| Entry |
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| Name |
saccharopine dehydrogenase (NAD+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming);
epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming);
N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming);
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
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| Reaction(IUBMB) |
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ [RN: R00715]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| History |
EC 1.5.1.7 created 1972
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K00290 | saccharopine dehydrogenase (NAD+, L-lysine forming) |
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| Genes |
| ATEN: | 116297853 116298760 116300891 116300965 |
| PDAM: | 113665974 113665975 |
| SPIS: | 111333439 111333523 111335282 111337694 |
| NCS: | NCAS_0A08650(NCAS0A08650) |
| NDI: | NDAI_0G05090(NDAI0G05090) |
| TPF: | TPHA_0N01860(TPHA0N01860) |
| TBL: | TBLA_0C01000(TBLA0C01000) |
| TDL: | TDEL_0B07590(TDEL0B07590) |
| KAF: | KAFR_0A00160(KAFR0A00160) |
| KNG: | KNAG_0H00170(KNAG0H00170) KNAG_0M02400(KNAG0M02400) |
| SPAA: | SPAPADRAFT_147229(LYS1) |
| LEL: | PVL30_004380(LYS1_2) |
| CAL: | CAALFM_C405320WA(LYS1) |
| CTEN: | CANTEDRAFT_113510 CANTEDRAFT_115850 |
| NTE: | NEUTE1DRAFT91293(NEUTE1DRAFT_91293) |
| FVR: | FVEG_11605 FVEG_16154 |
| FMU: | J7337_010011 J7337_010372 |
| BFU: | BCIN_05g04270(Bclys1) |
| PSCO: | LY89DRAFT_604497 LY89DRAFT_651629 |
| ALUC: | AKAW2_10619A(LYS1_1) |
| ACHE: | ACHE_21163A(LYS1_2) |
| APUU: | APUU_30693A(LYS1_2) |
| CCAC: | CcaHIS019_0608570(LYS1) |
| ABP: | AGABI1DRAFT96692(AGABI1DRAFT_96692) |
| ABV: | AGABI2DRAFT133180(AGABI2DRAFT_133180) |
| SCM: | SCHCO_02612998(SCHCODRAFT_02612998) |
| RMM: | ROSMUCSMR3_00818(ald) |
| MALU: | KU6B_07830 KU6B_07840 |
| LVS: | LOKVESSMR4R_03787(ald) |
| HAX: | BALOs_2120 BALOs_2686 |
| SGM: | GCM10017557_34240(sdh) |
| SLX: | SLAV_08715 SLAV_39975 |
| STUI: | GCM10017668_59820(sdh) |
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| Reference |
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| Authors |
Fujioka M, Nakatani Y. |
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| Title |
Saccharopine dehydrogenase. Interaction with substrate analogues. |
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| Journal |
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| Reference |
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| Authors |
Saunders PP, Broquist HP |
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| Title |
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase. |
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| Journal |
J Biol Chem 241:3435-40 (1966) |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.1.7 |
| ExPASy - ENZYME nomenclature database: | 1.5.1.7 |
| BRENDA, the Enzyme Database: | 1.5.1.7 |
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