KEGG   Homo sapiens (human): 9563
Entry
9563              CDS       T01001                                 
Symbol
H6PD, CORTRD1, G6PDH, GDH, H6PDH
Name
(RefSeq) hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase
  KO
K13937  hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00030  Pentose phosphate pathway
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle)
hsa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
Network
nt06019  Steroid hormone biosynthesis
  Element
N00311  NADPH generation
Disease
H01111  Cortisone reductase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    9563 (H6PD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.47  glucose 1-dehydrogenase [NAD(P)+]
     9563 (H6PD)
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.31  6-phosphogluconolactonase
     9563 (H6PD)
SSDB
Motif
Pfam: Glucosamine_iso G6PD_C G6PD_N DUF5617
Other DBs
NCBI-GeneID: 9563
NCBI-ProteinID: NP_004276
OMIM: 138090
HGNC: 4795
Ensembl: ENSG00000049239
UniProt: O95479
Structure
Position
1:9234774..9271337
AA seq 791 aa
MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG
NT seq 2376 nt   +upstreamnt  +downstreamnt
atgtggaatatgctcatagtggcgatgtgcttggcccttctgggctgcctgcaagcccag
gagctccagggacatgtctccataatcctgctgggagcaactggggacctggctaagaag
tacttatggcagggactgttccagctgtacctggatgaagcggggaggggtcacagtttt
agcttccatggagctgctctgacagcccccaagcagggtcaagagctcatggccaaggcc
ctggaatccctctcctgccccaaggacatggcacccagtcactgtgcagagcacaaggat
cagttcctgcagctgagccagtaccgccaactgaagacggccgaggactatcaggccctg
aacaaggacatcgaggcacagctccagcacgcaggcctccgggaggctggcaggatcttc
tacttctcagtgccacccttcgcctatgaagacattgcccgcaacatcaacagtagctgc
cggccaggcccgggcgcctggctgcgggttgtccttgagaaaccctttggccatgaccac
ttctcagcccagcagctggccacagaactcgggacctttttccaggaggaggagatgtac
cgggtggaccattacttaggcaagcaggctgtggcgcagatcctgcctttccgagaccag
aaccgcaaggctttggacggcctctggaaccggcaccatgtggagcgggtggagatcatc
atgaaagagaccgtggatgctgaaggccgcaccagcttctatgaggagtacggtgtcatt
cgcgacgtcctccagaaccatctgacggaggtcctcaccctcgtggccatggagctgccc
cacaatgtcagcagtgcggaggctgtgctgcggcacaagcttcaggtcttccaggcgctg
cggggcctgcagaggggcagtgccgtcgtgggccagtaccagtcttacagtgagcaggtg
cgcagagagctgcagaagccagacagcttccacagcctgacgccgaccttcgcagccgtc
ctagtgcacattgacaaccttcgctgggagggcgtgcctttcatcctgatgtctggcaaa
gccttggacgagagagtgggctacgctcggatcttgttcaagaaccaggcctgctgtgtg
cagagcgaaaagcactgggccgcggcgcagagccagtgcctgccccggcagctcgtcttc
cacatcggccatggcgacctgggcagccctgccgtgctggtcagcaggaacctgttcagg
ccctccctgccctccagctggaaggaaatggagggaccacctgggctccgccttttcggc
agccctctgtccgattactacgcctacagccctgtgcgggagcgggacgcccactccgtc
ctcttatcccatatcttccatggccggaagaatttcttcatcaccacagagaacttgctg
gcctcctggaacttctggacccctctgctggagagcctggcccataaggccccacgcctc
taccctggaggagctgagaatggccgtctgttggactttgagttcagtagcggccggttg
ttcttttcccagcagcagccggagcagctggtgccagggccagggccggccccaatgccc
agtgacttccaggtcctcagggccaagtaccgagagagcccgctggtctccgcctggtcc
gaggagctgatctctaagctggctaatgacatcgaggccaccgctgtgcgagccgtgcgg
cgctttggccagttccacctggcactgtcggggggctcgagccccgtggccctgttccag
cagctggccacggcgcactatggcttcccctgggcccacacgcacctgtggctggttgac
gagcgctgcgtcccactctcagacccggagtccaacttccagggcctgcaggcccacctg
ctgcagcacgtccggatcccctactacaacatccaccccatgcctgtgcacctgcagcag
cggctctgcgccgaggaggaccagggcgcccagatctatgccagggagatctcagccctg
gtggccaacagcagcttcgacctggtgctgctgggcatgggtgccgacgggcacacagcc
tccctcttcccacagtcacccactggcctggatggcgagcagctggtcgtgctgaccacg
agcccctcccagccacaccgccgcatgagccttagcctgcctctcatcaaccgcgccaag
aaggtggcagtcctggtcatgggcaggatgaagcgtgagatcaccacgctggtgagccgg
gtgggccatgagcccaagaagtggcccatctcgggtgtcctgccgcactccggccagctg
gtgtggtacatggactacgacgccttcctgggatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (40)   
   RefSeq(nuc) (14)   
   GenBank (13)   
   EMBL (13)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (4)   
All databases (107)   

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