KEGG   Homo sapiens (human): 9380
Entry
9380              CDS       T01001                                 
Symbol
GRHPR, GLXR, GLYD, PH2
Name
(RefSeq) glyoxylate and hydroxypyruvate reductase
  KO
K00049  glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00260  Glycine, serine and threonine metabolism
hsa00620  Pyruvate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa01100  Metabolic pathways
Disease
H00117  Primary hyperoxaluria
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    9380 (GRHPR)
   00630 Glyoxylate and dicarboxylate metabolism
    9380 (GRHPR)
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    9380 (GRHPR)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.79  glyoxylate reductase (NADP+)
     9380 (GRHPR)
    1.1.1.81  hydroxypyruvate reductase
     9380 (GRHPR)
SSDB
Motif
Pfam: 2-Hacid_dh_C 2-Hacid_dh NAD_binding_2 F420_oxidored KR IlvN Shikimate_DH ThiF
Other DBs
NCBI-GeneID: 9380
NCBI-ProteinID: NP_036335
OMIM: 604296
HGNC: 4570
Ensembl: ENSG00000137106
UniProt: Q9UBQ7 A0A384N605
Structure
Position
9:37422435..37439494
AA seq 328 aa
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL
NT seq 987 nt   +upstreamnt  +downstreamnt
atgagaccggtgcgactcatgaaggtgttcgtcacccgcaggatacccgccgagggtagg
gtcgcgctcgcccgggcggcagactgtgaggtggagcagtgggactcggatgagcccatc
cctgccaaggagctagagcgaggtgtggcgggggcccacggcctgctctgcctcctctcc
gaccacgtggacaagaggatcctggatgctgcaggggccaatctcaaagtcatcagcacc
atgtctgtgggcatcgaccacttggctttggatgaaatcaagaagcgtgggatccgagtt
ggctacaccccagatgtcctgacagataccaccgccgaactcgcagtctccctgctactt
accacctgccgccggttgccggaggccatcgaggaagtgaagaatggtggctggacctcg
tggaagcccctctggctgtgtggctatggactcacgcagagcactgtcggcatcatcggg
ctggggcgcataggccaggccattgctcggcgtctgaaaccattcggtgtccagagattt
ctgtacacagggcgccagcccaggcctgaggaagcagcagaattccaggcagagtttgtg
tctacccctgagctggctgcccaatctgatttcatcgtcgtggcctgctccttaacacct
gcaaccgagggactctgcaacaaggacttcttccagaagatgaaggaaacagctgtgttc
atcaacatcagcaggggcgacgtcgtaaaccaggacgacctgtaccaggccttggccagt
ggtaagattgcagctgctggactggatgtgacgagcccagaaccactgcctacaaaccac
cctctcctgaccctgaagaactgtgtgattctgccccacattggcagtgccacccacaga
acccgcaacaccatgtccttgttggcagctaacaacttgctggctggcctgagaggggag
ccgatgcctagtgaactcaagctgtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (17)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (47)   
   RefSeq(nuc) (17)   
   GenBank (15)   
   EMBL (15)   
3D Structure (4)   
   PDB (4)   
Protein domain (8)   
   Pfam (8)   
All databases (118)   

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