KEGG   Mus musculus (house mouse): 14056
Entry
14056             CDS       T01002                                 
Symbol
Ezh2, Enx-1, Enx1h, KMT6, mKIAA4065
Name
(RefSeq) enhancer of zeste 2 polycomb repressive complex 2 subunit
  KO
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2 [EC:2.1.1.356]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00310  Lysine degradation
mmu01100  Metabolic pathways
mmu03083  Polycomb repressive complex
mmu05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    14056 (Ezh2)
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    14056 (Ezh2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    14056 (Ezh2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mmu03036]
    14056 (Ezh2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     14056 (Ezh2)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     14056 (Ezh2)
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     14056 (Ezh2)
    PRC2.2
     14056 (Ezh2)
SSDB
Motif
Pfam: Ezh2_MCSS PRC2_HTH_1 SET EZH2_WD-Binding preSET_CXC
Other DBs
NCBI-GeneID: 14056
NCBI-ProteinID: NP_031997
MGI: 107940
Ensembl: ENSMUSG00000029687
UniProt: Q61188 Q6AXH7 Q571L5 Q3TZH6
Structure
Position
6:complement(47507208..47613843)
AA seq 746 aa
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEW
KQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPV
PTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
NT seq 2241 nt   +upstreamnt  +downstreamnt
atgggccagactgggaagaaatctgagaagggaccggtttgttggcggaagcgtgtaaaa
tcagagtacatgagactgagacagctcaagaggttcagaagagctgatgaagtaaagact
atgtttagttccaatcgtcagaaaattttggaaagaactgaaaccttaaaccaagagtgg
aagcagcggaggatacagcctgtgcacatcatgacttctgtgagctcattgcgcgggact
agggagtgttcagtcaccagtgacttggattttccagcacaagtcatcccgttaaagacc
ctgaatgcagtcgcctcggtgcctataatgtactcttggtcgcccttacaacagaatttt
atggtggaagacgaaactgttttacataacattccttatatgggggatgaagttctggat
caggatggcactttcattgaagaactaataaaaaattatgatggaaaagtgcatggtgac
agagaatgtggatttataaatgatgaaatttttgtggagttggtaaatgctcttggtcaa
tataatgatgatgatgatgacgatgatggagatgatccagatgaaagagaagaaaaacag
aaagatctagaggataatcgagatgataaagaaacttgcccacctcggaaatttcctgct
gataaaatatttgaagccatttcctcaatgtttccagataagggcaccgcagaagaactg
aaagaaaaatataaagaactcacggagcagcagctcccaggtgctctgcctcctgaatgt
actccaaacatcgatggaccaaatgccaaatctgttcagagggagcaaagcttgcattca
tttcatacgctcttctgtcgacgatgttttaagtatgactgcttcctacatcccttccat
gcaacacccaacacatataagaggaagaacacagaaacagctttggacaacaagccttgt
ggaccacagtgttaccagcatctggagggagctaaggagtttgctgctgctcttactgct
gagcgtataaagacaccacctaaacgcccagggggccgcagaagaggaagacttccgaat
aacagtagcagacccagcacccccaccatcagtgtgctggagtcaaaggatacagacagt
gacagagaagcagggactgaaactgggggagagaacaatgataaagaagaagaagagaaa
aaagatgagacgtccagctcctctgaagcaaattctcggtgtcaaacaccaataaagatg
aagccaaatattgaacctcctgagaatgtggagtggagtggtgctgaagcctccatgttt
agagtcctcattggtacttactacgataacttttgtgccattgctaggctaattgggacc
aaaacatgtagacaggtgtatgagtttagagtcaaggagtccagtatcatagcacctgtt
cccactgaggatgtagacactcctccaagaaagaagaaaaggaaacatcggttgtgggct
gcacactgcagaaagatacaactgaaaaaggacggctcctctaaccatgtttacaactat
caaccctgtgaccatccacggcagccttgtgacagttcgtgcccttgtgtgatagcacaa
aatttttgtgaaaagttttgtcaatgtagttcagagtgtcaaaaccgctttcctggatgt
cggtgcaaagcacaatgcaacaccaaacagtgtccatgctacctggctgtccgagagtgt
gaccctgacctctgtctcacgtgtggagctgctgaccattgggacagtaaaaatgtatcc
tgtaagaactgtagcattcagcggggctctaaaaagcacttactgctggcaccgtctgat
gtggcaggctggggcatctttatcaaagatcctgtacagaaaaatgaattcatctcagaa
tactgtggggagattatttctcaggatgaagcagacagaagaggaaaagtgtatgacaaa
tacatgtgcagctttctgttcaacttgaacaatgattttgtggtggatgcaacccgaaag
ggcaacaaaattcgttttgctaatcattcagtaaatccaaactgctatgcaaaagttatg
atggttaatggtgaccacaggataggcatctttgctaagagggctatccagactggtgaa
gagttgttttttgattacagatacagccaggctgatgccctgaagtatgtgggcatcgaa
cgagaaatggaaatcccttga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (42)   
   UniProt (4)   
   SWISS-PROT (1)   
   RefSeq(pep) (37)   
DNA sequence (63)   
   RefSeq(nuc) (43)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (147)   

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