KEGG   Mus musculus (house mouse): 11682
Entry
11682             CDS       T01002                                 
Symbol
Alk, CD246, Tcrz
Name
(RefSeq) anaplastic lymphoma kinase
  KO
K05119  anaplastic lymphoma kinase [EC:2.7.10.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05200  Pathways in cancer
mmu05223  Non-small cell lung cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    11682 (Alk)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    11682 (Alk)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    11682 (Alk)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    11682 (Alk)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mmu04090]
    11682 (Alk)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     11682 (Alk)
Protein kinases [BR:mmu01001]
 Receptor tyrosine kinases (RTK)
  ALK family
   11682 (Alk)
CD molecules [BR:mmu04090]
 Proteins
  11682 (Alk)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase MAM Gly_rich Ldl_recept_a FXa_inhibition
Other DBs
NCBI-GeneID: 11682
NCBI-ProteinID: NP_031465
MGI: 103305
Ensembl: ENSMUSG00000055471
UniProt: P97793
Position
17:complement(72174206..72911719)
AA seq 1621 aa
MGAAGFLWLLPPLLLAAASYSGAATDQRAGSPASGPPLQPREPLSYSRLQRKSLAVDFVV
PSLFRVYARDLLLPQPRSPSEPEAGGLEARGSLALDCEPLLRLLGPLPGISWADGASSPS
PEAGPTLSRVLKGGSVRKLRRAKQLVLELGEETILEGCIGPPEEVAAVGILQFNLSELFS
WWILHGEGRLRIRLMPEKKASEVGREGRLSSAIRASQPRLLFQIFGTGHSSMESPSETPS
PPGTFMWNLTWTMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHNHGNQSWSWRHVPSE
EASRMNLLDGPEAEHSQEMPRGSFLLLNTSADSKHTILSPWMRSSSDHCTLAVSVHRHLQ
PSGRYVAQLLPHNEAGREILLVPTPGKHGWTVLQGRVGRPANPFRVALEYISSGNRSLSA
VDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDEGQLCSKLPA
GFYCNFENGFCGWTQSPLSPHMPRWQVRTLRDAHSQGHQGRALLLSTTDILASEGATVTS
ATFPAPMKNSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQSRTVWHVATDEGLSLWQHT
VLSLLDVTDRFWLQIVTWWGPGSRATVGFDNISISLDCYLTISGEEKMSLNSVPKSRNLF
EKNPNKESKSWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGS
EGPLKGVQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKGDTLYILVG
QQGEDACPRANQLIQKVCVGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPV
PLIIAAGGGGRAYGAKTETFHPERLESNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSL
LEGAAGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGV
SFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAD
DGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSP
EYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVS
GMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILL
ELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCL
LTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFG
VLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF
AIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQPAKHEEA
SAAPQPAALTAPGPSVKKPPGAGAGAGAGAGAGPVPRGAADRGHVNMAFSQPNPPPELHK
GPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRRAEAA
LLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAAPGDTMLKSKNKVTQPG
P
NT seq 4866 nt   +upstreamnt  +downstreamnt
atgggagctgctgggttcctgtggctgctgcctccactgcttttggcagcagcctcgtac
tccggagctgcaaccgatcagcgcgcgggttccccagcctcagggcctcctctgcagccc
cgggagccgctcagttattcgcgcctgcagaggaagagtctggcagtggacttcgttgta
ccctcgctcttccgcgtctatgcccgagacctgctgctaccgcagccacggtccccctcg
gagcccgaggctggcgggctggaggcgcggggatcactggccctggattgtgagcctctg
ctcaggctgctggggccactgcctggaatctcctgggcagatggagccagttctcctagt
cccgaggcgggtccgacgctgtccagggtgctgaagggaggctcggtgcgcaagctcagg
cgtgccaaacagctggtgctggagctgggcgaggagacgattcttgaaggctgtattggt
cccccagaggaggtagcggctgtggggatactccagttcaacctcagcgagctgttcagc
tggtggattctccacggcgaagggaggctgaggatccgcctgatgcctgagaagaaggca
tcggaagtgggcagggagggaaggctatccagtgcgatccgagcctcccagccccgcctt
ctcttccagatcttcgggacgggacacagctccatggagtcaccctcagaaacgccttct
cctcctggtaccttcatgtggaatctgacctggacgatgaaagactccttccctttcctt
tcccaccgcagtcgatatggtctggagtgcagctttgacttcccctgtgagctggaatat
tctcctcccctgcacaaccacgggaatcagagctggtcctggcgccatgtgccctccgag
gaggcctcgaggatgaacttgctggatgggccagaggcagagcattctcaagagatgccc
agaggctccttcctcctcctgaacacctctgcagattccaagcataccattctgagccca
tggatgaggagcagtagtgatcactgcacactggctgtctccgtgcacagacatctacag
ccttcggggagatatgttgcccagctcctaccccacaacgaagctggaagagagattctt
