KEGG   Mus musculus (house mouse): 13433
Entry
13433             CDS       T01002                                 
Symbol
Dnmt1, Cxxc9, Dnmt, Dnmt1o, MCMT, MTase, Met-1, Met1, MommeD2, m.MmuI
Name
(RefSeq) DNA methyltransferase 1
  KO
K00558  DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00270  Cysteine and methionine metabolism
mmu01100  Metabolic pathways
mmu05206  MicroRNAs in cancer
Module
mmu_M00035  Methionine degradation
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    13433 (Dnmt1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    13433 (Dnmt1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:mmu03000]
    13433 (Dnmt1)
   03032 DNA replication proteins [BR:mmu03032]
    13433 (Dnmt1)
   03036 Chromosome and associated proteins [BR:mmu03036]
    13433 (Dnmt1)
  09183 Protein families: signaling and cellular processes
   02048 Prokaryotic defense system [BR:mmu02048]
    13433 (Dnmt1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     13433 (Dnmt1)
Transcription factors [BR:mmu03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    13433 (Dnmt1)
DNA replication proteins [BR:mmu03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    13433 (Dnmt1)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    13433 (Dnmt1)
Prokaryotic defense system [BR:mmu02048]
 Restriction and modification system (R-M system)
  Type II R-M system
   DNA methyltransferases
    13433 (Dnmt1)
SSDB
Motif
Pfam: BAH DNA_methylase DNMT1-RFD DMAP_binding zf-CXXC HTH_12
Other DBs
NCBI-GeneID: 13433
NCBI-ProteinID: NP_001186360
MGI: 94912
Ensembl: ENSMUSG00000004099
UniProt: P13864 Q3UHZ3
Structure
Position
9:complement(20818501..20871084)
AA seq 1620 aa
MPARTAPARVPALASPAGSLPDHVRRRLKDLERDGLTEKECVREKLNLLHEFLQTEIKSQ
LCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGTHTLTQKANGCPANGSRPTWRAEMA
DSNRSPRSRPKPRGPRRSKSDSDTLSVETSPSSVATRRTTRQTTITAHFTKGPTKRKPKE
ESEEGNSAESAAEERDQDKKRRVVDTESGAAAAVEKLEEVTAGTQLGPEEPCEQEDDNRS
LRRHTRELSLRRKSKEDPDREARPETHLDEDEDGKKDKRSSRPRSQPRDPAAKRRPKEAE
PEQVAPETPEDRDEDEREEKRRKTTRKKLESHTVPVQSRSERKAAQSKSVIPKINSPKCP
ECGQHLDDPNLKYQQHPEDAVDEPQMLTSEKLSIYDSTSTWFDTYEDSPMHRFTSFSVYC
SRGHLCPVDTGLIEKNVELYFSGCAKAIHDENPSMEGGINGKNLGPINQWWLSGFDGGEK
VLIGFSTAFAEYILMEPSKEYEPIFGLMQEKIYISKIVVEFLQNNPDAVYEDLINKIETT
VPPSTINVNRFTEDSLLRHAQFVVSQVESYDEAKDDDETPIFLSPCMRALIHLAGVSLGQ
RRATRRVMGATKEKDKAPTKATTTKLVYQIFDTFFSEQIEKYDKEDKENAMKRRRCGVCE
VCQQPECGKCKACKDMVKFGGTGRSKQACLKRRCPNLAVKEADDDEEADDDVSEMPSPKK
LHQGKKKKQNKDRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLA
RVTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYIHSKVKVIYK
APSENWAMEGGTDPETTLPGAEDGKTYFFQLWYNQEYARFESPPKTQPTEDNKHKFCLSC
IRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSVYLPPEAFTFNIKVASPV
KRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIHCGKKKGKVNEADIKLR
LYKFYRPENTHRSYNGSYHTDINMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQ
GGPDRFYFLEAYNSKTKNFEDPPNHARSPGNKGKGKGKGKGKGKHQVSEPKEPEAAIKLP
