PMID:
     20402571
Authors:
     Parks RW, Thiyagesh SN, Farrow TF, Ingram L, Wilkinson K, Hunter MD,
     Wilkinson ID, Young C, Woodruff PW.
Title:
     Performance on the clock drawing task correlates with FMRI response to a 
     visuospatial task in Alzheimer's disease.
Journal:
     Int J Neurosci. 2010 May;120(5):335-43. doi: 10.3109/00207450903320339.
Abstract:
     The clock drawing (CD) task involves visual integration skills associated with 
     parietal lobe function. Seven mild Alzheimer's Disease (AD) patients and 11 
     healthy elderly controls (EC) underwent functional magnetic resonance imaging 
     (fMRI) scanning while viewing a radial motion (RM) task. This RM task in EC 
     activated the bilateral secondary visual cortex and parietal regions, whereas AD 
     patients activated only the right-sided secondary visual cortex. The magnitude of 
     the fMRI signal in the left superior parietal lobe was positively correlated with 
     performance on the CD task in AD patients. These findings suggest that complex 
     visuospatial processing impairments reflect the underlying AD neuropathology in 
     parietal regions.

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