KEGG   Mus musculus (house mouse): 15483
Entry
15483             CDS       T01002                                 
Symbol
Hsd11b1
Name
(RefSeq) hydroxysteroid 11-beta dehydrogenase 1
  KO
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00140  Steroid hormone biosynthesis
mmu00980  Metabolism of xenobiotics by cytochrome P450
mmu01100  Metabolic pathways
mmu05204  Chemical carcinogenesis - DNA adducts
Module
mmu_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    15483 (Hsd11b1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    15483 (Hsd11b1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    15483 (Hsd11b1)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146  11beta-hydroxysteroid dehydrogenase
     15483 (Hsd11b1)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR DUF1776 THF_DHG_CYH_C Pyr_redox_2 2-Hacid_dh_C
Other DBs
NCBI-GeneID: 15483
NCBI-ProteinID: NP_001038216
MGI: 103562
Ensembl: ENSMUSG00000016194
UniProt: P50172 Q4JHD9
Structure
Position
1:complement(192903917..192946345)
AA seq 292 aa
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
NT seq 879 nt   +upstreamnt  +downstreamnt
atggcagttatgaaaaattacctcctcccgatcctggtgctcttcctggcctactactac
tattctacaaatgaagagttcagaccagaaatgctccagggaaagaaagtgattgtcact
ggggccagcaaagggattggaagagaaatggcatatcatctgtcaaaaatgggagcccat
gtggtattgactgccaggtcggaggaaggtctccagaaggtagtgtctcgctgccttgaa
ctcggagcagcctctgctcactacattgctggcactatggaagacatgacatttgcggag
caatttattgtcaaggcgggaaagctcatgggcggactggacatgcttattctaaaccac
atcactcagacctcgctgtctctcttccatgacgacatccactctgtgcgaagagtcatg
gaggtcaacttcctcagctacgtggtcatgagcacagccgccttgcccatgctgaagcag
agcaatggcagcattgccgtcatctcctccttggctgggaaaatgacccagcctatgatt
gctccctactctgcaagcaagtttgctctggatgggttcttttccaccattagaacagaa
ctctacataaccaaggtcaacgtgtccatcactctctgtgtccttggcctcatagacaca
gaaacagctatgaaggaaatctctgggataattaacgcccaagcttctcccaaggaggag
tgcgccctggagatcatcaaaggcacagctctacgcaaaagcgaggtgtactatgacaaa
tcgcctttgactccaatcctgcttgggaacccaggaaggaagatcatggaatttttttca
ttacgatattataataaggacatgtttgtaagtaactag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (13)   
   KEGG COMPOUND (13)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (34)   
   RefSeq(nuc) (8)   
   GenBank (13)   
   EMBL (13)   
3D Structure (7)   
   PDB (7)   
Protein domain (7)   
   Pfam (7)   
All databases (93)   

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