF
FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDD
GSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDE
SNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHD
GVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPT
SEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDR
AMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQY
ENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALP
FGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFD
IDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP
NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE
ELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTG
SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI
AAREGQQSFHLS
NT seq 5979 nt   +upstreamnt  +downstreamnt
atgtccaaccggcctaataacaatccaggggggtcactgcgacgttcacagaggaacact
gccggggcccaaccacaagacgactcaataggaggaagaagctgcagttcatcatctgct
gtgatagttccacaaccagaggatccagacagagccaatacttcagaaagacaaaaaacg
gggcaggtgcctaagaaagacaattctcgaggagtgaagcgcagtgctagtccagactac
aacaggaccaattctcctagctctgcaaaaaaaccaaaagcacttcagcatactgaatct
ccctcagaaacaaataagccacatagtaagtcaaagaagagacatttagaccaggagcaa
caactgaaatctgcacaatcaccatcaacaagcaaggctcataccaggaagagtggggcc
actggcggttcacggagtcagaaaagaaaaaggacagagagttcttgtgtaaagagtggc
tccgggtctgaatcaactggtgcagaagagagatctgcgaaacctaccaagctggcttca
aaatcagccacctcagccaaagctgggtgtagcaccatcactgattcttcttctgctgcc
tctacttcctcctcgtcttctgctgtagcctcggcctcctccactgtaccaccaggtgcc
agagtgaaacaaggaaaagatcagaacaaggccaggcgttcccgttcagcgtccagtccc
agccccagaagaagtagcagggaaaaggaacagagtaaaactggtggctcttcaaaattt
gattgggctgctcgtttcagccctaaagttagccttcctaaaacaaaactgtctcttcca
gggtcttctaagtcagagacatcaaaacctggaccttctggattacaggccaaattagca
agtttaagaaaatctacgaagaaacgcagtgagtctccacctgctgagctccccagtttg
aggcggagcacacgccaaaagaccacgggctcctgtgctagtaccagtcggcgaggctct
ggcctgggcaaaagaggagcagctgaagctcgtcgacaggagaaaatggcagaccctgaa
agcaaccaggaggcagtaaattcttcagctgctcggacagatgaagctccccaaggagct
gcaggggctgttggcatgaccacctctggggagagtgaatcagatgattccgagatggga
cgtttgcaagctttgttagaggcaaggggtcttccccctcacctatttggtcctcttggt
cctcggatgtcacagcttttccatagaacaattggaagtggagctagttctaaggcccag
cagctactacaaggattgcaagccagtgatgaaagtcaacagcttcaggcagttattgag
atgtgtcagttactggtcatgggaaatgaggagacactgggagggtttcctgtcaagagt
gttgttccagctttgattacgttacttcagatggagcacaattttgatattatgaaccat
gcttgtcgagccttaacatacatgatggaagcacttcctcgatcttctgctgttgtagta
gatgctattcctgtctttttagaaaagctgcaagttattcagtgtattgatgtggcagag
caggccttgactgccttggagatgttgtcacggagacatagtaaagccattctacaggcg
ggtggtttggcagactgcttgctgtacctagaattcttcagcataaatgcccaaagaaat
gcattagcaattgcagctaattgctgccagagtatcacgccagatgaatttcattttgtg
gcagattcactcccattgctaacccaaaggctaacacatcaggataaaaagtcagtagaa
agcacttgcctttgttttgcacgcctagtggacaacttccagcatgaggagaatttactc
cagcaggttgcttccaaagatctgcttacaaatgttcaacagctgttggtagtgactcca
cccattttaagttctgggatgtttataatggtggttcgcatgttttctctgatgtgttcc
aactgtccaactttagctgttcaacttatgaaacaaaacattgcagaaacgcttcacttt
ctcctgtgtggtgcctccaatggaagttgtcaggaacagattgatcttgttccacgaagc
cctcaagagttgtatgaactgacatctctgatttgtgaacttatgccatgtttaccaaaa
gaaggcatttttgcagttgataccatgttgaagaagggaaatgcacagaacacagatggt
gcgatatggcagtggcgtgatgatcggggcctctggcatccatataacaggattgacagc
cggatcattgagcaaatcaatgaggacacgggaacagcacgtgccattcagagaaaacct
aacccgttagccaatagtaacactagtggatattcagagtcaaagaaggatgatgctcga
gcacagcttatgaaagaggatccggaactggctaagtcttttattaagacattatttggt
gttctttatgaagtgtatagttcctcagcaggacctgcggtcagacataagtgccttaga
gcaattcttaggataatttattttgcggatgctgaacttctgaaggatgttctgaaaaat
catgctgtttcaagtcacattgcttccatgctgtcaagccaagacctgaagatagtagtg
ggagcacttcagatggcagaaattttaatgcagaagttacctgatatttttagtgtttac
ttcagaagagaaggtgtaatgcatcaagtaaaacacttagcagaatcagagtctttgttg
