KEGG   Mus musculus (house mouse): 100043456
Entry
100043456         CDS       T01002                                 
Symbol
Hsd3b8, Gm10681, Hsd3b4
Name
(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 8
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00140  Steroid hormone biosynthesis
mmu01100  Metabolic pathways
mmu04913  Ovarian steroidogenesis
mmu04925  Aldosterone synthesis and secretion
mmu04927  Cortisol synthesis and secretion
mmu04934  Cushing syndrome
Module
mmu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mmu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mmu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mmu_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100043456 (Hsd3b8)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100043456 (Hsd3b8)
   04925 Aldosterone synthesis and secretion
    100043456 (Hsd3b8)
   04927 Cortisol synthesis and secretion
    100043456 (Hsd3b8)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100043456 (Hsd3b8)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100043456 (Hsd3b8)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100043456 (Hsd3b8)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 NAD_binding_10 GDP_Man_Dehyd NmrA Polysacc_synt_2 RmlD_sub_bind KR Semialdhyde_dh Ldh_1_N
Other DBs
NCBI-GeneID: 100043456
NCBI-ProteinID: NP_001257358
MGI: 3711284
Ensembl: ENSMUSG00000095388
UniProt: Q61767 Q3UIU9
Position
3:complement(98459858..98471366)
AA seq 373 aa
MPGWSCLVTGAGGFLGQRIVRMLVQEEELQEIRALFRTFGRKQEEELSKLQTKTKVTVLK
GDILDAQCLKRACQGMSAVIHTAAAIDPLGAASRQTILDVNLKGTQLLLDACVEANVPTF
IYSSSVLVAGPNSYKEIILNAHEEEHHESTWSNPYPYSKKMAEKAVLAANGSILKNGGTL
HTCALRLSFIYGEECQVTSTTVKTALKNNSIIKKNATFSIANPVYVGNAAWAHILAARSL
QDPKKSPSIQGQFYYITDDTPHQSYDDLKCTLSKEWGLRLDTSWSLPLPLLYWLAFLLET
VSFLLRPVYNYRPPFNRLLITVLNSVFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTL
VMQHREIGNKKSQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgcctgggtggagctgcctggtgacaggagcaggagggtttcttggccagaggattgtc
cgaatgttggtgcaggaggaagagctgcaggagatcagagccctgttcaggaccttcggt
cgaaaacaggaagaggaattgtccaagctgcagacaaagaccaaggtgacagtactgaag
ggagacattctggatgcccagtgcctgaagagagcctgccagggcatgtctgctgtcatc
cacaccgctgctgctattgacccccttggtgccgcttccagacagaccatcctagatgtc
aatctgaaaggtactcagctcctactggatgcttgtgtggaagccaacgtgccaacattc
atctacagcagctcagtgcttgtggctggaccaaattcctacaaggagatcatcctgaat
gcccatgaggaggagcatcatgaaagcacatggtctaacccatacccatacagcaaaaag
atggctgagaaggcagtgctggcagccaatgggagcatcctgaaaaatggtggcactttg
catacttgtgccttaagactctctttcatctatggggaagaatgccaagtcacttcaacc
actgtgaaaacagcactgaagaacaacagcataattaagaaaaatgccacattctccatc
gccaacccagtgtatgtgggcaatgcagcctgggctcacattctggctgccaggagccta
caggaccctaagaagtccccaagcatccaaggacagttctattacattacagatgacacc
cctcaccaaagctatgatgacttaaaatgcaccctgagcaaggagtggggcctccgcctt
gataccagctggagtcttcctctgcccctgctctactggcttgccttcctcctggaaact
gtgagcttcctgctacgtccagtctacaactatagaccaccatttaaccgcctcttgatc
acagtgctaaatagtgtattcaccttctcctacaagaaggctcagcgagatctgggctat
gagccacttgtcagctgggaggaagccaagcagaaaacctcagagtggatcggaacacta
gtgatgcagcacagggagattggaaacaaaaagtcacagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (13)   
   RefSeq(nuc) (3)   
   GenBank (5)   
   EMBL (5)   
Protein domain (11)   
   Pfam (11)   
All databases (79)   

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