KEGG   Mus musculus (house mouse): 11491
Entry
11491             CDS       T01002                                 
Symbol
Adam17, CD156b, Tace
Name
(RefSeq) a disintegrin and metallopeptidase domain 17
  KO
K06059  disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04148  Efferocytosis
mmu04330  Notch signaling pathway
mmu05010  Alzheimer disease
mmu05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    11491 (Adam17)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    11491 (Adam17)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    11491 (Adam17)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    11491 (Adam17)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    11491 (Adam17)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mmu04090]
    11491 (Adam17)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     11491 (Adam17)
Peptidases and inhibitors [BR:mmu01002]
 Metallo peptidases
  Family M12: astacin/adamalysin family
   11491 (Adam17)
CD molecules [BR:mmu04090]
 Proteins
  11491 (Adam17)
SSDB
Motif
Pfam: Reprolysin_2 Reprolysin_5 ADAM17_MPD Disintegrin Reprolysin_3 Reprolysin Reprolysin_4 Pep_M12B_propep
Other DBs
NCBI-GeneID: 11491
NCBI-ProteinID: NP_033745
MGI: 1096335
Ensembl: ENSMUSG00000052593
UniProt: Q9Z0F8
Position
12:complement(21373510..21423633)
AA seq 827 aa
MRRRLLILTTLVPFVLAPRPPEEAGSGSHPRLEKLDSLLSDYDILSLANIQQHSIRKRDL
QSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQNFFSGHVV
GEPDSRVLAHIGDDDVTVRINTDGAEYNVEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQS
PKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNM
AKSFPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYNPTVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACVDTDNSC
KVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMD
SASVRIIKPFPAPQTPGRLQALQPAAMMPPVPAAPKLDHQRMDTIQEDPSTDSHADDDGF
EKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC
NT seq 2484 nt   +upstreamnt  +downstreamnt
atgaggcggcgtctcctcatcctgaccactttggtgcctttcgtcctggcaccccgacct
ccggaggaagcaggctctggctcccatccgcgacttgagaagcttgattctttgctctca
gactacgacatcctctccttagctaatattcagcagcactccataaggaaaagggatcta
cagtctgcgacacacttagaaacattactaactttttcagctttgaaaagacattttaaa
ttatacttgacatcaagtaccgaacgcttttcacaaaacttgagagtcgtggtggtggac
gggaaagaagaaagcgagtacagcgtgaagtggcagaacttcttcagtggtcacgtggtt
ggtgagcctgactctagggttctagcccacataggagatgatgatgttacagtgagaatc
aacacagatggggcagaatataacgtagagccactttggaggtttgtcaatgatactaaa
gataaacgaatgctggtgtataagtctgaagatatcaaggatttttcacgtttgcagtct
ccaaaagtatgtggttatttaaatgcagatagtgaagagctgcttccaaaagggctcata
gacagagagccatctgaagagtttgttcgtcgagtgaagagacgagctgaacctaacccc
ttgaagaatacttgtaaattactggtggtagcagatcatcgattttataaatacatgggc
cgtggagaagagagcaccactacaaattacttaatagagctaattgaccgagttgatgac
atataccggaacacgtcgtgggataatgcagggtttaaagggtatggagtgcagatagag
cagattcgaattctcaagtctccacaagaggtaaaacctggtgaaagacacttcaatatg
gcaaaaagtttcccaaacgaagagaaggatgcttgggatgtgaagatgctattagagcaa
tttagctttgatatagctgaagaagcatctaaagtctgcctggctcatcttttcacgtac
caggattttgatatgggaactcttggattagcttacgttggttctcccagagcaaacagt
catggaggggtttgtccaaaagcttattacaacccaactgtgaagaaaaacatctattta
aatagtggtctgactagtactaaaaattatggcaaaactattctcacaaaggaagctgac
ctggttacaactcatgaattgggacataattttggagcagaacatgaccctgatgggcta
gcagaatgtgccccaaatgaggaccaaggaggaaagtatgtcatgtatcccatagctgtg
agcggtgaccacgagaataataagatgttttcaaactgcagtaaacagtccatctacaag
accatagaaagtaaggctcaagagtgcttccaggagcgcagcaacaaggtgtgtggcaac
tccagggtggatgaaggagaggagtgtgacccgggtattatgtacctgaacaacgacacc
tgctgcaatagtgactgcacactgaagccgggtgtgcagtgcagtgataggaacagtcct
tgctgtaaaaactgtcagtttgagacggcgcagaagaagtgccaggaggctattaatgct
acatgcaaaggagtgtcttactgcacagggaatagcagtgagtgccccccacccggagat
gctgaagatgacactgtgtgcttggaccttggcaagtgcaaggctgggaaatgcatccct
ttctgcaagagggagcaggagctggagtcctgcgcatgcgttgacactgacaactcgtgc
aaggtgtgctgcaggaacctttctggcccgtgtgtgccgtacgtcgatgcagagcaaaag
aacttgtttttgaggaaagggaagccatgtacagtagggttttgcgacatgaatggcaaa
tgtgagaaacgagtacaggacgtaattgagcgattttgggatttcattgaccagctgagc
atcaacacttttgggaagtttctggcagataacatcgttgggtctgttctggttttctcc
ttgatattttggattcctttcagcattcttgtccactgtgtggataagaaactggacaag
cagtatgaatccctgtctctgtttcatcacagtaacattgagatgctgagcagcatggac
tcagcatctgttcgcatcatcaagccctttcctgcaccccagactccaggtcgtctgcag
gccctgcagccagctgccatgatgccgccagtacctgcagctccaaaactggaccaccag
aggatggacaccatccaggaagaccccagcacagactcacatgcagatgatgacggtttt
gagaaggaccccttccccaacagcagcacagctgccaagtcctttgaggatctcacagac
cacccagtcaccaggagcgaaaaggcggcctcattcaagctgcagcgtcagagccgagtt
gacagcaaagagacagagtgctag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (54)   
   RefSeq(nuc) (6)   
   GenBank (24)   
   EMBL (24)   
Protein domain (8)   
   Pfam (8)   
All databases (103)   

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