KLRTLDVFSGCGGLSEGFHQAGISETLWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKL
VMAGEVTNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDY
YRPRFFLLENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILA
AAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEI
QNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSPLVAARMRHIPLFPGSDWR
DLPNIQVRLGDGVIAHKLQYTFHDVKNGYSSTGALRGVCSCAEGKACDPESRQFSTLIPW
CLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQG
FPDSYRFFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLSSARESASAAVKAKEEAATKD
NT seq 4863 nt   +upstreamnt  +downstreamnt
atgccagcgcgaacagctccagcccgagtgcctgcgcttgcctccccggcaggctcgctc
ccggaccatgtccgcaggcggctcaaagacttggaaagagatggcttaacagaaaaggag
tgtgtgagggagaaattaaacttactgcatgaattcctgcaaacagaaataaaaagccag
ttgtgtgacttggaaaccaaattacataaagaggaattatctgaggaaggctacctggct
aaagtcaagtccctcttaaataaggatttgtccttggagaacggaacacacactctcact
caaaaagccaacggttgtcccgccaacgggagccggccaacctggagagcagaaatggca
gactcaaatagatccccaagatccaggcccaagcctcggggacccaggagaagcaagtcg
gacagtgacaccctttcagttgaaacttcacctagttccgtggctacgaggagaaccacc
aggcagaccaccatcacggctcacttcacgaagggccccactaaacggaaacccaaggaa
gagtcggaagaggggaactcggctgagtcggctgcagaggagagagaccaggataagaaa
cgcagagttgtagacacagagagtggtgctgcagctgctgtggagaaactggaagaggta
acagcgggaacccagctgggtccggaagagccatgtgaacaggaagatgacaacaggagt
cttcgacgtcacaccagagagctatcattgaggcggaaatcaaaggaggatccagacaga
gaagcaagaccggaaactcacttggacgaggacgaggacggaaaaaaggataaaagaagt
tccagacccaggagccagcccagagatccagctgccaaacggagacccaaggaagcagag
ccagagcaggtagctccagagactcccgaggacagagacgaggatgagagggaggagaag
agacgaaaaacgacacgtaaaaaactggagtcacacaccgttcccgttcagagcagatcg
gagagaaaagccgctcaaagcaaaagtgtgatcccgaagatcaactcaccaaagtgcccc
gagtgtggccagcacctagacgaccctaacctgaagtaccagcagcaccctgaggatgct
gtggatgaaccccagatgttgaccagtgagaaactgtccatctacgactccacctcgacc
tggtttgatacttatgaagattctcccatgcataggttcacttccttcagtgtgtactgc
agtcgcgggcacctgtgtcctgtcgacaccggtctcattgagaagaatgtagagctctac
ttttctgggtgtgccaaagcaattcatgacgagaatccatctatggaaggtggtattaat
ggcaaaaacctcgggccaatcaatcagtggtggctcagtggctttgatggtggcgagaag
gtgctcattggcttctccactgcatttgctgaatacattttgatggagcccagcaaagag
tatgagccaatatttgggctgatgcaggagaaaatttacatcagcaagattgttgttgag
ttcctgcaaaacaatcctgatgctgtatatgaagacctgatcaataagattgagaccact
gttcctccttctaccattaatgtgaaccggttcacagaggactccctcttacgccacgcc
cagtttgtagtgagccaggtagagagttacgacgaagccaaggacgatgatgagaccccc
atcttcttgtctccctgtatgagagccctgatccatttggctggtgtctccctgggacag
aggcgagcaacaaggcgcgtcatgggtgctaccaaggagaaggacaaagcacccacgaaa
gccaccaccaccaagctggtctatcagatctttgacactttcttctcagagcagattgag
aagtatgataaggaggacaaggagaatgccatgaagcgccgccgctgtggtgtctgtgag
gtctgtcagcagcctgagtgtgggaagtgcaaggcgtgcaaagatatggtgaagtttggt
ggcactggacggagtaagcaggcttgcctcaagaggaggtgtcctaacttggcggtgaag
gaggcagacgacgatgaagaggctgatgatgatgtgtcagagatgccatcacccaaaaag
ctgcatcaggggaagaagaagaagcagaacaaggaccgcatctcctggcttgggcagcct
atgaagattgaagagaatagaacttactatcagaaggtgagcatcgatgaggagatgcta
gaggtgggcgactgcgtctcggtcattccagatgattcctccaaaccactctatctagcc
