KEGG   Homo sapiens (human): 9690
Entry
9690              CDS       T01001                                 
Symbol
UBE3C, HECTH2, NDSMBA, NEDSMBA, RAUL
Name
(RefSeq) ubiquitin protein ligase E3C
  KO
K10589  ubiquitin-protein ligase E3 C [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Disease
H02715  Neurodevelopmental disorder with defects of ubiquitin-proteasome system
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    9690 (UBE3C)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    9690 (UBE3C)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     9690 (UBE3C)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   9690 (UBE3C)
SSDB
Motif
Pfam: HECT IQ
Other DBs
NCBI-GeneID: 9690
NCBI-ProteinID: NP_055486
OMIM: 614454
HGNC: 16803
Ensembl: ENSG00000009335
UniProt: Q15386
Structure
Position
7:157138926..157269370
AA seq 1083 aa
MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYR
DRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQN
LIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENT
YLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLEN
VLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNA
LLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASAS
CHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEE
VFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQ
VISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLE
ELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQ
LFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIG
PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFL
DGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNEL
LKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA
GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVV
ELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEI
QVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSR
PPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF
ELS
NT seq 3252 nt   +upstreamnt  +downstreamnt
atgttcagcttcgaaggcgacttcaagacgcggcccaaggtgtcccttggcggcgcgagc
aggaaggaggaaaaggcttctcttttacatcgtactcaggaagaaagaagaaagagagag
gaagaaaggcgaaggttgaaaaatgcaataattatccagtcatttattcgaggctataga
gacagaaaacagcaatattccatccaaagaagtgcatttgatcgctgtgctaccttgtca
cagtccgggggcgcttttcccattgctaatggccccaaccttacccttttggtaaggcag
cttctgtttttttacaaacaaaatgaagactcaaaacgtttgatatggctgtatcagaac
ttaattaaacacagctctctgtttgtcaagcagttggatggatctgagagacttacatgc
ttatttcagataaaaagattgatgagcctctgttgcaggttgctgcaaaactgtaatgat
gacagtttgaatgttgcacttccaatgagaatgcttgaagtattttcgtctgagaatact
tacttgcctgttttacaagatgctagctatgtggtgtcagtgattgaacaaattttgcac
tacatgattcacaatgggtattataggtctctatatttgttgattaacagcaagcttcca
tcaagtattgaatattctgatttatctcgagttcctatagcaaaaattttgctagagaat
gttctaaaaccattgcactttacttacaactcctgtccggaaggtgcgaggcaacaagtt
tttacagccttcacagaggagtttctggcagcaccttttacagatcagatttttcatttc
atcattccggcgcttgcagatgcgcagaccgttttcccttacgagccctttctgaatgca
ctgttgttaatagagagtagatgttcaagaaagagtggtggagcaccctggcttttctat
ttcgttttaactgttggcgaaaattatttgggggccctctctgaggaagggctgctggtg
tatttgcgggtgctgcagaccttcctctctcagttaccagtctctcctgccagcgcgagc
tgtcacgactcagccagtgactctgaggaggagagtgaagaagccgacaagccctcaagc
ccggaggatggcagactgtcagtatcatacataacagaggaatgcctgaagaagctggac
acaaagcagcagaccaacaccctgctcaacctggtgtggagggactctgcgagcgaggag
gtcttcaccaccatggcctccgtctgccacacgctgatggtgcagcaccgcatgatggta
cccaaagtcaggcttctctacagtttagcctttaatgccaggtttctgagacatctttgg
tttctaatatcttccatgtcaacacggatgatcacagggtctatggtaccgttgcttcag
gtgatatccaggggttctcctatgtcttttgaagattctagtcgaatcatcccactcttt
tatctttttagctccttgtttagtcattcactaatttccatacatgataacgaattcttc
ggtgatcccatagaagttgtaggtcaaagacaatcatcaatgatgccttttactttagaa
gagctgataatgttgtctcgatgccttcgagatgcatgcctggggatcatcaagttggct
tatccagaaaccaagccagaagttcgagaagaatatattacagcatttcagagtattgga
gttactactagctctgaaatgcaacaatgcatacagatggaacagaaaagatggattcag
ttatttaaggttatcaccaatctagtgaaaatgttgaagtccagagacacgaggagaaat
ttttgtcctccaaaccactggctgtcagaacaagaagatattaaagcagataaggtcact
cagctctatgtgccagcatccagacatgtgtggaggttccggcggatggggaggataggc
ccgctgcagtccaccctggacgtgggtttggagtccccgccgctgtctgtgtctgaggaa
agacagcttgctgtcctgacagagttgccttttgtggttccatttgaggaacgagtaaag
atctttcagaggttgatttatgcagataagcaagaagttcaaggagatggtccatttctg
gatggaattaatgtcacaataagaagaaattacatttatgaagatgcttatgacaaactt
tctccagaaaatgagcctgatttgaaaaagcggatccgtgtgcacttgctcaatgcccat
ggcctggatgaagctggcattgatggtggtggtattttcagagagtttttaaatgaacta
ctgaagtcaggatttaaccccaaccaggggttctttaagactactaatgaagggcttctg
taccccaacccggctgctcagatgcttgtgggagattcttttgccagacattactacttc
ctaggcagaatgcttggaaaggctctctatgagaacatgctggtggagctgccctttgca
ggcttctttctttccaagttgcttggaaccagtgccgacgtggacattcaccacctcgcc
tccctagaccctgaggtgtataagaatttgctctttctgaagagctacgaagacgatgtg
gaggagcttgggctgaacttcactgtggtgaacaatgacctgggagaggcgcaggtagtt
gaactaaaattcggtgggaaagacatccctgtcaccagcgccaaccggattgcgtacatc
cacttggtggcagactacaggctgaacaggcagatccgccagcactgcctggctttccgc
cagggccttgccaatgtcgtcagcctcgagtggctccgaatgtttgatcagcaagaaatt
caggtattaatttctggtgcacaagttcccataagcctagaggacctaaaatcctttaca
aactattcaggaggctattctgcagaccatcctgttattaaggtcttctggagagttgtg
gaagggttcactgatgaagaaaagcgcaaactgctgaagtttgtaacaagctgctctcga
ccccctctcttggggtttaaggagttgtatcccgcattttgtattcacaacggaggctcc
gaccttgagcggctccccacagccagcacctgcatgaacctgctgaagctccccgagttc
tatgacgagacacttttgcgaagtaaacttctctatgcgattgaatgtgccgctggcttt
gagctgagctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (25)   
   RefSeq(nuc) (7)   
   GenBank (9)   
   EMBL (9)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (61)   

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