acaagtccaccaaaggcatgtacgaatggatcgggatccatgggatccacaacttcagtc
agcagtgggacagccacagctgccactcatgctgcagctgacttgggatcacccagcttg
cagcacagcagggatgattctttagatctcagccctcaaggtcgattaagtgatgttcta
aagagaaaacgactgccaaaacgagggccaagaaggccaaagtactcacctccaagagat
gatgacaaagtagacaatcaagctaaaagccccaccactactcagtcacctaaatcttct
ttcctggcaagcttgaatccaaaaacatggggaaggttaagtacacagtccaacagcaac
aacattgagccagcacggactgcgggaggtagtggccttgccagggctgcctcaaaggat
accatctccaataatagagaaaaaattaaaggttggattaaggagcaggcacataaattt
gtagaacgttatttcagttctgagaatatggatggaagcaaccctgcattgaatgtcctt
cagagactttgtgctgcaaccgaacaactcaacctccaggtggatggtggagctgagtgc
cttgtagaaatccgtagcatagtctcagagtcagatgtttcatcatttgaaatccaacat
agtggatttgtgaagcagctgttgctttatttgacatctaaaagtgaaaaggatgctgtg
agcagagagatcagattaaagcgatttcttcatgtatttttttcttctccacttcctgga
gaagagcccattggaagagtggaaccagtgggtaatgcacctttgttggcattagttcac
aagatgaacaactgcctcagccagatggaacaatttccagtcaaagtacatgatttccct
agtggaaatgggacaggaggcagcttttctctcaacagaggatcacaggctttaaaattt
ttcaacacacatcaattaaaatgccagttacaaaggcatccagactgtgcaaatgtgaag
cagtggaagggtggacctgtcaagattgaccctctggctttggtacaagccatcgagaga
taccttgtagttagagggtatggaagagtaagagaagatgatgaagacagcgatgacgat
ggatcagatgaggaaatagatgagtctctggctgctcagttcctaaattcaggaaatgta
agacacaggctgcagttttatattggagaacatttgctgccgtataacatgactgtgtat
caggcagtacggcagtttagtatacaggctgaagatgaaagagaatccacagatgatgag
agcaatcctctaggcagagctggtatttggacaaagactcatacaatatggtataaacct
gtgagagaggatgaagaaagtaataaagattgtgttggtggtaaaagaggaagagcccaa
acagctccaacgaaaacttcccctagaaatgcaaaaaagcatgatgagttatggcacgat
ggagtgtgcccatcagtatcaaatcctttagaagtttacctcattcccacaccacctgaa
aatataacatttgaagacccgtcattagatgtgatccttcttttaagagttttacatgct
atcagtcgatactggtattacttgtatgataatgcaatgtgcaaggaaattattccaact
agtgaatttattaacagtaagttaacagcaaaagcaaataggcaacttcaagatccttta
gtaatcatgacaggaaacatcccaacatggcttactgagctaggaaaaacctgcccattt
ttctttccttttgatacccggcaaatgcttttttatgtaactgcatttgatcgggaccga
gcaatgcaaagattacttgataccaacccagaaatcaaccagtctgattctcaagatagc
agagttgcacctagattggatagaaaaaaacgtactgtgaaccgagaggagctgctgaaa
caggcggagtctgtgatgcaggacctcggcagctcacgggccatgttagaaatccagtat
gaaaatgaggttggtacaggtcttgggcctacactggagttttatgcgcttgtatctcag
gaactacagagagctgacttgggtctttggagaggtgaagaagtaactcttagcaatcca
aaagggagccaagaagggaccaagtatattcaaaacctccagggcctgtttgcgcttccc
tttggtaggacagcaaagccagctcatatcgcaaaggttaagatgaagtttcgcttctta
ggaaaattaatggccaaggctatcatggatttcagattggtggaccttccccttggctta
cccttttataaatggatgctacggcaagaaacttcactgacatcacacgatttgtttgac
atcgacccagttgtagccagatcagtttatcacctagaagacattgtcagacagaagaaa
agacttgaacaagataaatcccagaccaaagagagtctacagtatgcattagaaaccttg
actatgaatggctgctcagttgaagatctaggactggatttcactctgccagggtttccc
aatatcgaactgaagaaaggagggaaggatataccagtcactatccacaatttagaggag
tatctaagactggttatattctgggcactaaatgaaggcgtttctaggcaatttgattcg
ttcagagatggatttgaatcagtcttcccactcagtcatcttcagtacttctacccggag
gaactggatcagctcctttgtggcagtaaagcagacacttgggatgcaaagacactgatg
gaatgctgtaggcctgatcatggttatactcatgacagtcgggctgtgaagtttttgttt
gagattctcagtagttttgataatgagcagcagaggttatttctccagtttgtgactggt
agcccaagattgcctgttggaggattccggagtttgaatccacctttgacaattgtccga
aagacgtttgaatcaacagaaaacccagatgacttcttgccctctgtaatgacttgtgtg
aactatcttaagttgccggactattcaagcattgagataatgcgtgaaaaactgttgata
gcagcaagagaagggcagcagtcgttccatctttcctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (31)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (98)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (96)   
DNA sequence (118)   
   RefSeq(nuc) (96)   
   GenBank (11)   
   EMBL (11)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (268)   

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