agggtcacagctctgtgggaagacaaaaatggtcagatgatgttccatgcgcactggttc
tgcgctgggacagacacagtcctgggagccacctccgaccccctggaactgttcctggtg
ggcgagtgcgaaaacatgcagctttcctacatccacagcaaggtcaaggtcatctacaaa
gccccttctgaaaactgggccatggagggaggcacagaccctgagaccacactgcctggg
gctgaggatggcaagacttacttcttccagctctggtacaaccaggagtacgcaaggttt
gaatccccacccaagacccagccgaccgaggacaacaagcacaagttctgcctatcttgt
atccggctggctgagctgagacaaaaagaaatgcccaaggtcctggaacaaattgaggag
gtggatggccgggtctactgcagttccatcaccaagaatggtgttgtctaccgactgggt
gacagtgtgtaccttcctcccgaggcctttactttcaacatcaaagtggctagccccgtg
aaacgcccaaagaaggatcctgtgaacgagaccctgtaccctgagcactaccgcaagtat
tctgactacatcaaggggagcaacctggatgctccagagccctatcgcatcggtcggata
aaagagatccactgtggcaagaagaaaggcaaggtcaacgaggcagacatcaagctgagg
ctctacaagttctacaggcctgagaatacccacaggtcctacaacggatcctatcacact
gacatcaacatgctttactggagcgacgaggaagctgtggtgaacttcagcgacgtgcag
ggccgctgtaccgtggagtacggggaagacctacttgagagcatccaggattattcacaa
gggggccctgaccgcttctacttcctcgaggcctacaattcaaagaccaagaactttgaa
gacccaccaaaccatgcccgcagccctgggaacaaagggaaagggaaggggaaagggaag
gggaaggggaagcatcaggtgtcagagcccaaagagcctgaggcagccatcaaactgccc
aagctccggaccctggatgtgttttccggctgtggagggttatcggaaggattccaccaa
gcaggcatctcggaaacgctgtgggccatcgagatgtgggacccggcagcccaggcattt
cggctgaacaaccccggcaccacagtgttcacagaggactgcaacgtgcttcttaagctg
gtcatggctggggaggtgaccaactctctgggccaaaggctgccacagaagggcgatgtg
gagatgctgtgtggtgggccaccctgccagggcttcagtggcatgaaccgcttcaactcc
cgcacttactccaagttcaaaaactccctagtggtctccttcctcagctactgtgactac
taccggcctcggttcttccttctggagaacgtcaggaacttcgtgtcctacagacgctcc
atggtgctgaagctcacactgcgctgcctggtccgcatgggctaccagtgcacctttggt
gtgctccaggctggacagtatggcgtggcccagacacgaaggagggccatcatcttggct
gcagccccaggagaaaagctgcctctgttcccagagcctctgcatgtgtttgcgccccgt
gcctgccagctgagcgttgtggtggatgacaagaagtttgttagcaacataacgaggctg
agctcggggcccttccgaaccatcaccgtgcgagacaccatgtctgacctccccgagatc
cagaatggagcctcgaattctgagatcccctacaatggagagccactgtcctggttccag
aggcagctgcgaggatcacactaccagcccatcctcagggaccatatctgcaaggacatg
agcccactggtggctgcccgcatgcggcacatcccactgttcccaggatcagattggcgt
gacctgcccaacatacaggtgcggctgggagatggcgtcatagcccataagctacagtac
acctttcatgatgtgaaaaatggctacagcagcaccggtgccctgcgtggagtctgttcc
tgtgcagaaggcaaggcctgcgaccctgagtccaggcaattcagcaccctcatcccctgg
tgcctgccgcacactgggaaccggcacaaccactgggctggcctctacgggcgtctggag
tgggatggcttcttcagcaccactgtcaccaaccctgagcccatgggcaagcagggtcgg
gtgctccacccggagcagcaccgggtcgtgagtgttcgggaatgtgcccgctcccagggc
tttccagatagctaccggttcttcggcaacatcctggacagacaccggcaggtgggtaat
gctgtgccaccacccctggccaaagccattggcctggagattaagctctgcctgctgtcc
agtgctcgggagagcgcatcagctgcagttaaagcaaaagaggaggctgctaccaaggac
tag

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (68)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (58)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (45)   
   RefSeq(nuc) (7)   
   GenBank (19)   
   EMBL (19)   
3D Structure (11)   
   PDB (11)   
Protein domain (6)   
   Pfam (6)   
All databases (157)   

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