KEGG   Mus musculus (house mouse): 14450
Entry
14450             CDS       T01002                                 
Symbol
Gart, Gaps, Prgs
Name
(RefSeq) phosphoribosylglycinamide formyltransferase
  KO
K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00230  Purine metabolism
mmu00670  One carbon pool by folate
mmu01100  Metabolic pathways
mmu01523  Antifolate resistance
Module
mmu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    14450 (Gart)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    14450 (Gart)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    14450 (Gart)
Enzymes [BR:mmu01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.2  phosphoribosylglycinamide formyltransferase 1
     14450 (Gart)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.1  phosphoribosylformylglycinamidine cyclo-ligase
     14450 (Gart)
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.13  phosphoribosylamine---glycine ligase
     14450 (Gart)
SSDB
Motif
Pfam: GARS_A Formyl_trans_N AIRS_C GARS_N GARS_C AIRS ATP-grasp CPSase_L_D2 ATP-grasp_3 ATP-grasp_4 ATP-grasp_2 Dala_Dala_lig_C RimK
Other DBs
NCBI-GeneID: 14450
NCBI-ProteinID: NP_034386
MGI: 95654
Ensembl: ENSMUSG00000022962
UniProt: Q64737
Position
16:complement(91418283..91444505)
AA seq 1010 aa
MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQ
FCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIP
TAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSF
GAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAP
QVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEA
QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKD
IGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLP
QLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTR
IYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEG
ELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN
LIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLV
ISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
NT seq 3033 nt   +upstreamnt  +downstreamnt
atggcagcccgagttcttgtcatcggtagcgggggaagggaacataccctggcctggaag
ctcgcacagtctcctcaggtcaagcaagtgttggttgccccaggaaacgcaggcactgcg
tgcgctgggaagatctccaatgctgctgtctctgtcaatgatcacagtgccctcgctcag
ttctgcaaggatgaaaagattgaactcgtagttgtcggaccagaggcccctctggctgca
ggaattgttggggacctgacctctgcaggagtacgatgctttggccccacagcacaagca
gctcaattagagtccagtaagaagtttgctaaagagtttatggaccgccatgaaatccca
actgcacagtggagagcattcaccaaccctgaagatgcctgcagctttattacaagcgcg
aactttcctgctttggttgtgaaggccagtggccttgcagcagggaagggagtgattgtg
gccaagagccaagcggaggcctgcagagctgtacaggagatcatgcaagaaaagtctttc
ggagcagctggtgaaacagttgttgtggaagagtttctggaaggggaagaagtgtcttgc
ctttgcttcactgacgggaagacggtggccgaaatgcccccagcacaagaccataagcga
ttgctggatggagacgaaggccccaacaccggggggatgggagcctactgcccagcacct
caggtttctaaggacttgttagtaaaaattaagaacactattcttcagagagcagtagac
ggcatgcagcaggagggtgcgccgtacacaggaattctttatgctggtataatgctgacc
aaagatggcccaaaagtgttggagtttaattgccgctttggtgatccggaatgccaggtc
atcctcccacttcttaaaagtgacctctatgaggtgatgcagtccaccttggatggcctg
ctgagcgcgtctctgcctgtttggctagaaaaccacagtgccgtaaccgtcgtcatggcg
agtaaagggtaccctggagcctacaccaaaggcgtggagattacagggtttcctgaggcc
caggctttaggactgcaggtattccatgcaggcactgctcttaaagatggcaaagtagtg
accagcgggggcagggtcctcaccgtgacagctgtccaggaaaatctcatgtcagccctt
gctgaggccaggaaaggactcgctgctctaaagtttgagggagccatctatagaaaggac
attggcttccgtgctgtggccttcctccagcggcccaggggcttgacttacaaggactcc
ggagtagacatcgcagctggaaatatgctggttaagaaaattcagcctttagcaaaagcc
acctccagaccaggctgcagtgttgaccttgggggctttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctctggaacagatggtgtgggaactaaacta
aagattgcgcagctgtgcaataagcatgattccatcgggcaggatctggtggccatgtgt
gtgaacgacatcctcgcccagggagcagagcccctcttcttccttgactacttttcctgt
gggaagctcgacctcagtacaactgaagccgtcattgctggaattgctgcagcttgccag
caggctggctgtgccctgctgggtggggagacagcagagatgcccaacatgtaccctcct
ggagagtatgatcttgctgggtttgctgttggtgctatggagagacaccagaagctccct
cagctagaaaggatcaccgaaggggatgctgttattggagtggcttcatctggtcttcac
agcaatgggtttagccttgtgaggaaaatcgtggagaggtcttcgctccaatactcctcc
ccagcacctggtggttgtggagatcagaccttaggggacttacttctaactccaaccagg
atctacagccattcactgctgcccatcatacgttcaggacgtgtcaaagcttttgctcat
atcactggaggcgggttgctggaaaacatccccagagtcctccctcagaagtttggagta
gatttagatgccagcacctggagggtccccaaggtcttctcgtggctacagcaggaagga
gagctctctgaagaagaaatggccaggacattcaactgtgggattggagctgccctggtg
gtgtcaaaggaccaggccgagcaggttctgcatgacgttcggcggcggcaggaggaagcc
tgggtgataggcagtgtcgttgcgtgtcctgaagattcccctcgtgtcagagttaagaat
ctgattgaaaccatacaaacgaatgggtcattggtggcaaatggcttcctgaaaagtaat
ttccctgtgcaacaaaagaaggcaagagtggctgtcttgatatctggaacagggtcgaac
ctccaggcgctcatagatagcacccgggatcccaagagctcctcacatattgttcttgtc
atctccaacaaagccgccgtagccggcttagaccgagctgagcgagctggtattcccacc
agggtaattaatcacaaattatataaaaatcgtgttgagtttgacaatgcagttgaccac
gtcctggaagagttctctgtagacatcgtctgtcttgcagggttcatgaggatcctctct
gggcccttcgtcagaaaatgggacgggaaaatgctcaacatccacccatccttgctccct
tcctttaagggttcaaatgcccacgagcaagtcctggaagctggagtcacaatcactggg
tgtaccgtacactttgtcgctgaagatgtagatgccggacaaatcatcctgcaggaagct
gtccctgtgcggaggggtgacactgtggcaacgctgtctgaacgggtcaaagtggcagaa
cataagatctttcctgccgctcttcagctggtggccagcggggctgtgcagctgcgagaa
gatggcaagatccactgggccaaggagcagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (7)   
   KEGG ENZYME (3)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (75)   
   RefSeq(nuc) (5)   
   GenBank (35)   
   EMBL (35)   
Protein domain (13)   
   Pfam (13)   
All databases (145)   

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