KEGG   Homo sapiens (human): 9353
Entry
9353              CDS       T01001                                 
Symbol
SLIT2, SLIL3, Slit-2
Name
(RefSeq) slit guidance ligand 2
  KO
K06839  slit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    9353 (SLIT2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    9353 (SLIT2)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Axon guidance molecules
   9353 (SLIT2)
SSDB
Motif
Pfam: LRR_8 LRR_4 LRR_5 EGF Laminin_G_1 Laminin_G_2 LRRNT LRR_9 LRR_1 LRRCT hEGF DL-JAG_EGF-like JAG1-like_EGF2 EGF_3
Other DBs
NCBI-GeneID: 9353
NCBI-ProteinID: NP_004778
OMIM: 603746
HGNC: 11086
Ensembl: ENSG00000145147
UniProt: O94813
Structure
Position
4:20251905..20620561
AA seq 1529 aa
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
KYSFECTDGSSFVDEVEKVVKCGCTRCVS
NT seq 4590 nt   +upstreamnt  +downstreamnt
atgcgcggcgttggctggcagatgctgtccctgtcgctggggttagtgctggcgatcctg
aacaaggtggcaccgcaggcgtgcccggcgcagtgctcttgctcgggcagcacagtggac
tgtcacgggctggcgctgcgcagcgtgcccaggaatatcccccgcaacaccgagagactg
gatttaaatggaaataacatcacaagaattacgaagacagattttgctggtcttagacat
ctaagagttcttcagcttatggagaataagattagcaccattgaaagaggagcattccag
gatcttaaagaactagagagactgcgtttaaacagaaatcaccttcagctgtttcctgag
ttgctgtttcttgggactgcgaagctatacaggcttgatctcagtgaaaaccaaattcag
gcaatcccaaggaaagctttccgtggggcagttgacataaaaaatttgcaactggattac
aaccagatcagctgtattgaagatggggcattcagggctctccgggacctggaagtgctc
actctcaacaataacaacattactagactttctgtggcaagtttcaaccatatgcctaaa
cttaggacttttcgactgcattcaaacaacctgtattgtgactgccacctggcctggctc
tccgactggcttcgccaaaggcctcgggttggtctgtacactcagtgtatgggcccctcc
cacctgagaggccataatgtagccgaggttcaaaaacgagaatttgtctgcagtggtcac
cagtcatttatggctccttcttgtagtgttttgcactgccctgccgcctgtacctgtagc
aacaatatcgtagactgtcgtgggaaaggtctcactgagatccccacaaatcttccagag
accatcacagaaatacgtttggaacagaacacaatcaaagtcatccctcctggagctttc
tcaccatataaaaagcttagacgaattgacctgagcaataatcagatctctgaacttgca
ccagatgctttccaaggactacgctctctgaattcacttgtcctctatggaaataaaatc
acagaactccccaaaagtttatttgaaggactgttttccttacagctcctattattgaat
gccaacaagataaactgccttcgggtagatgcttttcaggatctccacaacttgaacctt
ctctccctatatgacaacaagcttcagaccatcgccaaggggaccttttcacctcttcgg
gccattcaaactatgcatttggcccagaacccctttatttgtgactgccatctcaagtgg
ctagcggattatctccataccaacccgattgagaccagtggtgcccgttgcaccagcccc
cgccgcctggcaaacaaaagaattggacagatcaaaagcaagaaattccgttgttcagct
aaagaacagtatttcattccaggtacagaagattatcgatcaaaattaagtggagactgc
tttgcggatctggcttgccctgaaaagtgtcgctgtgaaggaaccacagtagattgctct
aatcaaaagctcaacaaaatcccggagcacattccccagtacactgcagagttgcgtctc
aataataatgaatttaccgtgttggaagccacaggaatctttaagaaacttcctcaatta
cgtaaaataaactttagcaacaataagatcacagatattgaggagggagcatttgaagga
gcatctggtgtaaatgaaatacttcttacgagtaatcgtttggaaaatgtgcagcataag
atgttcaagggattggaaagcctcaaaactttgatgttgagaagcaatcgaataacctgt
gtggggaatgacagtttcataggactcagttctgtgcgtttgctttctttgtatgataat
caaattactacagttgcaccaggggcatttgatactctccattctttatctactctaaac
ctcttggccaatccttttaactgtaactgctacctggcttggttgggagagtggctgaga
