PMID:
20102775
Authors:
Deluis DA, Sagrado MG, Aller R, Izaola O, Conde R.
Title:
Effects of C358A missense polymorphism of the degrading enzyme fatty acid amide
hydrolase on weight loss, adipocytokines, and insulin resistance after 2
hypocaloric diets.
Journal:
Metabolism. 2010 Sep;59(9):1387-92. doi: 10.1016/j.metabol.2009.12.029. Epub 2010
Abstract:
It has been demonstrated that the polymorphism 385 C/A of fatty acid amide
hydrolase was associated with obesity. We decided to investigate the role of a
polymorphism (cDNA 385 C->A) on insulin resistance and weight loss secondary to a
low-fat vs a low-carbohydrate diet. A population of 248 patients with obesity was
analyzed. Basal measurements were performed, and values were compared to those at
the end of a 3-month period in which subjects received either diet I (low fat) or
diet II (low carbohydrate). One hundred seventy-eight patients (71.8%) had the
genotype C358C (wild-type group), and 70 (28.2%) patients had the genotype C358A
(62 patients, 25%) or A358A (8 patients, 3.2%) (mutant-type group). With diet I,
body mass index, weight, fat mass, waist circumference, and systolic blood
pressures decreased in the wild-type and mutant-type groups. With diet II, body
mass index, weight, fat mass, waist circumference, and systolic blood pressures
decreased in both genotypes. With diet I, leptin, glucose, total cholesterol,
triglyceride, insulin, and homeostasis model assessment for insulin sensitivity
(HOMA) decreased in the wild-type group. In the mutant-type group, only
cholesterol decreased in a significant way. With diet II, leptin, interleukin-6,
glucose, total cholesterol, low-density lipoprotein cholesterol, insulin, HOMA,
and C-reactive protein decreased in the wild-type genotype. The allele A358 of
fatty acid amide hydrolase was associated with a lack of improvement on glucose
insulin, HOMA, and leptin levels in both diets after weight loss.
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