KEGG   Homo sapiens (human): 9656
Entry
9656              CDS       T01001                                 
Symbol
MDC1, NFBD1
Name
(RefSeq) mediator of DNA damage checkpoint 1
  KO
K20780  mediator of DNA damage checkpoint protein 1
Organism
hsa  Homo sapiens (human)
Network
nt06506  Double-strand break repair
  Element
N01439  Double-strand break signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    9656 (MDC1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    9656 (MDC1)
SSDB
Motif
Pfam: BRCT_2 FHA RTT107_BRCT_5 BRCT Yop-YscD_cpl
Other DBs
NCBI-GeneID: 9656
NCBI-ProteinID: NP_055456
OMIM: 607593
HGNC: 21163
Ensembl: ENSG00000137337
UniProt: Q14676 A0A1U9XBC1 A1Z5I9
Structure
Position
6:complement(30699807..30717281)
AA seq 2089 aa
MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMP
DCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQEL
ILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRM
VKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRG
ATVEAKQSEAEVVTEIQLEKDQPLVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSD
TDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRG
PGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLK
ESQPAIWNRDAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTKIRAL
VRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKK
HQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQL
PAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQ
PQREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQ
AFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLS
PPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLP
ERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEI
QEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKG
QASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRI
RAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRK
TRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPK
PTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPE
TVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPV
TSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVK
TPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTE
QPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRS
SVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASA
STDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRT
NRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPH
PTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQ
SKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHK
PCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFT
PELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPK
PGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAGSA
AEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFG
FSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVI
TCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST
NT seq 6270 nt   +upstreamnt  +downstreamnt
atggaggacacccaggctattgactgggatgttgaagaagaggaggagacagagcaatcc
agtgaatccttgaggtgtaacgtggagccagtagggcggctacatatctttagtggtgcc
catggaccagaaaaagatttcccactacacctcgggaagaatgtggtaggccgaatgcct
gactgctctgtggccctgccctttccatctatctccaaacaacatgcagagattgaaatc
ttagcctgggacaaggcacctatcctccgagactgtgggagccttaatggtactcaaatc
ctgagacctcctaaggttttgagccctggggtgagtcaccgtctgagggaccaggaattg