aagaagagaattgtcacgggaaatcctagatgtcaaaaaccatacttcctgaaagaaata
cccatccaggatgtggccattcaggacttcacttgtgatgacggaaatgatgacaatagt
tgctccccactttctcgctgtcctactgaatgtacttgcttggatacagtcgtccgatgt
agcaacaagggtttgaaggtcttgccgaaaggtattccaagagatgtcacagagttgtat
ctggatggaaaccaatttacactggttcccaaggaactctccaactacaaacatttaaca
cttatagacttaagtaacaacagaataagcacgctttctaatcagagcttcagcaacatg
acccagctcctcaccttaattcttagttacaaccgtctgagatgtattcctcctcgcacc
tttgatggattaaagtctcttcgattactttctctacatggaaatgacatttctgttgtg
cctgaaggtgctttcaatgatctttctgcattatcacatctagcaattggagccaaccct
ctttactgtgattgtaacatgcagtggttatccgactgggtgaagtcggaatataaggag
cctggaattgctcgttgtgctggtcctggagaaatggcagataaacttttactcacaact
ccctccaaaaaatttacctgtcaaggtcctgtggatgtcaatattctagctaagtgtaac
ccctgcctatcaaatccgtgtaaaaatgatggcacatgtaatagtgatccagttgacttt
taccgatgcacctgtccatatggtttcaaggggcaggactgtgatgtcccaattcatgcc
tgcatcagtaacccatgtaaacatggaggaacttgccacttaaaggaaggagaagaagat
ggattctggtgtatttgtgctgatggatttgaaggagaaaattgtgaagtcaacgttgat
gattgtgaagataatgactgtgaaaataattctacatgtgtcgatggcattaataactac
acatgcctttgcccacctgagtatacaggtgagttgtgtgaggagaagctggacttctgt
gcccaggacctgaacccctgccagcacgattcaaagtgcatcctaactccaaagggattc
aaatgtgactgcacaccagggtacgtaggtgaacactgcgacatcgattttgacgactgc
caagacaacaagtgtaaaaacggagcccactgcacagatgcagtgaacggctatacgtgc
atatgccccgaaggttacagtggcttgttctgtgagttttctccacccatggtcctccct
cgtaccagcccctgtgataattttgattgtcagaatggagctcagtgtatcgtcagaata
aatgagccaatatgtcagtgtttgcctggctatcagggagaaaagtgtgaaaaattggtt
agtgtgaattttataaacaaagagtcttatcttcagattccttcagccaaggttcggcct
cagacgaacataacacttcagattgccacagatgaagacagcggaatcctcctgtataag
ggtgacaaagaccatatcgcggtagaactctatcgggggcgtgttcgtgccagctatgac
accggctctcatccagcttctgccatttacagtgtggagacaatcaatgatggaaacttc
cacattgtggaactacttgccttggatcagagtctctctttgtccgtggatggtgggaac
cccaaaatcatcactaacttgtcaaagcagtccactctgaattttgactctccactctat
gtaggaggcatgccagggaagagtaacgtggcatctctgcgccaggcccctgggcagaac
ggaaccagcttccacggctgcatccggaacctttacatcaacagtgagctgcaggacttc
cagaaggtgccgatgcaaacaggcattttgcctggctgtgagccatgccacaagaaggtg
tgtgcccatggcacatgccagcccagcagccaggcaggcttcacctgcgagtgccaggaa
ggatggatggggcccctctgtgaccaacggaccaatgacccttgccttggaaataaatgc
gtacatggcacctgcttgcccatcaatgcgttctcctacagctgtaagtgcttggagggc
catggaggtgtcctctgtgatgaagaggaggatctgtttaacccatgccaggcgatcaag
tgcaagcatgggaagtgcaggctttcaggtctggggcagccctactgtgaatgcagcagt
ggatacacgggggacagctgtgatcgagaaatctcttgtcgaggggaaaggataagagat
tattaccaaaagcagcagggctatgctgcttgccaaacaaccaagaaggtgtcccgatta
gagtgcagaggtgggtgtgcaggagggcagtgctgtggaccgctgaggagcaagcggcgg
aaatactctttcgaatgcactgacggctcctcctttgtggacgaggttgagaaagtggtg
aagtgcggctgtacgaggtgtgtgtcctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (17)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (43)   
   RefSeq(nuc) (13)   
   GenBank (15)   
   EMBL (15)   
3D Structure (4)   
   PDB (4)   
Protein domain (14)   
   Pfam (14)   
All databases (104)   

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