KEGG   Mus musculus (house mouse): 16974
Entry
16974             CDS       T01002                                 
Symbol
Lrp6, C030016K15Rik, Cd, Gw, ska26, ska<m26Jus>, skax26
Name
(RefSeq) low density lipoprotein receptor-related protein 6
  KO
K03068  low density lipoprotein receptor-related protein 5/6
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04150  mTOR signaling pathway
mmu04310  Wnt signaling pathway
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu05010  Alzheimer disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05200  Pathways in cancer
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    16974 (Lrp6)
   04150 mTOR signaling pathway
    16974 (Lrp6)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    16974 (Lrp6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    16974 (Lrp6)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    16974 (Lrp6)
   05226 Gastric cancer
    16974 (Lrp6)
   05224 Breast cancer
    16974 (Lrp6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    16974 (Lrp6)
   05022 Pathways of neurodegeneration - multiple diseases
    16974 (Lrp6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    16974 (Lrp6)
Membrane trafficking [BR:mmu04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    16974 (Lrp6)
SSDB
Motif
Pfam: Ldl_recept_b FXa_inhibition Ldl_recept_a DUF5050 SGL cEGF EGF
Other DBs
NCBI-GeneID: 16974
NCBI-ProteinID: NP_032540
MGI: 1298218
Ensembl: ENSMUSG00000030201
UniProt: O88572 A0A0R4J0A9
Position
6:complement(134423439..134543876)
AA seq 1613 aa
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF
GHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTE
IYWPNGLTLDYQERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWT
DWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS
PVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD
RVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL
LGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRIIGSNPCAEDNGGCS
HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG
VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY
WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG
SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSDMLGLNREVIADDLPHPFGLTQ
YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHC
SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP
IHSLRNVRAIDYDPLDKQLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLS
IDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERS
PKIERAALDGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESSDLSGANRIVLE
DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ
EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGD
IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
NCEVLCLIDQFRCANGQCVGKHKKCDHSVDCSDRSDELDCYPTEEPAPQATNTVGSVIGV
IVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHSPASVPLGYVPHPSSLSGSLPGMS
RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM
EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDV
NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
NT seq 4842 nt   +upstreamnt  +downstreamnt
atgggggccgtgctgaggagcctcctggcctgcagcttctgcgtgctgctgagagcggcc
cctttgttgctttatgcaaacagacgggacttgagattggttgatgctacaaatggcaaa
gagaatgcaacgattgtagttggaggcttggaggatgcagctgcggtggactttgtgttt
ggtcatggcttgatatactggagtgatgtcagcgaagaagccattaaacgaacagaattt
aacaaaactgaaagtgtacagaatgttgttgtttctggattattgtccccggatgggctg
gcatgtgattggcttggagaaaaattgtactggacagattctgaaactaatcgtattgaa
gtttctaatttagatggatctttacgaaaagttttattttggcaagagttggatcaaccc
agagctattgccttagatccatcaagtgggttcatgtactggacagactggggagaagtg
ccaaagatagaacgtgctgggatggatggctcaagtcgcttcgttataataaacacagag
atttactggccaaacggactgactctggactatcaggagcggaagctttactgggccgat
gcaaaacttaatttcatccataaatcaaacctggatggaacaaaccggcaggcagtggtt
aaaggttcccttccacatccttttgccttgacgttatttgaggacacattgtactggact
gactggaatacacactctattttggcttgcaacaaatatactggcgagggtctgcgtgaa
attcattctaacatcttctctcccatggatatacatgctttcagccaacagaggcagcca
aatgctacaaatccatgtggaattgataatggtggttgttcccatttgtgtttgatgtct
ccagtcaagcctttttatcagtgtgcttgcccaactggggtcaagctgctggagaatgga
aagacctgcaaagatggtgccactgaactattgctgttagcccgacggacagacttgagg
