KEGG T01002: 15494

Mus musculus (house mouse): 15494

Entry

15494             CDS       T01002

Symbol

Hsd3b3, 9030618K22Rik

Name

(RefSeq) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

Organism

mmu Mus musculus (house mouse)

Pathway

mmu00140

Steroid hormone biosynthesis

mmu01100

Metabolic pathways

mmu04913

Ovarian steroidogenesis

mmu04925

Aldosterone synthesis and secretion

mmu04927

Cortisol synthesis and secretion

mmu04934

Cushing syndrome

Module

mmu_M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

mmu_M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

mmu_M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

mmu_M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:mmu00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    15494 (Hsd3b3)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    15494 (Hsd3b3)
   04925 Aldosterone synthesis and secretion
    15494 (Hsd3b3)
   04927 Cortisol synthesis and secretion
    15494 (Hsd3b3)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    15494 (Hsd3b3)
Enzymes [BR:mmu01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     15494 (Hsd3b3)
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     15494 (Hsd3b3)

SSDB

Motif

Pfam:

3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA KR RmlD_sub_bind Ldh_1_N Sacchrp_dh_NADP Ufm1

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

MGI:

Ensembl:

UniProt:

Position

3:complement(98648792..98672465)

AA seq 373 aa
MPGWSCLVTGAGGFLGQRIIQLLVQEKDLEEIRVLDKVFKPETREQFFNLGTSIKVTVLE
GDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAF
IFSSSVDVAGPNSYKDIVLNGHEDEHRESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTL
QTCALRPMCIYGERSQFLSNTIIKALKNKFILRGGGKFSTANPVYVGNVAWAHILAARGL
RNPKKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEWGFCLNSRWYLPVPILYWLAFLLET
VSFLLSPIYRYIPPFNRHLVTLTASTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTL
VEQHRETLDTKSQ

NT seq 1122 nt +upstreamnt +downstreamnt
atgcctgggtggagctgcctggtgactggagcaggagggtttttgggccagaggatcatc
cagttgttggtgcaggagaaagatcttgaggagatcagggtcctggacaaggtcttcaaa
cctgaaaccagggagcaattcttcaacctagggacaagcatcaaggtgacagtgttggaa
ggagacattcttgacacccagtacctgaggagagcttgccagggcatctctgttgtcatc
catactgctgccatcattgatgtcacaggtgtcattcccaggcagaccatcctagatgtc
aatctgaaaggtacccagaacttattggaggcctgtatccaagccagtgtgccagccttc
atcttctccagctcagttgacgttgcagggcccaactcttacaaggacattgtcctgaat
ggccacgaggacgagcatcgtgaaagcacatggtctgacccatacccatacagcaaaaag
atggctgagaaggcagtgctggcagccaatgggagcatgctgaaaaatggtggcactttg
caaacttgtgcattaaggcccatgtgcatttatggggagagaagtcaattcctttctaac
acaataattaaggccctcaaaaataagtttattctgagaggtgggggcaaattctccaca
gccaacccagtatatgtgggcaatgtggcctgggcacacattctggctgccaggggcctt
cgaaaccccaagaagtcaccaaatatccaaggagagttctactacatctcagatgatacc
cctcaccaaagttatgatgatttaaattacaccctgagcaaggagtggggcttctgcctc
aattccaggtggtaccttcctgtgcccatactgtactggcttgccttcctgctggaaact
gtgagcttcctgctgagtccaatctacagatatatacctccctttaaccgccacttggtc
acactgacagctagtacgttcactttctcctacaagaaagctcagcgagatctgggctat
gagccacttgtcagctgggaggaagccaagcagaaaacctcagagtggatcgggacacta
gtggagcagcacagggagacactggacacaaagtctcagtga

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