KEGG   Mus musculus (house mouse): 108156
Entry
108156            CDS       T01002                                 
Symbol
Mthfd1, Dcs, E430024A07Rik, Mthfd
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00670  One carbon pool by folate
mmu01100  Metabolic pathways
mmu01240  Biosynthesis of cofactors
Module
mmu_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    108156 (Mthfd1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    108156 (Mthfd1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     108156 (Mthfd1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     108156 (Mthfd1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     108156 (Mthfd1)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   108156 (Mthfd1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 108156
NCBI-ProteinID: NP_620084
MGI: 1342005
Ensembl: ENSMUSG00000021048
UniProt: Q922D8 Q8BXX7 Q3TW74
Position
12:76301180..76366594
AA seq 935 aa
MAPAGILNGKLVSAQIRDRLKNQVTRMQEQVPGFTPGLAILQVGDRDDSNLYINVKLKAA
EEIGIKATHIKLPRTSTESEVLKYVISLNEDASVHGFIVQLPLDSENSINTEAVINAIAP
EKDVDGLTSVSAGKLARGDLNDCFIPCTPKGCLELIKEAGVQIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTANLDKEVNKGDILVVATGQPEMVKGEWIKPGAVVIDCGINY
VPDDTKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAQRFLQKFKP
GKWTIQYNKLNLKTPVPSDIAISRSCKPKLIGNLAREIGLLTEEVELYGETKAKVLLSAL
DRLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLRQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGIRKFSDIQIRRLRRLGIEKTDPTTLTDDEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQSPTEKGHTRTAQFDISVASEIMAVLALTSSLEDMRERLGRMVVASSKKGEPI
SCEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLQPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYTEEDLDLVEKGFSNLRKQIENARMFGVPVVVAVNVFKTDTDAELDLVSRLSREHGAF
DAVKCTHWAEGGQGALALAQAVQRASQAPSSFQLLYDLKLSIEDKIRIIAQRIYGADDIE
LLPEAQNKAEIYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFVLPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcaccagcgggaatcctgaacgggaaactggtttctgcgcaaatcagggatcgactg
aagaaccaggtaactcggatgcaggagcaggtacctggcttcacccctggcctggcaatc
ctgcaggttggcgacagagatgattccaatctttatataaatgtgaagctgaaggctgct
gaagagattgggatcaaagccactcacattaaattaccaagaacatccacagagtccgag
gtgttaaaatatgtcatctccctgaacgaggatgcctctgtgcacggattcatagtgcag
ctgcctttagattcagagaattccattaacactgaggcagtcatcaatgccattgcaccc
gagaaggatgtggatgggttgacgagcgtcagtgctgggaagctcgccagaggtgatcta
aatgactgcttcatcccatgcacacccaagggatgcttggaactcatcaaagaggcaggg
gtgcagattgccggaaggcacgcggtggtggttggtcgaagtaagatagttggtgcaccc
atgcatgacctccttctgtggaacaatgccacggtgaccacctgccactccaagactgcc
aatctggacaaggaggtaaataaaggagacattctggtggttgccacaggccagcctgag
atggtgaagggggagtggatcaagcctggggctgtggtcatagactgtgggatcaattat
gttccagatgatacaaaaccaaatggaaggaaagtcgtgggtgatgtggcctacgatgag
gccaaggagagggcgagctttatcacgcctgtccctggtggcgtggggcccatgaccgtg
gcaatgctgatgcagagcacagtagagagcgcacagcgcttcctacagaaatttaagcca
gggaagtggacaattcagtataacaagctgaacctcaagactcctgtcccaagtgacatt
gctatatcacgatcttgcaaaccaaagctcatcgggaacctggcccgagaaatcgggctg
ctcaccgaagaggtggagttgtacggggaaacgaaggctaaagtcttgctgtcagcatta
gatcgcctgaagcatcagccagatgggaaatatgtcgtggtgactggaattactccaaca
ccgctgggagaagggaagagtaccaccacgatcgggctggtgcaggccctcggcgcccac
ctgcgacagaacgtctttgcatgtgtgcgacagccttcgcagggccccacctttgggata
aaaggtggcgctgcaggaggcggctattcccaggtcattcctatggaagagtttaacctc
cacctcactggtgacatccacgccatcactgctgctaacaacctcgtggctgctgccatt
gatgctcggatatttcatgagctgacccagacagacaaggctctctttaatcgtctggta
ccttcagtaaacggaataagaaaattctctgacatccaaatccgcaggttacggaggcta
ggcattgagaagactgaccccaccacgctgacagatgacgagataaacagatttgcaaga
ctggatattgacccagaaaccataacatggcagagagtgttggacaccaacgatagattc
ctgaggaagatcacaattggacagtctccaacagagaaaggccacacacgcacggcccag
tttgatatctctgtggccagtgagatcatggcagtcctggccctcacgagctctctggaa
gacatgagagagagactgggcagaatggtggtagcgtccagtaagaaaggggagcctatc
agttgcgaagacctgggcgtgagtggggcgctgacggtgctgatgaaggatgcaatcaag
cccaacctcatgcagaccttagagggcacgccagtgtttgtccatgccgggcctttcgcc
aacattgcacacgggaattcctccatcattgcagaccggattgcactcaagctggtaggc
cctgagggcttcgtagtaacggaagctggattcggagcagacataggaatggaaaagttc
ttcaacatcaagtgccggtattctggtctccagccacacgtggtggttctggttgccact
gtcagggcccttaagatgcacgggggtggccccacggtcaccgctggactgcctcttccc
aaggcttacacagaagaggacctggacctggttgaaaagggcttcagtaacttgaggaaa
caaatcgaaaatgctagaatgtttggagtccctgtcgtcgtggctgtgaacgtgttcaag
acagatacagatgctgagctggaccttgtcagccgcctctccagagaacacggggctttt
gatgctgtcaagtgcacccactgggcagaagggggccagggggccttggccctggctcag
gctgtccagagagcgtcacaggcccccagcagcttccagctcctctatgacctcaagctc
tcaattgaggataaaatcaggattattgcacagaggatctacggggccgatgacatcgaa
ttgctcccggaagcacagaacaaagcagaaatttacacaaagcagggctttgggaatcta
cccatctgcatggccaaaacacacttgtccttgtctcacaacccagagcaaaaaggggtg
cctactggtttcgttctgcccatccgggacatccgtgccagcgttggggcaggtttcctg
tatcctttagtaggaacgatgagcacaatgcctggactccctacgcggccctgtttttat
gatattgatttggatcctgaaacggaacaagtgaatggattgttttaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (62)   
   RefSeq(nuc) (2)   
   GenBank (30)   
   EMBL (30)   
Protein domain (3)   
   Pfam (3)   
All databases (114)   

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