KEGG   Homo sapiens (human): 9453
Entry
9453              CDS       T01001                                 
Symbol
GGPS1, GGPPS, GGPPS1, MDHLO, MUDHLOV
Name
(RefSeq) geranylgeranyl diphosphate synthase 1
  KO
K00804  geranylgeranyl diphosphate synthase, type III [EC:2.5.1.1 2.5.1.10 2.5.1.29]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00367  C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Network
nt06034  Cholesterol biosynthesis
  Element
N01635  Mevalonate pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    9453 (GGPS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases [BR:hsa01006]
    9453 (GGPS1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.1  dimethylallyltranstransferase
     9453 (GGPS1)
    2.5.1.10  (2E,6E)-farnesyl diphosphate synthase
     9453 (GGPS1)
    2.5.1.29  geranylgeranyl diphosphate synthase
     9453 (GGPS1)
Prenyltransferases [BR:hsa01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   9453 (GGPS1)
SSDB
Motif
Pfam: polyprenyl_synt
Other DBs
NCBI-GeneID: 9453
NCBI-ProteinID: NP_001032354
OMIM: 606982
HGNC: 4249
Ensembl: ENSG00000152904
UniProt: O95749
Structure
Position
1:235327216..235344532
AA seq 300 aa
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
NT seq 903 nt   +upstreamnt  +downstreamnt
atggagaagactcaagaaacagtccaaagaattcttctagaaccctataaatacttactt
cagttaccaggtaaacaagtgagaaccaaactttcacaggcatttaatcattggctgaaa
gttccagaggacaagctacagattattattgaagtgacagaaatgttgcataatgccagt
ttactcatcgatgatattgaagacaactcaaaactccgacgtggctttccagtggcccac
agcatctatggaatcccatctgtcatcaattctgccaattacgtgtatttccttggcttg
gagaaagtcttaacccttgatcacccagatgcagtgaagctttttacccgccagcttttg
gaactccatcagggacaaggcctagatatttactggagggataattacacttgtcccact
gaagaagaatataaagctatggtgctgcagaaaacaggtggactgtttggattagcagta
ggtctcatgcagttgttctctgattacaaagaagatttaaaaccgctacttaatacactt
gggctctttttccaaattagggatgattatgctaatctacactccaaagaatatagtgaa
aacaaaagtttttgtgaagatctgacagagggaaagttctcatttcctactattcatgct
atttggtcaaggcctgaaagcacccaggtgcagaatatcttgcgccagagaacagaaaac
atagatataaaaaaatactgtgtacattatcttgaggatgtaggttcttttgaatacact
cgtaatacccttaaagagcttgaagctaaagcctataaacagattgatgcacgtggtggg
aaccctgagctagtagccttagtaaaacacttaagtaagatgttcaaagaagaaaatgaa
taa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (2)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (38)   
   RefSeq(nuc) (6)   
   GenBank (16)   
   EMBL (16)   
3D Structure (6)   
   PDB (6)   
Protein domain (1)   
   Pfam (1)   
All databases (84)   

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