KEGG   Homo sapiens (human): 9682
Entry
9682              CDS       T01001                                 
Symbol
KDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A
Name
(RefSeq) lysine demethylase 4A
  KO
K06709  [histone H3]-trimethyl-L-lysine9/36 demethylase [EC:1.14.11.66 1.14.11.69]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    9682 (KDM4A)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.66  [histone H3]-trimethyl-L-lysine9 demethylase
     9682 (KDM4A)
    1.14.11.69  [histone H3]-trimethyl-L-lysine36 demethylase
     9682 (KDM4A)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    9682 (KDM4A)
SSDB
Motif
Pfam: JmjC zf-HC5HC2H_2 Tudor_2 PHD_2 JmjN zf-HC5HC2H PHD Tudor_5 53-BP1_Tudor LBR_tudor DUF4537
Other DBs
NCBI-GeneID: 9682
NCBI-ProteinID: NP_055478
OMIM: 609764
HGNC: 22978
Ensembl: ENSG00000066135
UniProt: O75164
Structure
Position
1:43650149..43705518
AA seq 1064 aa
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYD
DIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERK
YWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRH
KMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYG
KQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDL
SSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEE
QAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPL
SKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNET
MAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSL
RGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRT
AGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEG
EVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSV
ASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
NT seq 3195 nt   +upstreamnt  +downstreamnt
atggcttctgagtctgaaactctgaatcccagtgctaggataatgaccttttatccaact
atggaagagttccgaaacttcagtagatacattgcctacattgaatcccaaggagctcat
cgggcagggctagccaaggttgttcctccaaaagagtggaagccacgagcatcctatgat
gacattgatgatttggtcattcctgcccccattcaacagctggtgacggggcagtctggc
ctctttactcagtacaacatacagaagaaagccatgactgttcgagagttccgcaagata
gccaatagcgataagtactgtaccccacgctatagtgagtttgaagagctcgagcggaaa
tactggaaaaatcttacattcaatcctccaatctatggtgcagatgtgaatggtaccctc
tatgaaaagcatgttgatgagtggaatattggccggctgagaacaatcctggacttggtg
gaaaaggagagtgggatcaccattgagggtgtgaacaccccatacctgtactttggcatg
tggaagacatcctttgcttggcacactgaagacatggacctctacagcatcaactacctg
cactttggagaaccaaagtcctggtactctgttccacctgagcatggaaagcggttggaa
cgcctcgccaaaggctttttcccaggaagtgctcaaagctgtgaggcatttctccgccac
aagatgaccctgatttccccgttaatgctgaagaaatatggaattccctttgacaaggtg
actcaagaggctggagagtttatgatcactttcccttatggttaccatgccggctttaac
catggttttaactgtgcggagtctaccaattttgctacccgtcggtggattgagtacggc
aagcaagctgtgctgtgctcctgtagaaaggacatggtgaagatctccatggatgtgttt
gtgagaaagttccagccagaaaggtacaaactttggaaagctgggaaggacaacacagtt
attgaccatactctgcccacgccagaagcagctgagtttcttaaggagagtgaactgcct
ccaagagctggcaacgaggaggagtgcccagaggaggacatggaaggggtggaggatgga
gaggaaggagacctgaagacaagcctggccaagcaccgaatagggacaaagaggcaccga
gtttgtcttgaaataccacaggaggtgagtcagagtgagctcttccccaaggaggatctg
agttctgagcagtatgagatgacggagtgcccggcagccctcgcccctgtgaggcccacc
catagctctgtgcggcaagttgaggatggtcttaccttcccagattattctgactccact
gaagtcaaatttgaagagcttaaaaatgtcaaactagaagaggaggatgaggaggaagaa
caagcagcagctgccttggatctttctgtgaatcctgcgtctgtagggggacgccttgtc
ttctcaggctccaaaaagaaatcatcttctagcctgggctctggctcttcacgggattct
atctcttctgattcagaaactagtgagcctctctcctgccgagcccaagggcaaacggga
gttctcactgtgcacagttatgccaaaggggatggcagggtcactgtgggagagccatgc
acgaggaagaaaggaagcgccgctagaagtttcagtgagcgggagctggcagaggttgca
gatgaatacatgttttccctagaagagaataagaagtccaagggacgccgtcagccttta
agcaagctcccccgccatcacccacttgtgctgcaggagtgtgtcagtgatgatgagaca
tctgaacagctgacccctgaggaagaggctgaggagacagaggcctgggccaagcctctg
agccaactgtggcagaaccgacctccaaactttgaggctgagaaggaattcaatgagacc
atggcccaacaggcccctcactgcgctgtctgtatgatcttccagacttatcatcaggtt
gaatttggaggctttaatcagaactgtggaaatgcttcagatttagccccccagaagcag
aggaccaagccattgattccagaaatgtgcttcacttcgactggctgcagcacggacatc
aacctttctactccttatcttgaggaggatggcaccagcatactcgtttcctgcaagaag
tgcagcgtccgggtccatgccagttgctatggggtcccccctgcaaaggcttctgaagac
tggatgtgttctcggtgttcagccaatgccctagaggaggactgctgtttatgctcatta
cgaggaggggccctgcagagagcaaatgatgacaggtgggtccacgtttcatgtgctgtg
gcaattctggaagcaaggtttgtcaacattgcagaaagaagtccggtggatgtgagcaaa
atccccctgccccgcttcaaactgaaatgtatcttctgtaagaagcggaggaaaagaact
gctggctgctgtgtgcagtgttctcacggccgctgcccaactgccttccatgtgagctgc
gcccaggctgccggtgtgatgatgcagcctgacgactggccttttgtggtcttcattacc
tgctttcggcacaagattcctaatttggagcgtgccaagggggccttgcaaagcatcact
gcaggccagaaagtcattagcaagcataagaacgggcgcttctaccagtgtgaagtggtc
aggctcaccaccgagaccttctatgaagtcaactttgatgatggctccttcagcgacaat
ctttatcctgaggacatagtgagccaggactgtctccagtttggtcctcctgctgaaggg
gaagtggtccaagtgagatggacagacggccaagtctatggagccaagtttgtggcctcc
caccctatccaaatgtaccaggtggagtttgaggatggctcacaacttgtggttaagaga
gatgatgtatacacactggatgaagagcttcccaagagagtcaaatctagactgtcagta
gcctcagacatgcgcttcaatgagattttcacagagaaagaggttaagcaagaaaagaaa
cggcaacgagttatcaactcaagataccgggaagattatattgagcctgcactataccgg
gccatcatggagtag

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Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   RefSeq(nuc) (1)   
   GenBank (9)   
   EMBL (9)   
3D Structure (85)   
   PDB (85)   
Protein domain (11)   
   Pfam (11)   
All databases (147)   

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