KEGG   Homo sapiens (human): 9706
Entry
9706              CDS       T01001                                 
Symbol
ULK2, ATG1B, Unc51.2
Name
(RefSeq) unc-51 like autophagy activating kinase 2
  KO
K08269  serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04136  Autophagy - other
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa05010  Alzheimer disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    9706 (ULK2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    9706 (ULK2)
   04136 Autophagy - other
    9706 (ULK2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    9706 (ULK2)
   05014 Amyotrophic lateral sclerosis
    9706 (ULK2)
   05016 Huntington disease
    9706 (ULK2)
   05017 Spinocerebellar ataxia
    9706 (ULK2)
   05022 Pathways of neurodegeneration - multiple diseases
    9706 (ULK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    9706 (ULK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9706 (ULK2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    9706 (ULK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     9706 (ULK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  ULK family [OT]
   9706 (ULK2)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Autophagosome formation proteins
   Atg1 complex
    9706 (ULK2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-independent mechanism factors
    9706 (ULK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ATG1-like_MIT2 ATG1-like_MIT1 Kdo ABC1 RIO1 Pkinase_fungal Kinase-like TcdA_TcdB
Other DBs
NCBI-GeneID: 9706
NCBI-ProteinID: NP_001136082
OMIM: 608650
HGNC: 13480
Ensembl: ENSG00000083290
UniProt: Q8IYT8
Structure
Position
17:complement(19770830..19867936)
AA seq 1036 aa
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKIL
KELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMR
ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY
MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRET
SPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSP
SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI
SSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTST
ASSGTNVHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPL
VGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQSPQSLLSGARLQSAPTLTDIYQNKQ
KLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGS
PTKTTAPFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQS
KAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTERPMDIAPAGACGGVLAPPAGTAASS
KAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSS
PPGAEAAPSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECV
LDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLH
LAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVT
AEKLIYNCAVEMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKC
SIERRLSALCHSTATV
NT seq 3111 nt   +upstreamnt  +downstreamnt
atggaggtggtgggtgacttcgagtacagcaagagggatctcgtgggacacggggccttc
gccgtggtcttccgggggcggcaccgccagaaaactgattgggaggtagctattaaaagt
attaataaaaagaacttgtcaaaatcacaaatactgcttggaaaggaaattaaaatctta
aaggaacttcagcatgaaaatattgtagcactctatgatgttcaggaattacccaactct
gtctttttggtgatggagtattgcaatggtggagacctcgcagattatttgcaagcgaaa
gggactctcagtgaagacacgatcagagtgtttctgcatcagattgctgctgccatgcga
atcctgcacagcaaaggaatcatccacagagatctcaaaccacagaacatcttgctgtcc
tatgccaatcgcagaaaatcaagtgtcagtggtattcgcatcaaaatagcggattttggt
tttgctcgttacctacatagtaacatgatggctgcaacactgtgtggatccccgatgtac
atggctcctgaggttattatgtctcaacattatgatgctaaggctgacttgtggagcata
ggaacagtgatataccaatgcctagttggaaaaccaccttttcaggccaatagtcctcaa
gacttaaggatgttttatgaaaaaaacaggagcttaatgcctagtattcccagagaaaca
tcaccttatttggctaatctccttttgggtttgcttcagagaaaccaaaaagatagaatg
gactttgaagcattttttagccatccttttcttgagcaaggtccagtaaaaaaatcttgc
ccagttccagtgcccatgtattctggttctgtctctggaagctcctgtggcagctctcca
tcttgtcgttttgcttctccaccatcccttccagatatgcagcatattcaggaagaaaac
ttatcttccccaccattgggtcctcccaactatctacaagtttccaaagattctgccagt
actagtagcaagaactcttcttgtgacacggatgactttgttttggtgccacacaacatc
tcgtcagaccactcatgtgatatgccagtggggactgctggcagacgtgcttcaaatgaa
ttcttggtgtgtggagggcagtgtcagcctactgtgtcacctcacagcgaaacagcacca
attccagttcctactcaaataaggaattatcagcgcatagagcagaatcttacatctact
gccagctcaggcacaaatgtacatggttctccaagatctgcagtggtacgaaggtccaac
accagccccatgggcttcctccggccgggatcatgctccccagtaccagcagacacagca
cagacagttggacgaaggctctccactgggtcttctaggccttactcaccttcccctttg
gttggtaccattcctgagcaattcagtcagtgctgctgtgggcatcctcagggccatgac
tccaggagtagaaactcctcaggttctccagtgccacaagctcagtccccacagtctctc
ttatcgggtgctagactgcagagcgcccccaccctcactgacatctatcagaacaagcag
aagctcagaaaacagcactctgaccccgtgtgcccatcccatactggggctgggtacagc
tactcgcctcagcccagtcggcctggcagccttggaacttctcccaccaagcacttgggg
tcctctccacggagttctgactggttctttaaaactcctttgccaacaatcattggctct
cctactaagaccacagctcctttcaaaatccctaaaactcaagcatcttccaacctgtta
gccttggttactcgtcatgggcctgctgaagaacagtcgaaagatgggaatgagccacgg
gaatgtgcccattgcctcttagtgcaaggaagtgagaggcagcgggccgagcagcagagc
aaggcagtgtttggcagatctgtcagtaccgggaagttatcagatcaacaaggaaagact
cctatatgtcgacatcagggcagcacagacagtttaaatacagaacgaccaatggatata
gctccggcaggagcctgtggtggtgttctggcacctcctgcaggtacagcagcaagttcc
aaggctgtcctcttcactgtagggtctcctccacacagtgcggcagcccccacttgtacc
cacatgttccttcgaacaagaacaacctcagtggggcccagcaactccgggggctctctt
tgtgccatgagtggccgcgtgtgcgtggggtccccgcctggcccaggcttcggctcttcc
cctccaggagcagaggcagctcccagcctgagatacgtgccttacggtgcttcacccccc
agcctagaggggctcatcacctttgaagcccctgaactgccggaggagacgctgatggag
cgggaacacacagacaccttacgccatctgaatgtgatgctgatgttcactgagtgtgtg
ctggacctgacagccatgaggggaggaaaccctgagctgtgcacatctgctgtgtccttg
taccagatccaggagagtgtggtggtggaccagatcagtcagctgagcaaagactggggg
cgggtggagcagctggtgttgtacatgaaagcagcacagctgcttgcggcttctctgcat
cttgccaaagcccagatcaagtccgggaaactgagcccatccacagctgtgaaacaagtt
gtcaagaatctgaacgaacgatataaattctgcatcaccatgtgcaagaaacttacagaa
aagctgaatcgattcttctctgacaaacagaggtttattgatgaaatcaacagtgtgact
gcagagaaactcatctataattgtgctgtagaaatggttcagtctgcagccctggatgag
atgtttcagcagaccgaagatattgtttatcgctatcataaggcagcccttcttttggaa
ggcctaagtaggattctacaggaccctgcagatattgaaaatgtgcataaatataaatgt
agtattgagagaagactgtcggcgctctgccatagcaccgcaaccgtgtga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (8)   
   KEGG PATHWAY (8)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (22)   
   RefSeq(nuc) (8)   
   GenBank (7)   
   EMBL (7)   
3D Structure (4)   
   PDB (4)   
Protein domain (10)   
   Pfam (10)   
All databases (89)   

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