PMID:
     20545561
Authors:
     Flynn MM, Reinert SE.
Title:
     Comparing an olive oil-enriched diet to a standard lower-fat diet for weight loss 
     in breast cancer survivors: a pilot study.
Journal:
     J Womens Health (Larchmt). 2010 Jun;19(6):1155-61. doi: 10.1089/jwh.2009.1759.
Abstract:
     BACKGROUND: Traditional diets that include moderate to high intakes of extra 
     virgin olive oil have been related to a decrease in breast cancer risk. We 
     hypothesized that an olive oil-enriched diet would lead to greater weight loss 
     and acceptance, compared with a standard diet, in women previously diagnosed with 
     invasive breast cancer. METHODS: Participants consumed a National Cancer 
     Institute (NCI) diet (total fat > 15% and < 30%) and a plant-based olive oil diet 
     (PBOO; > or = 3 tablespoons of olive oil/day) for 8 weeks, each with random 
     assignment to the order. We established a weight loss goal of at least 5% of 
     baseline weight. After completion of the two diet trials, each participant 
     self-selected one of the diets for an additional 6 months of follow-up for weight 
     management. Body measures were done before and after each diet and after 
     follow-up; fasting blood samples were collected after each diet and after 
     follow-up. RESULTS: Forty-four overweight women started and 28 completed the 
     44-week protocol. Twelve (80%) of the 15 women who started with the PBOO diet 
     achieved a weight loss of > or = 5% compared to 4 (31%) of the 13 who started 
     with the NCI diet (p < 0.01). Nineteen of the 22 women eligible for follow-up 
     chose the PBOO diet, and all completed the study. Of the 3 women who chose the 
     NCI diet for follow-up, 1 completed the study. The PBOO diet resulted in lower 
     triglycerides (NCI 105 +/- 46 mg/dL, PBOO 96 +/- 37 mg/dL, p = 0.06) and higher 
     high-density lipoprotein cholesterol (HDL-C) (NCI 64 +/- 13 mg/dL, PBOO 68 +/- 12 
     mg/dL, p = 0.001). CONCLUSIONS: An olive oil-enriched diet brought about greater 
     weight loss than a lower-fat diet in an 8-week comparison. Moreover, these women 
     chose, overwhelmingly, the olive oil-enriched diet for 6 months of follow-up. An 
     olive oil-enriched diet may be more efficacious for weight loss in breast cancer 
     survivors than a standard lower-fat diet.

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