ttggtgcccaccccagggaagcatggctggacagtgctgcaggggagagtcgggcgccca
gcaaacccatttcgagtggctctggaatacatctccagtggcaaccggagcttgtcggcg
gtggatttctttgccctgaagaactgcagtgaagggacatccccaggctccaagatggca
ttgcagagttccttcacttgttggaatgggaccgtcctccagctcgggcaagcctgtgat
ttccaccaggactgtgcccaaggagaagatgagggccagctgtgcagtaaacttcctgct
ggattttactgtaactttgaaaatggcttctgtggctggacccaaagtccactctcaccc
catatgccccggtggcaagtgaggaccctaagagatgcccattcccagggccaccaaggc
cgtgccctgttgctcagcaccactgacatcctcgcttctgaaggtgcaacagtgaccagt
gccaccttccctgcaccaatgaaaaattctccttgtgagctccgcatgtcctggctcatc
cgcggggttttgagaggaaacgtatctctggtgctggtggagaacaaaaccggaaaggag
caaagccggactgtctggcatgtcgccactgacgaaggcttaagcctgtggcagcataca
gtgctgtccctcctcgatgtgactgacaggttctggctgcagatagtcacatggtggggt
ccaggatccagggcaaccgtgggatttgacaacatttccatcagcctcgactgctacctt
accatcagtggagaggagaaaatgtccctgaattcagtacccaaatctagaaatctgttt
gagaaaaacccaaacaaggagtcaaaatcctgggcaaacatatcaggaccaactcccatc
ttcgaccctacagttcactggctgttcaccacgtgtggggccagtggacctcatggcccc
acccaggcacagtgcaacaacgcctaccagaattccaacttgagcgtggtggtgggaagt
gaagggcccttgaagggagtccagatttggaaagtgccagctactgacacctacagtatc
tcgggctacggagcagctggcgggaaaggtgggaaaaacaccatgatgcggtcccatggc
gtgtctgtcctgggcatcttcaatctggagaaaggtgacacactctacatccttgtcggt
cagcaaggggaggatgcctgtcccagggcaaaccaactaatccagaaagtctgtgtgggt
gagaacaatgtcatagaagaagagatccgagtgaacagaagcgtgcacgagtgggcagga
ggaggaggaggtgggggtggagccacctacgtgtttaagatgaaagatggcgtgcctgta
cccctgatcattgcagctggtggtggtggcagggcctatggggccaagacagaaacgttc
cacccagagagactggagagtaactcctcggttctagggctgaacggcaattccggagcc
gcaggtggtggaggcggctggaatgataacacttccttgctctgggccggaaagtctttg
ctggagggtgccgccggaggacattcctgcccccaggccatgaagaagtgggggtgggag
acaagagggggtttcggagggggtggaggggggtgctcctcaggtggaggaggcggagga
tatataggtggcaacgcagcatcaaacaatgaccccgaaatggatggggaagatggggtt
tccttcatcagtccattgggtatcctgtacaccccggccttaaaagtgatggagggccac
ggggaagtgaatatcaagcattatctaaactgcagtcactgcgaggtagacgaatgtcac
atggaccccgagagccacaaagtcatctgcttctgtgatcatgggaccgtgctggctgat
gatggtgtctcctgcattgtgtcacccaccccggagccccacctgccgctctcattgatc
ctctccgtcgtgacctctgccctggtggctgcccttgttctggcattctccggcatcatg
attgtgtaccgtcggaagcaccaggagttgcaggctatgcagatggaactgcagagcccc
gagtataagctgagcaagctacggacctcgaccatcatgaccgactacaaccccaactac
tgcttcgctggcaagacttcctccatcagtgacctgaaagaagtgccacggaaaaacatc
acactcatccggggcctaggccatggcgcatttggggaggtgtatgaaggccaggtgtct
ggaatgcccaatgacccaagccctctacaagtggctgtaaagacgctgccagaagtgtgt
tcagaacaagatgagctggactttctcatggaagctctgatcatcagcaaattcaaccac
cagaatattgttcgctgcatcggggtgagtctacaagccctgccccgcttcatcctgctg
gaactcatggctggcggagacctcaagtccttcctcagggagacacgccctcgcccgaac
caacccacctccctggccatgctggaccttctgcatgtggctcgggacattgcctgtggc
tgtcagtacctagaggagaatcactttatccaccgggatattgctgctagaaactgtctg
ttgacctgcccaggagctggaagaatagcaaagattggagactttgggatggcccgagat
atctacagggccagctactaccgaaagggaggctgcgccatgctgccggtcaagtggatg
ccccctgaagccttcatggaagggatatttacctctaaaacagacacatggtcttttgga
gtgttgctatgggaaatattttctcttggatatatgccgtaccccagcaagagcaaccag
gaagttctggagtttgtcaccagcggaggacggatggacccgcctaagaactgccccggg
cctgtataccggataatgacgcagtgctggcagcatcagcctgaagacagacccaacttc
gccatcattttggagaggatcgaatactgcacccaggaccccgatgtgatcaacacagct
ctgcccatcgaatacggtccagtagtagaagaggaggagaaagtgcccatgcgccccaaa
gaccccgaggggatgccacctttgctggtgtctccccagcctgcgaagcacgaggaggcg
tccgcagctccccagcccgcagccctgacggcaccaggcccatcggtgaagaagcccccg
ggtgcgggtgcgggcgcgggcgcgggtgcgggtgccggcccggtgccccgaggtgcggcc
gatcggggccacgtgaacatggctttctctcagcccaaccctcccccggagctgcacaaa
ggcccgggatccagaaacaagccgaccagcctgtggaaccccacctacggctcgtggttc
accgagaagcctgccaaaaagacccatcctccgccaggcgccgagccgcaggcgcgggca
ggagcggccgagggtggctggaccgggccgggcgcggggccccgcagagccgaggcagcg
ctgctgctagagccatcggcgctgagcgccaccatgaaggaggtgccgctgttcaggctg
cgccacttcccctgcggcaatgtcaactatggttaccagcaacagggtctccccttggaa
gccacagccgcgccaggggacaccatgctgaaaagcaagaataaggtcacccagccgggg
ccctga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (34)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (11)   
   RefSeq(nuc) (5)   
   GenBank (3)   
   EMBL (3)   
Protein domain (6)   
   Pfam (6)   
All databases (71)   

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