attctctttgctgacttgctctgccagtaccatcgcctggatgtctctctgccctttgtc
tcccggggccctctgacagtagaagagacacccagagtacagggagaaactcaaccccag
aggcttctgttggctgaggactcggaggaggaagtagattttctttctgaaaggcgtatg
gtaaaaaaatcaaggaccacatcttcctctgtgatagttccagagagtgatgaagagggg
cattccccggtcctgggcggccttgggccgccttttgccttcaatttgaacagtgacaca
gatgtggaagaaggtcagcaaccagccacagaggaggcctcctcagctgccagaagaggt
gccactgtagaggcaaagcagtctgaagctgaagttgtaactgaaatccagcttgaaaag
gatcagcctttagtgaaggagagggacaatgatacaaaagtcaagaggggtgcagggaat
ggggtggttccagctggggtgattctggagaggagccaacctcctggagaggacagtgac
acagatgtggatgatgacagcaggcctcctggaaggccagctgaggtccatttggaaagg
gctcagccttttggcttcatcgacagcgacactgatgcggaagaagagaggatcccagca
accccagttgtcattcctatgaagaagaggaagatcttccatggagtaggtacaaggggt
cctggagcaccaggcctggcccatctgcaggagagccaggctggtagtgatacagatgtg
gaagaaggcaaggccccacaggctgtccctctggagaaaagccaagcttccatggttatc
aacagcgatacagatgacgaggaagaagtctcagcagcgctgactttggcacatctgaaa
gagagccagcctgctatatggaacagagatgcagaagaggacatgccccaacgtgtggtc
cttctgcagcgaagccaaaccaccactgagagagacagtgacacagacgtggaggaggaa
gagctcccagtggaaaatagagaagctgtcctcaaggatcacacaaagattagagccctt
gttagagcacattcagaaaaggaccaacctccttttggggacagtgatgacagtgtggaa
gcagataagagctcacctgggatccacctggagagaagccaagcctccaccacagtggac
atcaacacacaagtggagaaggaagtcccgccagggtcagccattatacatataaagaag
catcaggtgtctgtggaggggacaaatcaaacagatgtgaaagcagttgggggaccagca
aagctgcttgtggtatctctagaggaagcctggcctctgcatggggactgtgaaacagat
gcagaggagggcacctccctaacagcctcagtagttgcagatgtaagaaagagccagctt
ccagcagaaggggatgctggggcagagtgggctgcagctgttcttaagcaggagagagct
catgaggtgggggcccagggtgggccacctgtggcacaagtggagcaggacctccctatc
tcaagagagaacctcacagatctggtggtggacacagacactctaggggaatccacccag
ccacagagagagggagcccaggtccccacaggaagggagagagaacaacatgtgggtggg
accaaggactctgaagacaactatggtgattctgaagatctggacctacaagctacccag
tgctttctggagaatcagggcctggaagcagtccagagcatggaggatgaacctacccag
gccttcatgttgactccaccccaagagcttggcccttcccattgcagcttccagacaaca
ggtaccctagatgaaccatgggaggtcctggctacacagccattctgtctgagagagtct
gaggactctgagacccagccttttgacacgcaccttgaggcctatggaccttgcctgtct
ccacctagggcaataccaggagaccaacatccagagagcccagttcacacagagccaatg
gggattcaaggcagagggaggcagactgtggataaagtcatgggtataccaaaagaaaca
gcagagagggtgggccctgagagagggccattggagagagaaactgagaaactgctacca
gaaagacagacagatgtgacaggagaggaagaattaaccaaggggaaacaggacagagaa
caaaaacagttgttagctagagacacccagagacaagaatctgacaaaaatggggaaagt
gcaagtcctgaaagagatagggagagtttgaaggtagaaattgagacatctgaggaaata
caagagaaacaagtacagaagcagacccttccaagcaaagcatttgagagagaagtagag
agaccagtagcaaacagagagtgcgatccagccgagttagaagagaaggtgcccaaagtg
atcctggagagagatacacagagaggggagccagagggagggagccaggaccagaaaggg
caggcctccagcccaacaccagagcctggggtgggggcgggggaccttccgggacctacc
tcagcccccgtaccttctgggagccagtcaggtggaaggggatccccagtgagccccagg
aggcatcagaaaggcctcctgaattgcaagatgccacctgctgagaaggcttccaggatc
agagctgctgagaaggtttccaggggcgatcaggaatctccagatgcttgtctgcctcct
acagtacctgaagccccagccccaccccaaaagccccttaactctcagagccagaaacat
cttgcacctccgccccttctttctccccttttaccttctatcaagccaaccgttcgtaag
accaggcaagatgggagtcaggaagctccagaggctcccttgtcctcagagctggagcct
ttccacccaaagcctaaaattagaactcggaagtcctccagaatgacaccctttccagct
acctctgctgcccctgagccccacccttccacctccacagcccagccagtcactcccaag
cccacatctcaggccactaggagcaggacaaataggtcctctgtcaagacccctgaacca
gttgtccccacagcccctgagctccagccttccacctccacagaccagcctgtcacctct
