KEGG   Mus musculus (house mouse): 13435
Entry
13435             CDS       T01002                                 
Symbol
Dnmt3a, MmuIIIA
Name
(RefSeq) DNA methyltransferase 3A
  KO
K17398  DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00270  Cysteine and methionine metabolism
mmu01100  Metabolic pathways
mmu04148  Efferocytosis
mmu05206  MicroRNAs in cancer
Module
mmu_M00035  Methionine degradation
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    13435 (Dnmt3a)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    13435 (Dnmt3a)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    13435 (Dnmt3a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:mmu03000]
    13435 (Dnmt3a)
   03032 DNA replication proteins [BR:mmu03032]
    13435 (Dnmt3a)
   03036 Chromosome and associated proteins [BR:mmu03036]
    13435 (Dnmt3a)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     13435 (Dnmt3a)
Transcription factors [BR:mmu03000]
 Eukaryotic type
  Zinc finger
   Cys4 GATA-factors
    13435 (Dnmt3a)
DNA replication proteins [BR:mmu03032]
 Eukaryotic type
  DNA Replication Termination Factors
   DNA methylation enzymes
    13435 (Dnmt3a)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    13435 (Dnmt3a)
SSDB
Motif
Pfam: ADD_DNMT3 ADDz_Dnmt3b DNA_methylase PWWP
Other DBs
NCBI-GeneID: 13435
NCBI-ProteinID: NP_001258682
MGI: 1261827
Ensembl: ENSMUSG00000020661
UniProt: O88508
Structure
Position
12:3851559..3964442
AA seq 908 aa
MPSSGPGDTSSSSLEREDDRKEGEEQEENRGKEERQEPSATARKVGRPGRKRKHPPVESS
DTPKDPAVTTKSQPMAQDSGPSDLLPNGDLEKRSEPQPEEGSPAAGQKGGAPAEGEGTET
PPEASRAVENGCCVTKEGRGASAGEGKEQKQTNIESMKMEGSRGRLRGGLGWESSLRQRP
MPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAVMNAVEENQASGESQKVEEASP
PAVQQPTDPASPTVATTPEPVGGDAGDKNATKAADDEPEYEDGRGFGIGELVWGKLRGFS
WWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPM
YRKAIYEVLQVASSRAGKLFPACHDSDESDSGKAVEVQNKQMIEWALGGFQPSGPKGLEP
PEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTTEKPKVKEIIDERTRERLVYEVR
QKCRNIEDICISCGSLNVTLEHPLFIGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGR
EVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSR
LQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASE
VCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLY
EGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKE
VSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGK
DQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAP
LKEYFACV
NT seq 2727 nt   +upstreamnt  +downstreamnt
atgccctccagcggccccggggacaccagcagctcctctctggagcgggaggatgatcga
aaggaaggagaggaacaggaggagaaccgtggcaaggaagagcgccaggagcccagcgcc
acggcccggaaggtggggaggcctggccggaagcgcaagcacccaccggtggaaagcagt
gacacccccaaggacccagcagtgaccaccaagtctcagcccatggcccaggactctggc
ccctcagatctgctacccaatggagacttggagaagcggagtgaaccccaacctgaggag
gggagcccagctgcagggcagaagggtggggccccagctgaaggagagggaactgagacc
ccaccagaagcctccagagctgtggagaatggctgctgtgtgaccaaggaaggccgtgga
gcctctgcaggagagggcaaagaacagaagcagaccaacatcgaatccatgaaaatggag
ggctcccggggccgactgcgaggtggcttgggctgggagtccagcctccgtcagcgaccc
atgccaagactcaccttccaggcaggggacccctactacatcagcaaacggaaacgggat
gagtggctggcacgttggaaaagggaggctgagaagaaagccaaggtaattgcagtaatg
aatgctgtggaagagaaccaggcctctggagagtctcagaaggtggaggaggccagccct
cctgctgtgcagcagcccacggaccctgcttctccgactgtggccaccacccctgagcca
gtaggaggggatgctggggacaagaatgctaccaaagcagccgacgatgagcctgagtat
gaggatggccggggctttggcattggagagctggtgtgggggaaacttcggggcttctcc
tggtggccaggccgaattgtgtcttggtggatgacaggccggagccgagcagctgaaggc
actcgctgggtcatgtggttcggagatggcaagttctcagtggtgtgtgtggagaagctc
atgccgctgagctccttctgcagtgcattccaccaggccacctacaacaagcagcccatg
taccgcaaagccatctacgaagtcctccaggtggccagcagccgtgccgggaagctgttt
ccagcttgccatgacagtgatgaaagtgacagtggcaaggctgtggaagtgcagaacaag
cagatgattgaatgggccctcggtggcttccagccctcgggtcctaagggcctggagcca
ccagaagaagagaagaatccttacaaggaagtttacaccgacatgtgggtggagcctgaa
gcagctgcttacgccccacccccaccagccaagaaacccagaaagagcacaacagagaaa
cctaaggtcaaggagatcattgatgagcgcacaagggagcggctggtgtatgaggtgcgc
cagaagtgcagaaacatcgaggacatttgtatctcatgtgggagcctcaatgtcaccctg
gagcacccactcttcattggaggcatgtgccagaactgtaagaactgcttcttggagtgt
gcttaccagtatgacgacgatgggtaccagtcctattgcaccatctgctgtggggggcgt
gaagtgctcatgtgtgggaacaacaactgctgcaggtgcttttgtgtcgagtgtgtggat
ctcttggtggggccaggagctgctcaggcagccattaaggaagacccctggaactgctac
atgtgcgggcataagggcacctatgggctgctgcgaagacgggaagactggccttctcga
ctccagatgttctttgccaataaccatgaccaggaatttgaccccccaaaggtttaccca
cctgtgccagctgagaagaggaagcccatccgcgtgctgtctctctttgatgggattgct
acagggctcctggtgctgaaggacctgggcatccaagtggaccgctacattgcctccgag
gtgtgtgaggactccatcacggtgggcatggtgcggcaccagggaaagatcatgtacgtc
ggggacgtccgcagcgtcacacagaagcatatccaggagtggggcccattcgacctggtg
attggaggcagtccctgcaatgacctctccattgtcaaccctgcccgcaagggactttat
gagggtactggccgcctcttctttgagttctaccgcctcctgcatgatgcgcggcccaag
gagggagatgatcgccccttcttctggctctttgagaatgtggtggccatgggcgttagt
gacaagagggacatctcgcgatttcttgagtctaaccccgtgatgattgacgccaaagaa
gtgtctgctgcacacagggcccgttacttctggggtaaccttcctggcatgaacaggcct
ttggcatccactgtgaatgataagctggagctgcaagagtgtctggagcacggcagaata
gccaagttcagcaaagtgaggaccattaccaccaggtcaaactctataaagcagggcaaa
gaccagcatttccccgtcttcatgaacgagaaggaggacatcctgtggtgcactgaaatg
gaaagggtgtttggcttccccgtccactacacagacgtctccaacatgagccgcttggcg
aggcagagactgctgggccgatcgtggagcgtgccggtcatccgccacctcttcgctccg
ctgaaggaatattttgcttgtgtgtaa

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (56)   
   RefSeq(nuc) (8)   
   GenBank (24)   
   EMBL (24)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   Pfam (4)   
All databases (109)   

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