KEGG   Mus musculus (house mouse): 14629
Entry
14629             CDS       T01002                                 
Symbol
Gclc, D9Wsu168e, GLCL-H, Ggcs-hs, Glclc
Name
(RefSeq) glutamate-cysteine ligase, catalytic subunit
  KO
K11204  glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00270  Cysteine and methionine metabolism
mmu00480  Glutathione metabolism
mmu01100  Metabolic pathways
mmu01240  Biosynthesis of cofactors
mmu04216  Ferroptosis
Module
mmu_M00118  Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    14629 (Gclc)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    14629 (Gclc)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    14629 (Gclc)
Enzymes [BR:mmu01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.2  glutamate---cysteine ligase
     14629 (Gclc)
SSDB
Motif
Pfam: GCS GCS2
Other DBs
NCBI-GeneID: 14629
NCBI-ProteinID: NP_034425
MGI: 104990
Ensembl: ENSMUSG00000032350
UniProt: P97494 Q3TEF1 Q3UNA7
Position
9:77661817..77701771
AA seq 637 aa
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAI
NKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDAEASKASQPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLE
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCSKAQSSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYS
LIWKCNQIADELCECPELLGSGFRKAKYSGGKSDPSA
NT seq 1914 nt   +upstreamnt  +downstreamnt
atggggctgctgtcccaaggctcgccactgagctgggaagagacccagcgccacgccgac
cacgtgcggaggcacggcatcctccagttcctgcacatctaccacgcagtcaaggaccgg
cacaaggacgtgctcaagtggggtgacgaggtggagtacatgttggtgtccttcgatcat
gaaaataggaaagtccagttgttactgaatggaggcgatgttcttgagactctgcaggag
aagggggagaggacaaaccccaaccatccgaccctctggagaccagagtatgggagttac
atgatcgaaggaacgcctggccagccctacggaggaacgatgtctgagttcaacactgtg
gaggccaatatgaggaaacgccggaaggaggctacttctgtactaggagagcatcaggct
ctctgcaccatcacttcattccccagactaggctgtcctggattcacactgccagaacac
agacccaacccagaggaaggaggcgcatcaaagtccctcttctttccagatgaagccata
aacaagcacccccgcttcggtactctaacaagaaacatccggcatcggagaggagaaaag
gttgtcatcaatgtgccaatattcaaggacaagaatacaccatctccatttgtagaaaca
tttccagaagatgcggaggcatcaaaggcttctcagccagaccatatctacatggatgcc
atgggattcgggatgggcaactgctgtctccaggtgacattccaagcctgcagcatatct
gaggcaagatacctttatgatcagctggccactatctgcccaattgttatggctttgagt
gctgcatctccattttaccgaggctacgtgtcagacattgattgtcgctggggagtgatt
tctgcctctgtagatgatagaacacgggaggagagaggcctggagcctctgaagaacaat
cgctttaggatcagtaagtctcggtatgactcaatagatagctacctgtctaagtgtggg
gagaagtacaatgacatcgacctgaccatcgataaggagatctacgagcagctcctggag
gaaggcatcgatcatcttctggcacagcacgttgctcatctctttattagagacccactc
accctttttgaagagaaaatacacctggatgatgccaacgagtctgaccattttgagaat
attcagtctacaaactggcagacaatgaggtttaagcctcctcctccaaactcagatatt
ggatggagagtagagttccgaccaatggaggtgcagttaacagactttgagaactctgcc
tatgtggtattcgtggtactgctcactagggtgatcctctcatacaaactagacttcctc
attccgctgtccaaggttgacgagaacatgaaagtggcccagaagcgagatgctgtcttg
caggggatgttttatttcaggaaagacatctgcaaaggcggcaacgctgtggtggacggg
tgcagcaaggcccagagcagctctgagccagctgcagaggagtacaccctgatgagcata
gacaccatcatcaatgggaaggaaggggtatttcctggactcatccccattctgaactcc
tatctggagaacatggaagttgatgtggacacccgatgcagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgactgttgccaggtggatgagagagttc
attgcaaaccatcctgactacaagcaagacagtgtaataactgatgaaatcaactatagc
ctcatttggaagtgcaaccaaattgcagatgagctgtgtgaatgtccagagttacttgga
tcaggatttagaaaagcgaagtacagtggaggtaaaagcgacccttcagcctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (19)   
   RefSeq(nuc) (3)   
   GenBank (8)   
   EMBL (8)   
Protein domain (2)   
   Pfam (2)   
All databases (62)   

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