GenomeNet

Database: PubMed
Entry: 21576145
LinkDB: 21576145
Original site: 21576145 
PMID:
     21576145
Authors:
     Mora MS, Nestoriuc Y, Rief W.
Title:
     Lessons learned from placebo groups in antidepressant trials.
Journal:
     Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1879-88. doi: 
Abstract:
     This comprehensive review provides an overview about placebo and nocebo phenomena 
     in antidepressant trials. Improvements in the placebo groups may partly be 
     explained through methodological issues such as natural course of depression and 
     regression to the mean, but also fundamentally reflect investigators' and 
     participants' expectations. A meta-analysis by our group of 96 randomized 
     placebo-controlled trials showed large placebo responses to antidepressant 
     medication. Moderator analyses revealed substantially larger placebo responses in 
     observer ratings compared with self-report. Effect sizes in observer ratings 
     showed strong increase with publication year while this effect was not found for 
     patients' self-ratings. This reflects the strong influence of investigators' 
     expectations. The analysis of 'nocebo effects', e.g. adverse effects in placebo 
     groups of antidepressant trials also confirms the impact of expectations: nocebo 
     symptoms reflected the typical side-effect patterns expected in the drug group, 
     with higher symptoms rates in the placebo groups of tricyclic antidepressant 
     trials compared with placebo groups of trials testing selective serotonin 
     reuptake inhibitors. While the placebo response seems to be similar for women and 
     men, gender differences were found for nocebo rates. In the conclusion, we 
     discuss potential implications for clinical trial designs and argue for 
     interventions aimed at optimizing positive expectations of treatment benefit 
     while minimizing the impact of adverse effects.

This page is constructed based on the NCBI service.
  All links  
No link information was found.   
DBGET integrated database retrieval system