KEGG   Mus musculus (house mouse): 15481
Entry
15481             CDS       T01002                                 
Symbol
Hspa8, 2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73, Hspa10
Name
(RefSeq) heat shock protein 8
  KO
K03283  heat shock 70kDa protein 1/6/8
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu03040  Spliceosome
mmu04010  MAPK signaling pathway
mmu04141  Protein processing in endoplasmic reticulum
mmu04144  Endocytosis
mmu04213  Longevity regulating pathway - multiple species
mmu04612  Antigen processing and presentation
mmu04915  Estrogen signaling pathway
mmu05020  Prion disease
mmu05134  Legionellosis
mmu05145  Toxoplasmosis
mmu05162  Measles
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09120 Genetic Information Processing
  09121 Transcription
   03040 Spliceosome
    15481 (Hspa8)
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    15481 (Hspa8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    15481 (Hspa8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    15481 (Hspa8)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    15481 (Hspa8)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    15481 (Hspa8)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    15481 (Hspa8)
 09160 Human Diseases
  09172 Infectious disease: viral
   05162 Measles
    15481 (Hspa8)
  09171 Infectious disease: bacterial
   05134 Legionellosis
    15481 (Hspa8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    15481 (Hspa8)
  09164 Neurodegenerative disease
   05020 Prion disease
    15481 (Hspa8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    15481 (Hspa8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    15481 (Hspa8)
  09182 Protein families: genetic information processing
   03041 Spliceosome [BR:mmu03041]
    15481 (Hspa8)
   03009 Ribosome biogenesis [BR:mmu03009]
    15481 (Hspa8)
   03110 Chaperones and folding catalysts [BR:mmu03110]
    15481 (Hspa8)
   04131 Membrane trafficking [BR:mmu04131]
    15481 (Hspa8)
   03051 Proteasome [BR:mmu03051]
    15481 (Hspa8)
   03029 Mitochondrial biogenesis [BR:mmu03029]
    15481 (Hspa8)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    15481 (Hspa8)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-5
    PP5-interacting proteins
     15481 (Hspa8)
Spliceosome [BR:mmu03041]
 Complex B
  Other components
   Prp19 complex
    15481 (Hspa8)
 Complex C
   Prp19-CDC5 complex
    15481 (Hspa8)
Ribosome biogenesis [BR:mmu03009]
 Eukaryotic type
  Pre-60S particles
   Export and cytoplasmic maturation factors
    15481 (Hspa8)
Chaperones and folding catalysts [BR:mmu03110]
 Heat shock proteins
  HSP70 / DNAK
   15481 (Hspa8)
Membrane trafficking [BR:mmu04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Other core components
    15481 (Hspa8)
 Autophagy
  Chaperone mediated autophagy (CMA)
   Chaperones
    15481 (Hspa8)
Proteasome [BR:mmu03051]
 Eukaryotic proteasome
  Assembling factors
   Other assembling factors
    15481 (Hspa8)
Mitochondrial biogenesis [BR:mmu03029]
 Mitochondrial protein import machinery
  Endoplasmic reticulum membrane and cytosol
   Other ER-memrane and cytosol factors
    15481 (Hspa8)
Exosome [BR:mmu04147]
 Exosomal proteins
  Proteins found in most exosomes
   15481 (Hspa8)
SSDB
Motif
Pfam: HSP70 MreB_Mbl FGGY_C DDR Hydantoinase_A Radial_spoke_3
Other DBs
NCBI-GeneID: 15481
NCBI-ProteinID: NP_112442
MGI: 105384
Ensembl: ENSMUSG00000015656
UniProt: P63017
Structure
Position
9:40712572..40716498
AA seq 646 aa
MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTI
PTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDI
DANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKN
SLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQTAEKEEFEHQQKELE
KVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
NT seq 1941 nt   +upstreamnt  +downstreamnt
atgtctaagggacctgcagttggcattgatctcggcaccacctactcctgtgtgggtgtc
ttccagcatggaaaggtggaaattattgccaatgaccagggtaaccgcaccacgccaagc
tatgttgctttcacggacacagagagattaattggggatgcggccaagaatcaggttgca
atgaaccccaccaacacagtttttgatgccaaacgtctgatcgggcgtaggtttgatgat
gctgttgttcagtctgatatgaagcactggcccttcatggtggtgaatgatgcaggcagg
cccaaggtccaagtggaatacaaaggggagacaaaaagtttctacccagaggaagtgtcc
tccatggttctgacaaagatgaaggaaattgcagaagcgtacctcggaaagaccgttacc
aacgctgtggtcacagtgcccgcttacttcaatgactctcagcgacaggcaacaaaagat
gctggaactattgctggcctcaatgtacttcgaatcatcaatgaaccaactgctgctgct
attgcttacggcttagataagaaggtcggagctgaaaggaatgtgctcatttttgacttg
ggaggtggcacttttgatgtgtcaatcctcactattgaggatggaatttttgaggtcaaa
tcaacagctggagacacccacttaggtggagaagattttgacaaccgaatggtcaatcat
ttcattgctgagttcaagcgaaagcacaagaaagacatcagtgagaacaagagagctgtc
cgccgtctccgcacggcctgcgagcgggccaagcgcaccctctcctccagcacccaggcc
agtattgagattgattctctctatgagggaattgacttctatacctccattacccgggct
cgatttgaggagttgaatgctgacctgttccgtggcacactggaccctgtagagaaggcc
cttcgagatgccaagctggacaagtcacagatccatgatattgtcttggtgggtggttct
accagaatccccaagattcagaaacttctgcaagacttcttcaatggaaaagagctgaac
aagagcattaaccccgatgaagctgttgcctatggtgcagctgtccaggcagccattcta
tctggagacaagtctgagaacgttcaggatttgctgctcttggatgtcactcctctttcc
cttggtattgaaactgctggcggagtcatgactgtcctcatcaagcgcaataccaccatc
cccaccaagcagacacagactttcaccacctactctgacaaccagcctggtgtactcatt
caggtgtatgaaggtgaaagggccatgaccaaggacaacaacctgcttggaaagttcgag
ctcacaggcatccctccagcaccccgtggggtccctcagattgaggttacttttgacatc
gatgccaatggcatcctcaatgtttctgctgtagataagagcacaggaaaggagaacaag
atcaccatcaccaatgacaagggccgcttgagtaaggaagatattgagcgcatggtccaa
gaagctgagaagtacaaggctgaggatgagaagcagagagataaggtttcctccaagaac
tcactggagtcctatgccttcaacatgaaagcaactgtggaagatgagaaacttcaaggc
aagatcaatgatgaggacaaacagaagattcttgacaagtgcaatgaaatcatcagctgg
ctggataagaaccagactgcagagaaggaagaatttgagcatcagcagaaagaactggag
aaagtctgcaaccctatcattaccaagctgtaccagagtgcaggtggcatgcctggggga
atgcctggtggcttcccaggtggaggagctcccccatctggtggtgcttcttcaggcccc
accattgaagaggtggattaa

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Ontology (9)   
   KEGG BRITE (9)   
Pathway (12)   
   KEGG PATHWAY (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (116)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (104)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (542)   
   RefSeq(nuc) (2)   
   GenBank (270)   
   EMBL (270)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   Pfam (6)   
All databases (691)   

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