KEGG   Mus musculus (house mouse): 12567
Entry
12567             CDS       T01002                                 
Symbol
Cdk4, Crk3
Name
(RefSeq) cyclin dependent kinase 4
  KO
K02089  cyclin-dependent kinase 4 [EC:2.7.11.22]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu01522  Endocrine resistance
mmu04110  Cell cycle
mmu04115  p53 signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04218  Cellular senescence
mmu04530  Tight junction
mmu04660  T cell receptor signaling pathway
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04934  Cushing syndrome
mmu05160  Hepatitis C
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05166  Human T-cell leukemia virus 1 infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05169  Epstein-Barr virus infection
mmu05200  Pathways in cancer
mmu05203  Viral carcinogenesis
mmu05212  Pancreatic cancer
mmu05214  Glioma
mmu05218  Melanoma
mmu05219  Bladder cancer
mmu05220  Chronic myeloid leukemia
mmu05222  Small cell lung cancer
mmu05223  Non-small cell lung cancer
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    12567 (Cdk4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    12567 (Cdk4)
   04115 p53 signaling pathway
    12567 (Cdk4)
   04218 Cellular senescence
    12567 (Cdk4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    12567 (Cdk4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    12567 (Cdk4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    12567 (Cdk4)
   05203 Viral carcinogenesis
    12567 (Cdk4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    12567 (Cdk4)
   05225 Hepatocellular carcinoma
    12567 (Cdk4)
   05214 Glioma
    12567 (Cdk4)
   05220 Chronic myeloid leukemia
    12567 (Cdk4)
   05218 Melanoma
    12567 (Cdk4)
   05219 Bladder cancer
    12567 (Cdk4)
   05224 Breast cancer
    12567 (Cdk4)
   05222 Small cell lung cancer
    12567 (Cdk4)
   05223 Non-small cell lung cancer
    12567 (Cdk4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    12567 (Cdk4)
   05160 Hepatitis C
    12567 (Cdk4)
   05164 Influenza A
    12567 (Cdk4)
   05162 Measles
    12567 (Cdk4)
   05163 Human cytomegalovirus infection
    12567 (Cdk4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    12567 (Cdk4)
   05169 Epstein-Barr virus infection
    12567 (Cdk4)
   05165 Human papillomavirus infection
    12567 (Cdk4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    12567 (Cdk4)
   04934 Cushing syndrome
    12567 (Cdk4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    12567 (Cdk4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    12567 (Cdk4)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     12567 (Cdk4)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: CMGC group
  CDK family
   12567 (Cdk4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Haspin_kinase ABC1 Kdo Kinase-like
Other DBs
NCBI-GeneID: 12567
NCBI-ProteinID: NP_034000
MGI: 88357
Ensembl: ENSMUSG00000006728
UniProt: P30285 Q545C3
Position
10:126899404..126903157
AA seq 303 aa
MAATRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAAGGGLPVSTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDL
MRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
EVSLPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKEES
DAE
NT seq 912 nt   +upstreamnt  +downstreamnt
atggctgccactcgatatgaacccgtggctgaaattggtgtcggtgcctatgggacggtg
tacaaagcccgagatccccacagtggccactttgtggccctcaagagtgtgagagttcct
aatggaggagcagctggagggggccttcccgtcagcacagttcgtgaggtggccttgtta
aggaggctggaggcctttgaacatcccaatgttgtacggctgatggatgtctgtgctact
tcccgaactgatcgggacatcaaggtcaccctagtgtttgagcatatagaccaggacctg
aggacatacctggacaaagcacctccaccgggcctgccggttgagaccattaaggatcta
atgcgtcagtttctaagcggcctggattttcttcatgcaaactgcattgttcaccgggac
ctgaagccagagaacattctagtgacaagtaatgggaccgtcaagctggctgactttggc
ctagctagaatctacagctaccagatggccctcacgcctgtggtggttacgctctggtac
cgagctcctgaagttcttctgcagtctacatacgcaacacccgtggacatgtggagcgtt
ggctgtatctttgcagagatgttccgtcggaagcctctcttctgtggaaactctgaagcc
gaccagttggggaaaatctttgatctcattggattgcctccagaagacgactggcctcga
gaggtatctctacctcgaggagcctttgcccccagagggcctcggccagtgcagtcagtg
gtgccagagatggaggagtctggagcgcagctgctactggaaatgctgacctttaaccca
cataagcgaatctctgccttccgagccctgcagcactcctacctgcacaaggaggaaagc
gacgcagagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (28)   
   KEGG PATHWAY (28)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (40)   
   RefSeq(nuc) (2)   
   GenBank (19)   
   EMBL (19)   
Protein domain (7)   
   Pfam (7)   
All databases (97)   

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