cgaatttctttggatacacccgattttactgacattgttctgcagttagaagatatccgg
catgccattgccatagactatgaccctgtagaaggctacatatactggacggatgacgaa
gtgagggctatccgtcgctccttcatagatggatctggcagtcagtttgtggtcacggcc
cagattgctcatcctgatggtattgctgttgactgggttgcaaggaacctgtactggaca
gacactggcacggatcgtatagaagtgacaaggctcaatgggaccatgaggaagatcttg
atttcagaggacttagaggagccccgggctatcgtgttagatcccatggttgggtacatg
tattggacagactggggagaaatcccaaaaatagagcgagctgctctggacggatctgac
cgagtagttcttgtcaacacttcccttggttggccaaacggcttagccctggattatgat
gaaggcacaatatactggggagatgccaaaacagacaaaattgaggttatgaataccgat
ggcaccgggaggcgagtgctggtggaagacaagatccctcacatatttgggtttaccttg
ctgggtgactatgtttactggactgactggcagaggcggagcatcgagagagtacacaaa
cggagcgcagagagggaggtcatcatagatcagctgccagacctcatgggactgaaggcc
acaagtgttcacagaatcattggttctaacccctgtgctgaggacaatggaggatgtagc
catctttgcctgtacaggcctcaggggcttcgatgcgcctgtcccattggctttgagctc
atcagtgacatgaagacatgcattgtccccgaggctttccttctgttctcgaggagagcg
gatatcagacgcatatctttggaaacaaacaacaacaatgtggccattcctctcactggt
gtcaaagaagcctctgctttggattttgatgtcacagacaacaggatttactggactgat
atatcactgaagactattagcagagcctttatgaatggcagtgcactggaacatgtggta
gagtttggcttagattatccagaaggcatggcagtggactggcttgggaagaacttatac
tgggcagacacaggaacaaatcgcattgaggtatcgaagttggacggacagcaccgacag
gttttggtatggaaagaccttgacagtcctcgagctctggcactggatcctgctgaaggg
tttatgtattggactgagtggggaggcaagcctaagattgacagggctgctatggatgga
agtgaacgcactacattagttccaaatgtaggccgagcaaatggtctcaccatcgactat
gctaaaaggcggctttactggacagacctggacactaacctaatagaatcctcagatatg
ctcggactcaaccgtgaagttatagcagatgacttgcctcatccttttggcttaactcag
taccaagattacatctactggacagactggagccgacgcagcattgaacgtgccaacaaa
accagtggccaaaaccgcaccatcatccagggccatttggactatgtgatggacatcctg
gtcttccactcttcccggcaggcagggtggaatgagtgtgcctccagcaacgggcactgc
tcccacctctgcttggctgtgcccgtcggaggttttgtgtgtggatgccctgcccactac
tccctgaatgctgacaacaggacctgcagtgctcccaccaccttcctgctcttcagtcag
aagagcgccatcaaccgcatggtgattgatgaacaacagagccctgacatcatccttcct
atccacagccttcggaacgtccgggccattgactatgaccctttggacaagcagctctac
tggattgactctcgacaaaactccatacgaaaggcacatgaagatggtggccagggtttt
aatgtagttgcaaactcagtcgcaaatcagaaccttgaaatacagccctatgatctcagc
attgatatttatagccgttacatctactggacctgtgaagctaccaatgtcattgatgtg
acgagattagatggacgatcagttggagtggttctaaaaggcgagcaagacagacctcga
gccattgtggtaaaccccgagaaagggtatatgtattttaccaatcttcaggaaagatct
cctaaaattgaacgggctgcattggatggtacagaacgagaggtcctctttttcagtggc
ttaagtaaaccaattgctttggctcttgatagcaagctgggcaagctcttctgggctgac
tcagatctccggcgaattgaaagcagtgatctctcaggtgccaacaggatcgtgctagaa
gactctaatatattacagcctgtgggcctgaccgtgtttgaaaactggctctattggatt
gataaacagcagcagatgattgaaaaaattgacatgactggtcgagaaggaagaaccaag
gtccaggctcgaattgctcagctgagtgacatccatgcagtaaaggagctgaaccttcag
gagtacagacagcacccttgtgcccaggataatggtggctgttcacatatctgccttgta
aaaggagatggtacgacaagatgctcctgccccatgcacttagttctgcttcaggatgag
ctgtcctgtggagagcctccaacgtgttctcctcagcagtttacctgcttcactggggac
attgactgcatccctgtggcttggcggtgtgatgggttcactgagtgcgaagaccacagc
gatgaactcaattgtcccgtgtgctcagagtctcagttccagtgtgccagcgggcagtgc
attgatggtgcccttcgatgcaatggcgatgcgaactgccaggacaaatcagatgagaag
aactgtgaagtgctttgtttaattgatcagttccgctgtgccaatggtcagtgcgttgga
aagcacaagaaatgtgaccacagtgtggactgcagtgacagatctgacgagctggactgt
tatccaactgaggagccagcaccacaagccaccaacacagttggttctgttattggagta
attgtcaccatttttgtgtctggaaccatatactttatctgccagaggatgctgtgtcct
cgtatgaagggagacggggagaccatgactaacgactatgtggttcacagcccggcgtct
gtgccccttggttatgttcctcacccaagctctctctctggatctcttccaggaatgtct
cgaggcaaatcaatgatcagttccctcagtatcatggggggaagcagtgggcccccctat
gatcgagcgcacgtcacgggagcctcctcaagcagttcttccagtaccaaaggcacttac
ttccctgcaattttgaacccaccaccatcgcctgccacagaaagatcccattataccatg
gaatttggttattcttccaacagtccttccacacataggtcctacagctataggccgtac
agctaccggcactttgcaccgcccaccacaccctgcagcactgatgtctgtgacagtgac
tatgctcctagccggaggatgacctcggtggcaacagccaagggctacaccagtgacgtg
aactatgactcagaacctgtgcccccaccgcccacaccccgaagccagtacttgtcagcg
gaggagaactatgaaagctgccccccttccccatacacggagaggagttactcccaccac
ctctacccgccaccaccctccccctgcacggactcctcctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (16)   
   RefSeq(nuc) (2)   
   GenBank (7)   
   EMBL (7)   
Protein domain (7)   
   Pfam (7)   
All databases (59)   

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