KEGG   Mus musculus (house mouse): 14287
Entry
14287             CDS       T01002                                 
Symbol
Fpgs
Name
(RefSeq) folylpolyglutamyl synthetase
  KO
K01930  folylpolyglutamate synthase [EC:6.3.2.17]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00790  Folate biosynthesis
mmu01100  Metabolic pathways
mmu01240  Biosynthesis of cofactors
mmu01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    14287 (Fpgs)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    14287 (Fpgs)
Enzymes [BR:mmu01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.17  tetrahydrofolate synthase
     14287 (Fpgs)
SSDB
Motif
Pfam: Mur_ligase_M Mur_ligase_C
Other DBs
NCBI-GeneID: 14287
NCBI-ProteinID: NP_034366
MGI: 95576
Ensembl: ENSMUSG00000009566
UniProt: P48760
Position
2:complement(32572621..32594163)
AA seq 587 aa
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNAS
YLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRN
YGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGA
HQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVW
PGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRD
SAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEK
QASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSL
PRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ
NT seq 1764 nt   +upstreamnt  +downstreamnt
atgtcgtgggcgcggagccgactgtgctcgactctgtccctggcagctgtttctgcgcgt
ggtgcaacgacggagggcgcggcgcggcgggggatgagcgcgtggccagcgccacaggag
ccgggcatggagtatcaggatgctgtgcgcacgctcaacaccctgcaaaccaatgccagc
tacctggagcaggtaaagcgccaacggagtgacccccaggcgcagctggaggctatggag
atgtacctggcacggagtggactgcaggtggaggacttgaaccggctaaacattattcat
gtcactgggaccaaagggaagggctccacctgtgccttcaccgaacggatcctgcggaat
tacggcctgaagaccggcttctttagctctcctcacatggtgcaggtgcgggagcggatt
cgaatcaacgggaaaccaatcagccccgagctcttcaccaagcacttctggtgcctctat
aaccagctggaggagttcaaggacgacagccatgtctccatgccctcttacttccgcttc
ctcacactcatggccttccatgtcttcctccaagagaaggtggacctggcagtggtggag
gtgggcattggcggggcttttgactgcaccaacatcatcagaaagccagtggtgtgtgga
gtctcctctcttggcattgaccacaccagtctactaggagatacagtggagaaaatagca
tggcagaaagggggcatctttaagcctggtgtccctgccttcactgtggtgcagccagaa
ggtcccctggctgtgctgagggatcgagcccagcagattggatgcccgttgtacctgtgt
ccgccattggaagccctggaggaggttggactgccattgagcctgggtctggagggagca
caccagcggtctaatgctgccttggccttgcagctggcccactgttggctggagcggcag
gaccaccaagacatccaggagctgaaggtatccaggccaagcatacggtggcagctgccc
ctggcacctgtgttccgccctacccctcacatgaggcgtgggcttcgggacacagtgtgg
cctggccggacacagatactccagcggggaccccttacctggtacctggatggcgcccat
accaccagcagtgtgcaggcctgtgtgcactggtaccgccagtcattggagcgcagcaaa
cgcaccgatggagggtccgaagtacacatcttgctcttcaactctactggtgacagggac
tctgctgccctgctgaagctgctgcagccctgccagtttgactacgctgtcttctgcccc
aacgtgacagaggtttcatccataggaaatgcagaccagcagaacttcactgtgactctg
gaccaggtgctgctccgctgcctccaacaccagcagcattggaacggcctggctgagaaa
caggccagctccaacctctggagcagctgcggcccagaccctgctgggccaggctccctg
ctgctggccccgcacccacctcagcctactaggacgagctccctcgttttcagctgcatc
tcccacgccttgctgtggatcagccaaggccgggatcccatctttcagccccagagcctt
ccaaggaatcttctcaaccaccccacagccaacagcggggccagcattctccgtgaggct
gctgccatccatgtactggttacaggaagcctgcacctggtgggcggggttctgaaactg
ctggatccctctatgtcccagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (32)   
   RefSeq(nuc) (6)   
   GenBank (13)   
   EMBL (13)   
Protein domain (2)   
   Pfam (2)   
All databases (87)   

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