gagcccacatctcaggttactaggggaagaaaaagtagatcctctgtcaagacccctgaa
acagttgtgcccacagcccttgagctccagccttccacctccaccgaccgacctgtcacc
tctgaacccacctctcaggctactaggggaagaaaaaatagatcctctgtcaagacccct
gaaccagttgtccccacagcccctgagctccagccttccacctccacagaccagcctgtc
acttctgagcccacatatcaggctactaggggaagaaaaaatagatcctctgtcaagacc
cctgaaccagttgtgcccacagcccctgagctccggccttccacctccacagaccgacct
gtcacccccaagcccacatctcggaccactaggagcaggacaaatatgtcctctgtcaag
acccctgaaacagttgtccccacagcccctgagctccagatttccacctccacagaccaa
cctgtcacccctaagcccacatctcggaccactaggagcaggacaaatatgtcctctgtg
aagaaccctgaatcaactgtccctatagcccctgagctcccaccttccacctccacagag
cagcctgtcacccctgagcccacatctcgggctactaggggaagaaaaaatagatcctct
ggcaagacccctgaaacacttgtccccacagcccctaagctcgagccttccacttccaca
gaccaacctgtcactcctgagcccacatctcaggccaccaggggcaggacaaataggtcc
tctgtgaagacccctgaaacagttgtccccacagcccctgagctccagccttccacctcc
acagaccagcctgttacccctgagcctacgtctcaggctactaggggaagaacagataga
tcctctgtcaagactcctgaaacagttgtccccacagcccctgagctacaggcttccgcc
tccacagaccagcctgtcacctctgagcccacatctcggaccactaggggaagaaaaaat
cggtcctctgtcaagacccctgaaacagttgtgcccgcagcccctgagctccagccttcc
acctccacagaccaacctgtcacccctgagcccacatctcgggccactaggggcaggaca
aataggtcctctgtcaagacccctgaatcaattgtccctatagcccctgagcttcagcct
tccacctccagaaaccagcttgtcacccctgagcccacatctcgggccactaggtgcagg
acaaataggtcctctgtcaagacccctgagccagttgtccccacagcccctgagccccat
cctaccacctccacagaccagcctgtcacccccaagctcacatctagggccactaggaga
aagacaaataggtcctctgtcaagactcccaaaccagttgaaccagcagcctctgatctt
gagccttttacccccacagaccagtccgtcacccctgaggccatagctcagggtggtcag
agcaaaacactgaggtcttccacagtaagagctatgccggttcctaccacccctgaattc
caatctcctgtcaccacagaccagcctatttcccctgagcctattactcaacccagttgc
atcaagaggcagagagccgctgggaaccctggctccctcgcagctcccattgaccataag
ccttgctctgcacccttggaacctaaatcccaggcctcaaggaaccaaagatggggagca
gtgagagcagctgaatcccttacagccattcctgagcctgcctctccccagcttcttgag
acaccaattcatgcctcccagatccaaaaggtggaaccagcaggtagatctaggttcacc
ccggagctccagcctaaggcctctcaaagccgcaagaggtctttagctaccatggattca
ccaccacatcaaaaacagccccaaagaggggaagtctcccagaagacagtgattatcaag
gaagaggaagaagatactgcagagaagccagggaaggaagaggatgtcgtgactccaaaa
ccaggcaagagaaagagagaccaggcagaggaggagcccaacagaataccaagccgcagc
ctccgacggaccaaacttaaccaagaatcaacagcccccaaagtgctcttcacaggagtg
gtggatgctcggggagagcgggctgtgctggcactggggggaagtctggctggttcagcg
gcagaggcttcccacctggtcactgatcgcatccgccggacagtcaagttcctgtgtgcc
ctggggcggggaatccccattctgtccctggactggctgcatcagtcccgcaaggctggt
ttcttcttacccccggatgaatatgtggtgaccgaccctgagcaagagaagaactttggc
tttagccttcaagacgcactgagcagggctcgggagcgaaggctgctagagggctatgag
atctatgtgacccctggagtccagccaccaccacctcagatgggagagattattagctgc
tgtggaggcacatacctacccagcatgcctcggtcctataagcctcagagagttgtgatc
acatgccctcaggacttccctcattgctccattccactacgggttgggctgcccctcctc
tcgcctgagttcctgctgactggagtgctgaagcaggaagccaagccagaggcctttgtc
ctctcccctttggagatgtcatccacctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (80)   
   KEGG ORTHOLOGY (1)   
   RefGene (74)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (138)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (134)   
DNA sequence (158)   
   RefSeq(nuc) (134)   
   GenBank (12)   
   EMBL (12)   
3D Structure (10)   
   PDB (10)   
Protein domain (5)   
   Pfam (5)   
All databases (397)   

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