KEGG   Mus musculus (house mouse): 11480
Entry
11480             CDS       T01002                                 
Symbol
Acvr2a, ActrIIa, Acvr2, TactrII
Name
(RefSeq) activin receptor IIA
  KO
K04670  activin receptor type-2A [EC:2.7.11.30]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04060  Cytokine-cytokine receptor interaction
mmu04350  TGF-beta signaling pathway
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    11480 (Acvr2a)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    11480 (Acvr2a)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    11480 (Acvr2a)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    11480 (Acvr2a)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    11480 (Acvr2a)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     11480 (Acvr2a)
Protein kinases [BR:mmu01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   11480 (Acvr2a)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Activin_recp FTA2
Other DBs
NCBI-GeneID: 11480
NCBI-ProteinID: NP_031422
MGI: 102806
Ensembl: ENSMUSG00000052155
UniProt: P27038 Q8BRV4 A2AI38
Structure
Position
2:48704121..48793276
AA seq 513 aa
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHC
FATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEM
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
NT seq 1542 nt   +upstreamnt  +downstreamnt
atgggagctgctgcaaagttggcgttcgccgtctttcttatctcttgctcttcaggtgct
atacttggcagatcagaaactcaggagtgtcttttctttaatgctaattgggaaagagac
agaaccaaccagactggtgttgaaccttgctatggtgataaagataaacggcgacattgt
tttgctacctggaagaatatttctggttccattgaaatagtgaagcaaggttgttggctg
gatgatatcaactgctatgacaggactgattgtatagaaaaaaaagacagccctgaagtg
tacttttgttgctgtgagggcaatatgtgtaatgaaaagttctcttattttccggagatg
gaagtcacacagcccacttcaaatcctgttacaccgaagccaccctattacaacattctg
ctgtattccttggtaccactaatgttaattgcaggaattgtcatttgtgcattttgggtg
tacagacatcacaagatggcctaccctcctgtacttgttcctactcaagacccaggacca
cccccaccttccccattactagggttgaagccattgcagctgttagaagtgaaagcaagg
ggaagatttggttgtgtctggaaagcccagttgctcaatgaatatgtggctgtcaaaata
tttccaatacaggacaaacagtcctggcagaatgaatatgaagtctatagtctacctgga
atgaagcatgagaacatactacagttcattggtgcagagaaaagaggcaccagtgtggat
gtggacctgtggctaatcacagcatttcatgaaaagggctcactgtcagactttcttaag
gctaatgtggtctcttggaatgaactttgtcatattgcagaaaccatggctagaggattg
gcatatttacatgaggatatacctggcttaaaagatggccacaagcctgcaatctctcac
agggacatcaaaagtaaaaatgtgctgttgaaaaacaatctgacagcttgcattgctgac
tttgggttggccttaaagttcgaggctggcaagtctgcaggtgacacccatgggcaggtt
ggtacccggaggtatatggctccagaggtgttggagggtgctataaacttccaaagggac
gcatttctgaggatagatatgtacgccatgggattagtcctatgggaattggcttctcgt
tgcactgctgcagatggacccgtagatgagtacatgttaccatttgaggaagaaattggc
cagcatccatctcttgaagatatgcaggaagttgttgtgcataaaaaaaagaggcctgtt
ttaagagattattggcagaaacatgcaggaatggcaatgctctgtgaaacgatagaagaa
tgttgggatcatgatgcagaagccaggttatcagctggatgtgtaggtgaaagaattact
cagatgcaaagactaacaaatatcattactacagaggacattgtaacagtggtcacaatg
gtgacaaatgttgactttcctcccaaagaatctagtctatga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (24)   
   RefSeq(nuc) (2)   
   GenBank (11)   
   EMBL (11)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (60)   

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